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2009 AUG 31 ... Susceptibility to atherosclerosis from severe hypertriglyceridemia (HTG) resulting from lipoproteinlipase (LPL) deficiency has been demonstrated in Our recent findings which employed a ... Compared with EKO mice, the expression of von Willebrand factor (vWF) and plasminogen activator inhibitor type 1 (PAI-1) were increased in DKO mice," wrote X.D. Xian and colleagues, ...
2009 MAR 2 ... are differentially expressed during the process of adipogenesis (e.g., adiponectin and lipoproteinlipase), we identified several proteins whose differential expression during adipocyte ... documented previously. For example, THO complex 4, a context-dependent transcriptional activator in the T-cell receptor alpha enhancer complex, showed highest expression at middle stage ...
2009 NOV 23 ... "Metformin is known to increase lipoproteinlipase (LPL) mass level in scrum. Lipoproteinlipase is produced by adipose tissue and ... cells. To clarify the mechanism of this phenomenon, AICAR, which is well known as an activator of adenosine monophosphate-activated protein kinase (AMPK), was used. Metformin and ...
2007 AUG 28 ... diabetes knowledge.
Study 1: A new study, "Triglyceride uptake and lipoproteinlipase-generated fatty acid spillover in the splanchnic bed of dogs," is now available. ... to minimize naturally occurring oxysterols. D-glucose and GW3965 (a synthetic LXR activator) induced similar changes in hepatic gene expression, indicating that LXR functions as a ...
2007 OCT 8 ... protein 4 (angptl4) is mainly secreted from adipose tissue and inhibits lipoproteinlipase activity. The expression and plasma levels of angptl4 are increased by fasting. ... ERK1/2. Use of the JNK inhibitor SP600125 or expression of dominant-negative JNK-activator SAPK kinase (SEK1) prevented the induction of ATF2-Thr69+71, but not ATF2-Thr71 ...
2008 DEC 9 ... with E3030 at a dose of 0.03 mg/kg or greater showed remarkable TG- and non high-density lipoprotein (non-HDL) cholesterol-lowering effects in beagle dogs. These results were similar to ... E3030 also reduced apo C-III levels on Days 7 and 14, and elevated lipoprotein lipase (LPL) levels on Day 15. These results indicate that the TG- and non-HDL ... Japan, "We investigated the antidiabetic effects of E3030, which is a potent dual activator of peroxisome proliferator-activated receptor (PPAR) alpha and PPAR gamma, in an animal ...
2007 AUG 14 ... lipid metabolism. The aim of this study was to investigate the long-term effect of the lipoprotein lipase activator, NO-1886, on inflammation cytokines, adiposity and related diseases in miniature pigs ...
2008 FEB 25 ... published their study in the Journal of Lipid Research (Appraisal of hepatic lipase and lipoproteinlipase activities in mice. Journal of Lipid Research, 2007;48(12):2788-2791).
... the same assay conditions ( low salt and the presence of apolipoprotein C-II as an LPL activator)," wrote G.M. Dallingathie and colleagues.
The researchers concluded: ...
2007 OCT 29 ... A report, 'Atorvastatin decreases lipoproteinlipase and endothelial lipase expression in human THP-1 macrophages,' is newly ... decreased LPL and EL expression in the presence or absence of atorvastatin. Another Rho activator, farnysyl pyrophosphate, decreased EL expression only in the absence of atorvastatin. ...
2007 SEP 4 ... Cardiology, Cardiovascular Disease, Diet & Nutrition, Dyslipidemia, Genetics, Genomics, Lipoprotein, Metabolism, Risk, Treatment, Vascular Disease.
This article was prepared ... "Several genes (e.g., apolipoprotein A-I and A-IV, apolipoprotein E, and hepatic lipase) are providing proof-of-concept for the application of genetics in the context of ... metabolism and especially those transcription factors (i.e., peroxisome proliferator activator receptors) that act as sensors of nutrients in the cell (e.g., polyunsaturated fatty ...
2008 JUN 30 ... in wild-type mice."
"In these mice, messenger RNA (mRNA) expression of lipoproteinlipase, which catalyzes hydrolysis of TG, is downregulated. In the present study, we ... In the present study, we focused on adipocytokines, especially plasminogen activator inhibitor-1 (Pai-1), which is involved in hyperlipidemic status and may promote ...
2007 OCT 8 ... lipid metabolism. The aim of this study was to investigate the long-term effect of the lipoprotein lipase activator, NO-1886, on inflammation cytokines, adiposity and related diseases in miniature pigs ...
2008 JUL 21 ... in the mRNAs for proteins involved in lipolysis such as hormone-sensitive lipase, lipoproteinlipase, adipose tissue triglyceride lipase, and FAT/CD36. The relative distribution of ... angiotensin II receptor 1, butyrylcholinesterase, lipocalin 2, and plasminogen activator inhibitor 1. The cells in the adipose tissue matrix were enriched at least 3-fold as ...
2007 JUL 30 ... identify developing directions of research.
Study 1: Research findings, "Lipoprotein lipase activator ameliorates the severity of dietary steatohepatitis," are discussed in a new report. ...
Subject: Chinese University of Hong Kong, People's Republic of China
2007 JUL 30 ... from the People's Republic of China has reported that localized vessel expression of lipoproteinlipase (LPL) in rabbits leads to rapid lipid deposition in the balloon-injured arterial ... present study examined the correlation between variants in the d-amino acid oxidase activator (DAOA) locus and clinical symptoms and response to antipsychotics in schizophrenia. ...
Subject: Peking University, People's Republic of China
2007 AUG 14 ... Cardiology, Cardiovascular Disease, Diet & Nutrition, Dyslipidemia, Genetics, Genomics, Lipoprotein, Metabolism, Risk, Treatment, Vascular Disease.
This article was prepared ... "Helicobacter pylori EstV: identification, cloning, and characterization of the first lipase isolated from an epsilon-proteobacterium," have been published. "Bacterial lipases are ... metabolism and especially those transcription factors (i.e., peroxisome proliferator activator receptors) that act as sensors of nutrients in the cell (e.g., polyunsaturated fatty ...
