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2009 NOV 9 ... of the University of Pennsylvania, who is widely recognized for his outstanding work in lipid research and lipoprotein metabolism," said Victor Kotelianski, M.D., Ph.D., D.Sc., ... working with Alnylam as leaders in the RNAi therapeutics field. Our knowledge of lipid disorders and their association with human disease combined with Alnylam's expertise of ...
2009 SEP 14 ... Bile acids are known to be key regulators of lipid, glucose and overall energy metabolism. Bile acid activation of the G protein-coupled ... for its potential as a novel treatment in diabetes, obesity and associated metabolic disorders. INT-777 is a patent-pending modified human bile acid that is currently being advanced ...
2009 OCT 26 ... the Monell Center and the Mount Sinai School of Medicine, certain common herbicides and lipid-lowering fibrate drugs act in humans to block T1R3, a nutrient-sensing taste receptor ... the release of hormones involved in the regulation of glucose homeostasis and energy metabolism. "Compounds that either activate or block T1R3 receptors could have ... blocking T1R3. Fibrates are a class of drugs frequently used to treat lipid disorders such as high blood cholesterol and triglycerides. Phenoxy-herbicides are used in ...
2009 SEP 7 ... understood but could be related to inflammation, lipotoxicity and oxidative stress. Lipid peroxides have been proposed as key mediators of intracellular metabolic response," ... "The mechanism, by which a high-fat (HF) diet could impair glucose metabolism, is not completely understood but could be related to inflammation, lipotoxicity and ... peroxidation in key organs is not necessarily related to the development of metabolic disorders associated with diabetes and obesity.." Sohet and colleagues published ...
2009 NOV 23 ... of coronary artery disease and associated metabolic syndromes. The compound targets lipidmetabolism in two ways: first, by inhibiting fatty acid and cholesterol synthesis; and ... programs in both acute and chronic therapies to treat cardiovascular and metabolic disorders," Mr. Newton added. Keywords: Angiology, Biotechnology, Cardiology, ...
2009 NOV 30 ... of coronary artery disease and associated metabolic syndromes. The compound targets lipidmetabolism in two ways: first, by inhibiting fatty acid and cholesterol synthesis; and ... programs in both acute and chronic therapies to treat cardiovascular and metabolic disorders," Mr. Newton added. About Esperion Therapeutics Esperion ...
2009 NOV 9 ... to be a key factor underlying fat loss, while inhibition of adipocyte development and lipid deposition may also contribute. Both tumor and host-derived factors are implicated in ... molecular mechanisms remain to be established, evidence suggests that altered adipocyte metabolism may lead to adipose atrophy in cancer cachexia. Increased lipolysis appears to be a key ... Adolescent Medicine, Alternative Medicine, Anorexia, Atrophy, Cachexia, Cancer, Eating Disorders, Experimental Model, Fibrosis, Hepatology, Metabolism, Neurology, Oncology, Therapy, ...
2009 NOV 2 ... Moreover, stress-resistant cells exhibited reduced SMase activity. The altered lipidmetabolism was associated with enhanced autophagy. Treatment of stress-resistant cells ... "Chronic oxidative stress has been causally linked to several neurodegenerative disorders. As sensitivity for oxidative stress greatly differs between brain regions and neuronal ...
2009 NOV 9 ... Current study results from the report, 'Short term effects of spironolactone on blood lipid profile: a 3-month study on a cohort of young women with hirsutism,' have been ... For additional information, contact M. Nakhjavani, Vali-Asr Hospital, Endocrinology and Metabolism Research Centre (EMRC), Tehran, Iran. Publisher contact information for the ... hirsutism with spironolactone, special care should be given to women with metabolic disorders such as dyslipidaemia." Nakhjavani and colleagues published their study in ...
2009 SEP 14 ... Prolonged PEDF administration stimulated adipose tissue lipolysis, resulted in ectopic lipid deposition, and reduced insulin sensitivity, while neutralizing PEDF in obese mice ... Crowe and colleagues published the results of their research in Cell Metabolism (Pigment Epithelium-Derived Factor Contributes to Insulin Resistance in Obesity. Cell ... is a major risk factor for insulin resistance; however, the factors linking these disorders are not well defined. Herein, we show that the noninhibitory serine protease inhibitor, ...
2009 NOV 16 ... mice three times per week for 3 months led to a significant reduction in the amounts of lipid in the liver as well as in serum insulin. Tacrolimus treatment also ameliorated ... chronic hepatitis C, in which oxidative stress and abnormalities in lipid and glucose metabolism contribute to liver pathogenesis. (Am J Pathol 2009, 175:1515-1524; DOI: ... by hepatitis C virus (HCV) infection. In the pathogenesis of liver disease and metabolic disorders in HCV infection, oxidative stress due to mitochondrial respiratory chain dysfunction ...
2009 SEP 28 ... patients on body composition and A-FABP plasma levels. Parameters of glucose and lipidmetabolism as well as plasma levels of leptin and A-FABP were prospectively assessed in ... during refeeding of female patients with anorexia nervosa' new findings in eating disorders. "Adipocyte fatty acid binding protein (A-FABP) has been suggested to play an important ...
2009 OCT 13 ... "The nuclear receptor PPAR alpha is activated by drugs to treat human disorders of lipidmetabolism. Its endogenous ligand is unknown," scientists in the United States report. ...
2009 OCT 5 ... New research, 'Lipid mediators in the neural cell nucleus: their metabolism, signaling, and association with ... the neural cell nucleus: their metabolism, signaling, and association with neurological disorders,' is the subject of a report. "Lipid mediators are important endogenous regulators of ...
2009 NOV 2 ... changes expression of certain regulatory proteins and enzymes involved in glucose and lipidmetabolism," wrote S.H. Chiang and colleagues, University of Michigan. The ... for obesity, insulin resistance, diabetes, and other complications associated with these disorders." Chiang and colleagues published their study in Cell (The Protein Kinase ...
2009 NOV 9 ... "Lipid abnormalities are a common complication of kidney transplantation, occurring in up to ... kidney transplantation, occurring in up to 60% of patients. In fact, impairment of lipid metabolism is often present before renal transplantation due to the uremic state," scientists in ... the role of immunosuppressive drugs, and current recommendations to manage lipid disorders in renal transplant recipients." Badiou and colleagues published their ...
2009 OCT 5 ... the protein invadolysin, which is essential for healthy cell division, is present in lipid droplets - the parts of cells used to store fat. The study also found that ... storage was impaired. Further studies will look at how the protein affects metabolism to better understand its role in obesity-related disorders. Keywords: ...
2009 NOV 16 ... of the cells in the body. Moreover, schlank also has a regulatory function. It promotes lipid synthesis and at the same time inhibits the mobilisation of fat from the fat reserves. ... University of Bonn have discovered a previously unknown fruit fly gene that controls the metabolism of fat. Larvae in which this gene is defective lose their entire fat reserves. Therefore ... important for animals. Mutations in the corresponding genes lead to severe metabolic disorders and to malfunctions of organ systems. That is why our Lass genes look surprisingly ...
2009 NOV 23 ... widely used in the treatment of metabolic disorders, especially hyperlipemia, due to its lipid-lowering effect. The molecular mechanism of lipid-lowering is relatively well defined: ... a PPAR-RXR heterodimer and this regulates the transcription of genes involved in energy metabolism by binding to PPAR response elements in their promoter regions, so-called ...
2009 NOV 16 ... target proteins. Consequently, zinc deprivation caused cellular accumulation of lipid droplets, triglycerides and free fatty acids in the HepG2 cells," wrote Y.Q. Kang and ... activated receptor-alpha (PPAR-alpha). Zinc supplementation enhanced alcohol metabolism and attenuated oxidative stress and liver injury. Zinc supplementation also normalized ... Biochemical, Endocrinology, Gastroenterology, Hepatology, Mental Health, Metabolic Disorders, Steatosis, University of Louisville, Medical Department. This article was ...
