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2009 NOV 2 ... when administered at 24 hours after doses of total-body irradiation that produce the lethal GI syndrome. There are no published studies of agents that accomplish this enhanced stem ...
2009 SEP 21 ... efficacy data when "evidence is needed to demonstrate efficacy of new drugs against lethal or permanently disabling toxic substances when efficacy studies in humans, ethically ... shown that doses in the range of 5 to 30 mg/kg AEOL 10150 given daily up to 24 hrs after irradiation and administered for as long as 10 weeks mitigate functional lung injury in rats and led ...
2009 NOV 2 ... "The DNA double-strand break (DSB) is the primary lethal lesion after therapeutic radiation. Thus, the development of assays to detect and to ... "Phosphorylation of histone H2AX to form gamma-H2AX is a known marker for irradiation-induced DNA DSBs. However, the first generation assay involves the use of ...
2009 AUG 24 ... showed higher relative biological effectiveness (RBE) values were associated with lower lethal dose (LD) values, while lower RBE was associated with higher LD values. Exposure to ... [WST-1] assays, respectively. Irradiation caused GCC and neurite destruction on a time-and irradiation dose-dependent manner. ...
2009 JUN 22 ... We show that host NKT cells can induce an in vivo expansion of donor Tregs that prevents lethal GVHD in mice after conditioning with fractionated lymphoid irradiation (TLI) and ...
2009 SEP 28 ... order to monitor membrane damage. Radiation-induced mortality of the animals following a lethal dose of gamma-radiation was also examined. Key findings Centella asiatica extract ... effects of ionizing radiation exposure. Protection of DNA under in-vitro conditions of irradiation Was estimated using plasmid relaxation assay," scientists in Trichur, India report. ...
2009 AUG 11 ... was injected subcutaneously (SC) at different doses into male CD2F1 mice [LD(50/30) (lethal radiation dose that results in the mortality of 50% mice in 30 days) radiation dose of ... Time optimisation was done by SC administration of GT3 at different intervals before irradiation. Dose reduction factor (DRF) was determined by probit analysis using mortality as the ...
2009 MAY 12 ... a human cell line. Although the Sf9 and human cell lines were equally susceptible to the lethal effects of N-nitroso alkylating agents, the components of DNA damage-induced and the ... more resistant to growth inhibition and apoptosis induction effects of x-ray irradiation than several human cell lines of different origins. The single-cell electrophoresis ...
2009 MAY 12 ... (Ino) administered to mice after irradiation with X-rays. Survival of mice exposed to lethal and sublethal doses of X-rays was studied."
"Peripheral blood cells ...
2009 NOV 30 ... In contrast, a chemical inhibitor of CHK1, Chir124, sensitized cancer cells to the lethal effect of AZD1152," wrote Y.G. Tao and colleagues. The researchers ... Cycle (The aurora B kinase inhibitor AZD1152 sensitizes cancer cells to fractionated irradiation and induces mitotic catastrophe. Cell Cycle, 2009;8(19):3172-3181). For ...
2009 APR 13 ... "Our previous in vitro study has shown that toluidine blue (TB)-mediated lethal photosensitization of periodontal pathogens (PPs) from periodontal patients is possible. ... the experimental photodynamic therapy (PDT) group was treated with 1 mg/ml TB and light irradiation (60 J/cm(2), 635 nm, 337 s). Those in control groups were subjected to 140 J/cm(2) laser ...
2009 NOV 9 ... to accidental or deliberate radiation poses a threat to public health, proving lethal at higher doses in large part because of deleterious effects on marrow. In those cases, ... who could serve as HCT donors. Here, we assessed in a canine HCT model the total body irradiation (TBI) doses after which transplants might be required and successful engraftment would ...
2009 MAY 27 ... According to recent research from Madrid, Spain, "Non-lethal stress treatments (X-radiation or heat shock) administered to Drosophila imaginal discs ... compensatory proliferation. We have tested this hypothesis by analysing the response to irradiation-induced apoptosis of disc compartments that are mutant for dpp, for wg, or for both. We ...
2009 OCT 19 ... single doses of 250 kVp x-rays and on repair of damage (sublethal and potentially lethal damage repair; SLDR, PLDR) in both exponential and plateau phase cells. Cells were ... phase cells. Cells were exposed to 2 mc M tetrac (1 h at 37 degrees C) prior to x-irradiation." "At varying times after irradiation, cells were re-plated in medium ...
2009 SEP 28 ... product, Rx100, a potent radioprotectant as well as radiomitigator, protects against lethal, whole-body radiation when administered before, during, or up to 72 hours after ... with a single subcutaneous dose at either 48 or 72 hours after lethal, whole-body gamma irradiation. Results at both time points were essentially identical and only slightly lower than ...
2009 MAY 11 ... injected with 20 or 50 mu Ci At-211, but none with the same quantities of Bi-213, had lethal myeloablation. Severe reversible acute hepatic toxicity occurred with 50 mu Ci Bi-213, ... using a bismuth-213 (Bi-213)-labeled anti-CD45 antibody to replace total body irradiation as conditioning for hematopoietic cell transplantation in a canine model. Although this ...
2009 MAY 19 ... 10-17 with a neoR gene. ASPP2(-/-) mice were not viable because of an early embryonic lethal event. Although ASPP2(+/-) mice appeared developmentally normal, they displayed an ... derived from ASPP2(+/-) mice exhibited an attenuated apoptotic response to gamma-irradiation compared with ASPP2(+/+) thymocytes. Additionally, ASPP2(+/-) primary mouse embryonic ...
2009 OCT 19 ... "Here we describe a profound disruption of the marrow microenvironment after lethal total body irradiation of mice that leads to the generation of osteoblasts restoring the ...
2009 APR 13 ... from the curing model of cGVHD, anti-CD137 given simultaneously with BMT resulted in lethal GVHD. Histopathologic evaluation revealed inflammation and damage of target organs from ... of cGVHD after bone marrow transplantation (BMT) in mice conditioned with total body irradiation (TBI). We used the B10.D2 -> Balb/c (H-2(d)) minor histocompatibility ...
2009 APR 14 ... of the sequential application of heat and ionizing radiation results from the additional lethal damage arising from the interaction of sublesions induced by both agents. These ... on both the sequence of application (i.e. whether heat is applied prior to or following irradiation) and the temperature," scientists writing in the International Journal of ...
