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2009 MAY 5 ... of antidotes available that have been approved by the FDA for use in the United States. Hydroxocobalamin, or Cyanokit, can be used for confirmed or suspected cyanide poisonings. The cyanide ...
2009 NOV 9 ... KGaA, Darmstadt, Germany, the exclusive rights to market and sell CYANOKIT® 5 g (hydroxocobalamin for injection) ANTIDOTE in the U.S. CYANOKIT® is indicated for the treatment of ...
2009 JUL 20 ... with L-NAME 100 mc M [pD(2) = 5.8 +/- 0.04], L-NAME 300 mc M [pD(2) = 5.9 +/- 0.06], Hydroxocobalamin 30 mc M [pD(2) = 5.8 +/- 0.06] or ODQ 10 mc M [pD(2) = 5.8 +/- 0.04]. In addition, in ...
2009 AUG 11 ... (ACh)-mediated relaxation. Scavenging the uncharged form of NO (NO center dot) with hydroxocobalamin (HXC) or HNO with l-cysteine, or 4-AP decreased the sensitivity to ACh, and a ...
2009 JUL 27 ... effects on -L[C-14]arginine-to-L-[C-14]citrulline conversion by NOS1, NOS2, and NOS3. Hydroxocobalamin (OH-Cbl), cobinamide, and dicyanocobinamide (CN2-Cbi) potently inhibited all isoforms, ...
2008 FEB 11 ... 'Prevention of hydrogen sulfide (H2S)-induced mouse lethality and cytotoxicity by hydroxocobalamin (vitamin B(12a)),' are detailed in a study published in Toxicology. According to a ...
2008 JUN 9 ... Florida Department of Health, Office of Emergency Operations, will stock Cyanokit(R) 5g (hydroxocobalamin for injection) ANTIDOTE for Cyanide Poisoning in the State's emergency medical service ...
2008 DEC 24 ... We analyzed data from 423 subjects who did not use any form of cyanocobalamin, hydroxocobalamin, or folic acid supplementation, neither at baseline nor during follow-up. Folate ...
2008 SEP 15 ... protocols. (3) Long-term treatment: In cobalamin-responsive patients, most centres use hydroxocobalamin (1-14 mg/week i.m. or 5-20 mg/week orally), while two centres use cyanocobalamin. All ...
2008 MAY 26 ... manifestations, displaying non-inducible propionate incorporation in the presence of hydroxocobalamin (OHCbl) in vitro and high plasma odd-numbered long-chain fatty acid (OLCFA) ...
2008 MAR 18 ... Using this paradigm, the current cyanide antidotes, viz., nitrite plus thiosultate and hydroxocobalamin, as well as some potential cyanide antidotes that we developed, were evaluated pre- and ...
2008 MAY 27 ... and colleagues.
The researchers concluded: "Generally they behaved as hydroxocobalamin, but with greater accumulation in the liver, possibly reflecting the cyanide-detoxifying ...
2008 JUN 9 ... to a study from the United States, "To review the recently approved cyanide antidote, hydroxocobalamin, and describe its role in therapy. Relevant publications were identified through a ...
2008 APR 7 ... "The Co-containing compounds studied include cyanocobalamin (CN-Cbl, vitamin B12), hydroxocobalamin (OH-Cbl), and Co(II). The species studied were well separated using a 70 cm length x 75 ...
