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2009 NOV 16 ... gene are sensitive to interferon, as they fail to direct degradation of promyelocytic leukemia protein (PML), a component of host nuclear domain 10s." "While ... Simplex Virus, Herpes Virus, Herpesvirus, Interferon, Oncology, Promyelocytic Leukemia, Therapy, Treatment, Varicella-Zoster Virus, Virology, Columbia University. This ...
2009 NOV 23 ... Biotechnology, Cancer Gene Therapy, Genetics, Genomics, Hematology, Immunotherapy, Leukemia Gene Therapy, Measles, Oncology, Treatment, Virology, University of Lyon. This article ...
2009 NOV 23 ... for use by the U.S. Food and Drug Administration in patients with chronic myeloid leukemia, significantly inhibited the growth and invasiveness of ovarian cancer cells and also ... that women with this type of ovarian cancer could benefit." Recent gene expression studies have shown that about one-third of women have ovarian cancers with ... chemotherapy - both made the other work better - it may be possible to add the targeted therapy as a first line treatment if its efficacy is confirmed in future studies, adding a new ...
2009 NOV 23 ... a self-protein and clinically relevant tumor antigen associated with most types of adult leukemia: Wilms tumor gene 1 (WT1)," scientists writing in the Journal of Immunotherapy report. ... PA 19106-3621, USA. Keywords: Country:France, Cancer Vaccines, Anticancer Therapy, Antitumor Activity, Biotechnology, Escherichia coli, Hematology, Immunization, ...
2009 NOV 23 ... "The gene(s) responsible for natural killer (NK)-cell lymphoma/leukemia have not been identified. In the present study, we found that in NK-cell lymphoma lines ... Keywords: City:Hondo, Country:Japan, Antisense Technology, Biotechnology, Gene Therapy, Genetics, Genomics, Hematology, Leukemia, Lymphoma, Oncology, Treatment, Tumor ...
2009 NOV 16 ... BCR-ABL inhibitor imatinib revolutionized the treatment of patients with chronic myeloid leukemia (CMIL). However, resistance to imatinib has become a clinically significant issue, ... have been associated with imatinib resistance, including mutations to the BCR-ABL gene, increased production of BCR-ABL, and activation of BCR-ABL-independent pathways (e.g., ... Hematology, Imatinib, Myeloid Leukemia, Oncology, Protein Kinase Inhibitor, Sprycel, Therapy, Treatment, Washington University. This article was prepared by Biotech ...
2009 NOV 16 ... "Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia ( ATL) but the expression of HTLV-1 ... a GFP-Tax fusion protein, Gax, under the control of the HTLV-1 enhancer (EL4-Gax). Gax gene transcription was silenced in vivo but quickly up-regulated in ex vivo culture. Analysis ... London WC1X 8HL, England. Keywords: Japan, Osaka, Biotechnology, DNA, Gene Therapy, Genetics, Genomics, HTLV, Hematology, Human T-Lymphotropic Virus, Lymphoma, Oncology, ...
2009 NOV 23 ... in Brazilian patients with classical Hodgkin lymphoma,' is newly published data in Leukemia & Lymphoma. "The human germinal center-associated lymphoma (HGAL) gene has prognostic ... Lymphoma, Leukemia, Oncology, Pharmaceuticals, Protein Expression, Proteins, Proteomics, Therapy, Treatment, Vinblastine. This article was prepared by Biotech Business Week ...
2009 NOV 9 ... were analyzed by Western blot. overexpression of PDZ-RhoGEF, but not p115-RhoGEF or leukemia-associated RhoGEF (LARG), enhanced RhoA activation by angiotensin II. Knockdown of ... "Ras homolog gene family member A (RhoA)/Rho-kinase-mediated Ca2+ sensitization is a critical component of ... Angiotensin, Arteriosclerosis, Biotechnology, Cardiology, Enzyme Research, Gene Therapy, Kinase, Phosphatase, Protein Signal, Proteins, Proteomics, Thrombosis, Tyrosine Kinase, ...
2009 NOV 23 ... have a role in the progression of myelodysplastic syndromes (MDS) into acute myeloid leukemia (AML). Indeed, recent studies showed that phosphoinositide-phospholipase (PI-PL) Cbeta1 ... inhibitor currently used in MDS, displayed a direct correlation between PI-PLCbeta1 gene expression and drug responsiveness. Consequently, we hypothesized that PI-PLCbeta1 could ... Consequently, we hypothesized that PI-PLCbeta1 could be a target for demethylating therapy. First, we analyzed the structure of PI-PLCbeta1 gene promoter, then quantified the ...
2009 NOV 9 ... "Burkitt lymphoma/leukemia (BL) has become a very curable mature B-cell neoplasm. Current standard regimens, ... population. Future improvements for patients with BL could rely on standardization of gene expression profiling (to ensure more accurate diagnoses and prognostication of disease ... benefit and are not recommended. The more widespread use of highly active antiretroviral therapy in the HIV patient with BL has allowed the use of similar aggressive therapies that are ...
2009 NOV 27 ... in patients with a form of blood cancer, known as T-ALL or T-cell acute lymphoblastic leukemia.Abnormal NOTCH genes found in cancer patients remain in a state of constant ... as an oncologist, Bradner became deeply interested in a human protein called NOTCH. The gene encoding this protein is often damaged, or mutated, in patients with a form of blood ... published in the November 12 issue of Nature, lays the foundation for a new kind of therapy aimed directly at a critical human protein - one of a few thousand so-called ...
2009 NOV 9 ... in cancer therapy to suppress malignantly proliferative cell types, such as adult T-cell leukemia (ATL) cells. In this study, we examined the feasibility of employing the HIV-vpr gene, ...
2009 NOV 9 ... "At the incipient stages of the development of adult T-cell leukemia, T-cells infected with human T-cell leukemia virus type 1 (HTLV-1) suffer disregulation ... of these transcriptional factors presumably contributes to expression of the IL-21 gene and its receptor gene. The related virus HTLV-2 with Tax2 similar to Tax1 is known not ... Keywords: Japan, Tokyo, Adenoviridae, Biological Chemistry, Biotechnology, Gene Therapy, Hematology, Human T-Lymphotropic Virus, Oncology, T-Cell Leukemia, Viral Research, ...
2009 NOV 9 ... contact S. Verstovsek, University of Texas MD Anderson Cancer Center, Dept. of Leukemia, 1515 Holcombe Blvd., Houston, TX 77030, USA. The publisher of the journal ... "Thus, effective, targeted therapies are needed. A mutated Janus kinase 2 (JAK2) gene (JAK2(V617F)), found in a significant portion of patients with MPN, results in increased ... Neoplasms, Oncology, Polycythemia Vera, Proteins, Proteomics, Stem Cell Research, Therapy, Treatment, Tyrosine Kinase, University of Texas. This article was prepared ...
2009 NOV 16 ... people each year in the United States, and that sometimes results in acute myeloid leukemia. Researchers found that the gene RhoB is important to the disease's progression and ... Myelodysplastic Syndromes, Myeloid Leukemia, Oncology, Solid Cancers, Solid Carcinomas, Therapy, Treatment. This article was prepared by Biotech Business Week editors from ...
