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2009 NOV 29 ... deficits of insomnia. A molecular mechanism by which brief sleep deprivation alters hippocampal function is now identified in mice, involving the impairment of cyclic-AMP- and ... impact of sleep deprivation. Further, our work identifies specific molecular changes in neurons caused by sleep deprivation, and future work on this target protein promises to reveal ...
2009 NOV 23 ... in the induction of protein synthesis-dependent late-LTP in the CA1 region in hippocampal slices in vitro. We found that the inhibition of actin polymerization affects protein ... Network and Its Effect on Long-Term Potentiation and Synaptic Tagging in Hippocampal CA1 Neurons in Slices In Vitro. Journal of Neuroscience, 2009;29(39):12167-12173). For ...
2009 NOV 24 ... finch is a thin superficial part of the caudal pallium adjoining the medially situated hippocampal formation, whereas the CI is demarcated between the CDL and the parahippocampal area of ... the CI is demarcated between the CDL and the parahippocampal area of telencephalon. Neurons of the corticoid complex are classified into three main cell groups: predominant ...
2009 NOV 25 ... specifically in the DG. Unlike in wild-type (WT) littermates, spatial firing of hippocampal neurons was completely dissociated from a distinct visual cue and instead, tended to stay ...
2009 NOV 23 ... of granule cell lamination, called granule cell dispersion, in the dentate gyrus of the hippocampal formation. Moreover, antibody blockade of Reelin in normal, adult mice resulted in ... the marginal zone of the cortex. It plays an important role in the migration of cortical neurons and the development of cortical lamination," researchers in Freiburg, Germany report. ...
2009 NOV 23 ... Scientists discuss in 'IGF-1 and pAKT signaling promote hippocampal CA1 neuronal survival following injury to dentate granule cells' new findings in ... cells' new findings in apoptosis. "Insulin-like growth factor-1 (IGF-1) protects neurons from apoptosis and in vivo offers neuroprotective support to hippocampal CA1 pyramidal ...
2009 NOV 23 ... arrest victims may experience transient brain hypoperfusion leading to delayed death of hippocampal CA1 neurons and cognitive impairment. We prevented this in adult rats by inhibiting the ...
2009 NOV 23 ... In contrast, we found no evidence for presynaptic expression in cultured GAD67-positive hippocampal interneurons and in CA1 basket cell terminals," wrote D. Vullhorst and colleagues, ... We detected ErbB4 immunoreactivity in GABAergic interneurons but not in pyramidal neurons, a finding that was further corroborated by the lack of ErbB4 mRNA in ...
2009 NOV 24 ... in brain cholinesterase activity and neuronal death measured histologically in the hippocampal region. Oleanolic acid isolated from A. cordata also inhibited neuronal death, elevation ... neurotoxicity induced by amyloid beta (A beta) protein (25-35) in cultured rat cortical neurons and antidementia activity in mice. Exposure of cultured cortical neurons to 10 mc M A ...
2009 NOV 23 ... a gel-based proteome profiling of the long-term (12 h) effects of BDNF in cultured hippocampal neurons. BDNF changed the abundance of proteins involved in (i) Nucleobase, nucleoside, ...
2009 NOV 23 ... glycosyl phosphatidyl inositol-anchored cyan fluorescent protein construct. Also in hippocampal primary neurons, which showed a differential distribution of SPCA1 expression in Golgi ...
2009 NOV 23 ... survival. However, the mechanisms responsible for the effects of zinc deficiency on hippocampal neurogenesis and neuronal death remain obscure," scientists writing in the journal ... a reduction in proliferating cells labeled with bromo-deoxyuridine (BrdU) and immature neurons labeled with doublecortin (DCX) immunoreactivity in the dentate gyrus of the ...
2009 NOV 27 ... treatment significantly increased apoptosis (activated caspase-3 expression) in hippocampal CA3 and CA1, and cerebellar molecular and granular layers, an effect abolished by ... of alfaxalone and finasteride. Double-label immunohistochemistry showed that both neurons and astrocytes were caspase-3 positive. Finasteride treatment also increased the number ...
2009 NOV 26 ... mg/kg quercetin for 15 days before ischemic surgery protected pyramidal neurons of the hippocampal CA1 region from ischemic damage. In the OE-treated ischemic group, gliosis (activation ...
2009 NOV 23 ... the Abeta-degrading enzyme, neprilysin, stimulates the isoform-specific degeneration of hippocampal CA1 neurons and septal neurons in apoE4 transgenic mice and that this effect is ...
2009 NOV 27 ... root ganglion neurons, the molecular and Purkinje cell layer of adult cerebellum, and hippocampal fimbria. Overexpression of a nonphosphorylated mutant (Tyr(32) to Phe(32)) of CRMP2 in ...
2009 NOV 29 ... does not necessary deny the important role of neurogenesis in memory acquisition." Hippocampal neurogenesis could have a dual role, he says, in both erasing old memories and acquiring ... Short-term memory may depend in a surprising way on the ability of newly formed neurons to erase older connections. That's the conclusion of a report in the November 13th ...
