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2009 JUN 15 ... (80-90%) and specificity (90%) for the diagnosis of CJD. Low or undetectable CSF hypocretin-1 (orexin-1) levels constitute a diagnostic biomarker for narcolepsy with cataplexy. ...
2009 SEP 15 ... case-control. Sleep centers of general hospitals. 200 patients with narcolepsy/hypocretin deficiency, with a primary focus on recent onset cases and 200 age-matched healthy ...
2009 JUL 28 ... (ref. 4)." "Following studies in dogs(5) and mice(6), a 95% loss of hypocretin-producing cells in postmortem hypothalami from narcoleptic individuals was ...
2009 SEP 14 ... favor the occurrence of cataplexy and cataplexy-like symptoms, including orgasmolepsy. Hypocretin deficiency and reward dysregulation in narcolepsy may further facilitate this phenomenon ...
2009 SEP 28 ... According to a study from Tokyo, Japan, "The cause of hypocretin cell loss in human narcolepsy-cataplexy is unknown but has been suggested to be ...
2009 JUN 15 ... Zurich. H-1-MRS was performed in fourteen narcolepsy patients with cataplexy, CSF hypocretin deficiency (10/10) and HLA-DQB1*0602 positivity (14/14) and 14 age, gender and body mass ...
2009 JUN 16 ... systems such as the pontine and medullary noradrenergic neurons and the hypothalamic hypocretin neurons," wrote P. Fort and colleagues, .
The researchers concluded: ...
2009 SEP 28 ... According to recent research from the United States, "The neuropeptide orexin (hypocretin) increases energy expenditure partially through increasing spontaneous physical ...
2009 AUG 25 ... with those of previous studies. The gold standard exam of narcolepsy with cataplexy is Hypocretin-1 dosage, but in patients without cataplexy and idiopathic hypersomnia, there are no ...
2009 JUN 29 ... In hypothalamus, DHEA and DHT significantly up-regulated the gene expression of hypocretin (Hcrt; also called orexin), pro-melanin-concentrating hormone (Pmch), and protein kinase ...
2009 JUL 20 ... disrupts intrinsic excitability but does not abolish glucose or pH responses of orexin/hypocretin neurons,' is newly published data in European Journal of Neuroscience. According to ...
2009 JUN 1 ... to cocaine conditioned stimuli and on cocaine-induced alterations in central opioid, hypocretin/orexin, and D2 receptor systems, mate Sprague-Dawley rats received intravenous infusions ...
2009 JUN 15 ... actions at nanomolar levels on the NPY neurons, stronger than the actions of ghrelin and hypocretin/orexin. Bombesin-related peptides reduced input resistance and depolarized the membrane ...
2009 SEP 15 ... Sleep, "Narcolepsy with cataplexy is characterized by a loss of approximately 90% of hypocretin (Hcrt) neurons. However, more than a quarter of narcoleptics do not have cataplexy and ...
2009 SEP 21 ... responding to ethanol. This effect was selectively blocked by pre-treatment with the hypocretin-1/orexin-A antagonist SB-334867 (10 mg/kg, i.p.). At the dose tested, SB-334867 did not ...
2009 JUL 27 ... According to recent research from Lublin, Poland, "The effects of seizures on the hypocretin/orexin system have not yet been investigated in epileptic patients. The present study ...
