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2009 MAY 5 ... aimed to investigate the role of the extracellular pH on the transport activity of nine human and four rat OATPs/Oatps. Furthermore, we aimed to test the concept that OATP/Oatp ... CA, Meier PJ, Stieger B. Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters. Am J Physiol Cell Physiol 296: C570-C582, 2009," ... 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid-sensitive chloride/bicarbonate exchanger in CHO-K1 cells and that OATP/Oatp-mediated substrate transport is paralleled by ...
2009 OCT 19 ... Clinical Oncology (Expression of anionexchanger 1 is associated with tumor progress in human gastric cancer. Journal of Cancer Research and Clinical Oncology, ...
2009 APR 13 ... functional heterogeneity of the mouse intrahepatic biliary epithelium.' "Rat and human biliary epithelium is morphologically and functionally heterogeneous. As no information ... cystic fibrosis transmembrane conductance regulator (CFTR), and chloride bicarbonate anionexchanger 2 (Cl(-)/HCO(3)(-) AE2) by immunofluorescence and western blot; and ...
2009 AUG 4 ... Here, we immunolocalize the Nhe1 protein to the luminal membrane domain in mouse and human CPE. The Na+-dependent pHi recovery of Nhe1 wild-type (Nhe1-wt) mice in the absence of ... Na+-dependent pH(i) increases and probably for CSF secretion. In the current study, the anion transport inhibitor DIDS had no effect on the residual pHi recovery in acidified CPE ... Denmark, "Damkier HH, Prasad V, Hubner CA, Praetorius J. Nhe1 is a luminal Na+/H+ exchanger in mouse choroid plexus and is targeted to the basolateral membrane in Ncbe/Nbcn2-null ...
2009 JAN 26 ... date, however, almost no information is available with respect to its effect on the human intestinal apical anionexchanger Cl-/OH- (HCO3-). The present studies were, therefore, ...
2009 SEP 14 ... lacking the PDZ interaction motif (DRA-ETKFminus) were expressed constitutively in human embryonic kidney (HEK) and inducibly in Caco-2/BBE cells. DRA-mediated Cl/HCO3 exchange ... 8 - 16-fold and was delivered to the apical surface of polarized Caco-2 cells. Putative anion transporter 1 and cystic fibrosis transmembrane regulator did not contribute to Cl/HCO3 ... According to recent research from Tubingen, Germany, "The Na/H exchanger 3 (NHE3) and the Cl/HCO3 exchanger down-regulated in adenoma (DRA) together facilitate ...
2009 OCT 5 ... 3 (erythrocyte membrane protein hand 3)] is a major membrane glycoprotein expressed in human erythrocytes where it mediates the exchange of chloride and bicarbonate across the ... According to a study from Toronto, Canada, "AE1 [anionexchanger 1, also known as SLC4A1 (solute carrier family 4, anionexchanger, member 1) ...
2009 JUL 27 ... (GPA) and anionexchanger 1 (AE1). We found that during the terminal differentiation of human CD34(+) erythroid progenitor cells in culture, key components of the endoplasmic ...
2009 JUL 7 ... hypothesis that nitrite transport by RBCs is regulated by fractional saturation. Using human RBCs, nitrite consumption was faster at lower fractional saturations, consistent with ... to mediate nitric oxide (NO) formation during hypoxia. Nitrite is predominantly an anion at physiological pH, raising questions about the mechanism by which it enters the red ... increases nitrite import or decreases the rate of nitrite export. A role for anion exchanger (AE)-1 in the control of nitrite export was suggested by increased intracellular nitrite ...
2009 NOV 30 ... role of the Na+-H+ exchanger isoform 1 (NHE1) in leptin-induced oxidative stress in human monocytes.' "Leptin, a 16-kDa cytokine produced mainly by the adipose tissue, is known ... of the Na+-H+ exchanger isoform 1 (NHE1) also inhibited leptin-induced superoxide anion production but at the same time amplified leptin-induced production of other oxidative ...
2009 JAN 26 ... Cl(-)," wrote P. Hafner and colleagues, University of Zurich, Center for Integrative Human Physiology.
The researchers concluded: "However, metabolic acidosis ... have been published. According to a study from Zurich, Switzerland, "The Cl(-)/anionexchanger pendrin (SLC26A4) is expressed on the apical side of renal non-type A ...
2009 JUN 15 ... results, 'Reduction of anionexchanger 2 expression induces apoptosis of human hepatocellular carcinoma cells,' are detailed in a study published in Molecular and ...
2008 DEC 15 ... (Characterization of the 5'-flanking region and regulation of expression of human anion exchanger SLC26A6. Journal of Cellular Biochemistry, 2008;105(2):454-466).
For ...
2008 AUG 11 ... the effects of Lactobacillus on luminal chloride/hydroxyl (Cl-/OH-) exchange activity in human intestinal epithelial cells. Postconfluent Caco-2 cells were treated with the ... Cl-/OH- exchange activity, LA treatment increased the surface expression of the apical anionexchanger, SLC26A3 [Down Regulated in Adenoma (DRA)]. The increased DRA membrane ...
2008 SEP 22 ... new findings in hormones. According to recent research from the United States, "Because human duodenal mucosal bicarbonate secretion (DMBS) protects duodenum against acid-peptic ... E2 dose dependently stimulated murine DMBS, which was attenuated by a Cl(-)/HCO3(-) anionexchanger inhibitor 4,4'-didsothio-cyanostilbene-2, 2'-disulfonic acid, removal of ...
2008 SEP 15 ... ion pair, mutant Ae1 E699Q transports sulfate without cotransport of protons, similar to human erythrocyte AE1 in which the corresponding E681 carboxylate has been chemically ... valuable paths toward understanding substrate selectivity and self-inhibition in SLC4 anion transporters."
Chernova and colleagues published their study in American ... - Cell Physiology. "The SLC4A1/AE1 gene encodes the electroneutral Cl(-)/HCO(3)(-) exchanger of erythrocytes and renal type A intercalated cells. AE1 mutations cause familial ...
2008 DEC 15 ... in the identification of meat species in feedstuffs and in multiplex SNP typing of the human IL-10 gene promoter region are demonstrated, clearly suggesting the potential for much ... with a new pyrrolidinyl peptide nucleic acid (PNA) probe and treated with a strong anionexchanger," scientists in Bangkok, Thailand report.
"The complementary ...
2008 DEC 8 ... Isc. The phenomenon of enhanced ion fluxes upon acid stimulation was confirmed in human esophageal specimens. Our results demonstrated that the mechanism of acid-induced rapid ... ion fluxes is dependent on the presence of bicarbonate ions as well as functional anion transporters and Na+/H+ exchanger, but independent of cystic fibrosis transmembrane ...
2008 DEC 16 ... Williamson and colleagues published their study in the Journal of Cell Science (Human kidney anionexchanger 1 localisation in MDCK cells is controlled by the phosphorylation ...
