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2009 OCT 12 ... and Aggregation In silico tools and in vitro HTS approaches to determine lipophilicity during the drug discovery process Membrane permeability - measurement and ...
2009 NOV 2 ... along with computational studies showed that the most active compound (9) possessed low lipophilicity (AlogP=0.59) and high solubility (logS = -1.33)." Alyar and colleagues ...
2009 NOV 2 ... compounds with a low probability of producing relevant in vivo drug interactions. Drug lipophilicity was identified as the primary determinant of in vitro binding to colesevelam by the ...
2009 NOV 24 ... phases." Casoni and colleagues published their study in Chromatographia (Lipophilicity of Some Preservatives Estimated by RP-TLC Using Stationary Phases with Different ...
2009 OCT 12 ... researchers in the United States report. "The data set indicated that lipophilicity shows a negative relationship while polar descriptors show a positive relationship with ...
2009 NOV 16 ... normal and pRBC is higher than that of CQ, in agreement with the lower pK(a) and higher lipophilicity of the compounds. AM1 or AP4b is not hemolytic per se and is less hemolytic than CQ when ...
2009 NOV 9 ... journal Anesthesia and Analgesia, "Cardiac toxicity significantly correlates with the lipophilicity of local anesthetics (LAs). Recently, the infusion of lipid emulsions has been shown to ...
2009 OCT 20 ... of human apo A-I, particularly its C-terminus relative to mouse apo A-I, and the higher lipophilicity of human apo A-II. The SOF-catalyzed reaction is the first to target HDL rather than its ...
2009 OCT 6 ... alter its physicochemical properties with respect to biological activity, stability and lipophilicity. Accordingly, this element is found in many pharmaceutical and industrial chemicals." ...
2009 OCT 19 ... new oxygen carrier perfluorohexyloctane (F6H8) characterized by lower gravity and higher lipophilicity than PFD. Subsequent to 24 h of storage in either oxygenated PFD or F6H8, the rat ...
2009 NOV 2 ... A, Benz A, Covey DF, Zorumski CF, Mennerick S. The influence of neuroactive steroid lipophilicity on GABA(A) receptor modulation: evidence for a low-affinity interaction. J Neurophysiol ...
2009 NOV 16 ... effect of each other in the patients with both diseases. Trospium has a relatively low lipophilicity and low CNS penetration, and galantamine, a cholinesterase inhibitors, has also ...
2009 OCT 5 ... the permeation coefficient of [Leu(5)]-enkephalin. This could be due to an increase in lipophilicity caused by the organometallic label. The metal-peptide conjugates were found to be ...
2009 OCT 19 ... The researchers concluded: "The QSAR analyses did not indicate any role for lipophilicity Electrostatic potential, dipole moment and the bulk, primarily affect the biological ...
2009 OCT 20 ... differing phases. Dipole interactions of analytes (possessing dipole moments and low lipophilicity) with CN phases were primarily responsible for the elution order," researchers in the ...
2009 OCT 19 ... in the radiotracer uptake in the tumor and normal organs most likely due to the higher lipophilicity of (TcO)-Tc-99m(MAG(2)-3P-RGD(2)) (log P = -3.15 +/- 0.10) than that for ...
2009 NOV 1 ... of [(14)C]efavirenz and [(3)H]nevirapine." "We also investigated the lipophilicity of [(14)C]efavirenz and [(3)H]nevirapine. The expression of P-gp, MRP1, MRP2, SLCO1A2, ...
2009 NOV 23 ... model drug to a series of synthetic counter-ionic entities with a controlled degree of lipophilicity in order to enhance its penetration of biomembranes and offer some protection against in ...
2009 NOV 1 ... is restricted to locales that are in proximity to aquatic ecosystems. Because of the lipophilicity and persistence of polychlorinated biphenyls (PCBs) and reliance of mink on ...
