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2009 NOV 16 ... and non-phosphospecific solutions. Shown b! elow are western blots of hydroxyurea-treated Cos-7 cells expressing an increasing amount of phosphorylated serine p53's. ...
2009 SEP 14 ... in estrogen receptor (ER)-positive breast cancer cells, UV or ionizing radiation and hydroxyurea rapidly activate ATR-dependent phosphorylation of endogenous p53 and Chk1. ...
2009 SEP 28 ... basis, it was 10 times more potent at causing death of colon cancer cells than hydroxyurea, a chemotherapeutic drug commonly used in cancer treatment. Beyond that, ...
2009 NOV 1 ... to recent research from Bombay, India, "The clinical and hematological response to hydroxyurea was evaluated in beta thalassemia patients in western India with variable clinical ...
2009 NOV 9 ... repair (PRR) pathways in the suppression of GCRs, checkpoint function, sensitivity to hydroxyurea (HU) and methyl methanesulfonate (MMS), and ubiquitination of proliferating cell nuclear ...
2009 NOV 1 ... mutant did not show any defect in DNA replication checkpoint activation in response to hydroxyurea treatment. The phenotype of the mcm6 mutant was suppressed when the mutant protein was ...
2009 OCT 5 ... and haemoglobin synthesis in K562 cells treated with low concentrations of doxorubicin, hydroxyurea, cytosine arabinoside, cisplatin and haemin. Caspase-3 activation, mitochondrial ...
2009 SEP 21 ... red cell during intravascular hemolysis of cell-free plasma hemoglobin and arginase [4]. Hydroxyurea is the only drug approved by the Food and Drug Administrations specifically for SCD. It ...
2009 NOV 1 ... and 6 protein complex (Smc5/6)." "Rad60 is phosphorylated in response to hydroxyurea (HU)-induced DNA replication arrest in a Cds1(Chk2)-dependent manner. Rad60 localizes in ...
2009 AUG 31 ... multi-log cytotoxicity in a unique pattern of delayed cytotoxicity in S-phase. As hydroxyurea, a ribonucleotide reductase inhibitor that activates mismatch repair, can increase ...
2009 SEP 28 ... of human superoxide dismutase 1 expression in a mouse model on the embryotoxicity of hydroxyurea.' According to recent research from Canada, "Oxidative stress is hypothesized to ...
2009 OCT 6 ... in S-phase cells over younger seedlings) in response to the replication-blocking agent hydroxyurea (HU) and to the DNA double-strand break inducer bleomycin (BLM). Here we show that ...
2009 SEP 8 ... Rec8 sites. We also showed that such a change in a distribution of Spo11 is affected by hydroxyurea treatment. Interestingly, deletion of REC8 influences the localization of Spo11 to ...
2009 SEP 28 ... UV-radioresistant DNA synthesis and caused premature recovery of replication after hydroxyurea arrest, indicating that lack of AND-1 compromises checkpoint activation. This may be ...
2009 SEP 28 ... rapamycin insensitive. Cells lacking Tor1 are highly sensitive to the DNA-damaging drugs hydroxyurea (HU) and methyl methanesulfonate, similar to mutants of the checkpoint kinase Rad3 ...
2009 OCT 5 ... treated with various drugs [celecoxib, prostaglandin E-2 (PGE(2)), PD98059, U0126, and hydroxyurea] and were then analyzed using reverse transcription-PCR, confocal microscopy, Western ...
2009 NOV 9 ... were recently awarded a $23 million federal grant to launch a national study of the drug hydroxyurea to prevent first strokes in children and adolescents with sickle cell anemia (SCA). ...
