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2009 NOV 3 ... indicating a critical function(s) for the AP-1 machinery. Transport of soluble and membrane-bound secretory cargoes was Tb mu 1 independent in both stages. In procyclic parasites, ... in both stages. In procyclic parasites, trafficking of the lysosomal membrane protein, p67, was disrupted, leading to cell surface mislocalization. The lysosomal protease ...
2009 SEP 15 ... "Autophagy is a membrane-trafficking process that serves to deliver cytoplasmic proteins and organelles to the ... defined, including the Damage-Regulated Autophagy Modulator (DRAM), which is a lysosomal protein that links autophagy and the tumor suppressor, p53. We describe here analysis of ...
2009 SEP 15 ... "The role of plasma membrane (PM) area as a critical factor during cell motility is poorly understood, mainly due to ... parameters. We observed that Golgi, lysosomes, and glycosylphosphatidylinositol-anchored protein vesicles are exocytosed during spreading, but endoplasmic reticulum and transferrin ...
2009 OCT 19 ... drugs. Ambroxol (ABX), a drug used to treat airway mucus hypersecretion and hyaline membrane disease in newborns, was identified and found to be a pH-dependent, mixed-type inhibitor ... ABX treatment significantly increased N370S and F213I mutant GCase activity and protein levels in GD fibroblasts. These increases were primarily confined to the ...
2009 OCT 19 ... However, F1 does not fully enter the lysosome but remains associated with the lysosomal membrane," wrote Y. Wang and colleagues, . The researchers concluded: "Inefficient ... to the nucleation of Tau paired helical filaments. Clearance of the abnormally modified protein could occur by the ubiquitin-proteasome and autophagy-lysosomal pathways, the two major ...
2009 NOV 1 ... is sensitive to cationic antibiotics and peptides, shows increased association with lysosome-associated membrane protein-positive vesicles, and it exhibits altered membrane potential compared to wild type. A ...
2009 SEP 21 ... Vpu targets, we performed quantitative proteomics analyses using the plasma membrane fraction of HeLa cells expressing either wild-type Vpu or a Vpu mutant (S52N/S56N) that ... "The primary roles attributed to the human immunodeficiency virus type 1 (HIV-1) Vpu protein are the degradation of the viral receptor CD4 and the enhancement of virion release. ...
2009 OCT 12 ... According to recent research from the United States, "Cancer cell membrane proteins are released into the plasma/serum by exterior protein cleavage, membrane ...
2009 NOV 27 ... in neurons using lentiviral delivery of interfering RNA leads to enlargement of a lysosome-associated membrane protein 1-positive membrane compartment with no obvious influence on the CCV machinery at the ...
2009 NOV 1 ... sections were immuno-stained for CD1a to mark immature DCs, and for CD83, fascin, and DC-lysosome-associated membrane protein (DC-LAMP) to delineate mature DCs. The volume density (ie, the volume of DCs as the ...
2009 OCT 19 ... with a C-terminally His-tagged NCU-G1 and the lysosomal marker LAMP-1 (lysosome-associated membrane protein-1) as a reference. and by subcellular fractionation of mouse liver after a ...
2009 NOV 1 ... pathogens, like Chlamydia and Legionella, must contend with vesicular trafficking and membrane fusion in the host cell. But they manage to bypass the lysosome, where other pathogens ... alter membrane fusion to their advantage. The Chlamydia bacteria expressed a SNARE-like protein called IncA and the Legionella expressed a SNARE-like protein called IcmG/DotF, both of ...
2009 OCT 27 ... adaptor protein (AP)-3 complex defines a pathway for the intracellular trafficking of membrane-associated proteins in most eukaryotic cells." "Ten years ago, genetic ...
2009 OCT 13 ... also induces compression and propulsion. We show that dynamic interactions between membrane elastic tension and compression forces of polymerizing actin can also lead to ... actin dynamics in live macrophages expressing actin tagged with green fluorescent protein (GFP). We show that only immature phagosomes can transiently induce assembly of actin ...
2009 SEP 22 ... "The CTNS gene consists of 12 exons and encodes for an integral lysosomal membraneprotein with seven transmembrane domains. A majority of cystinotic patients are of ...
2009 NOV 3 ... an miRNA effector protein, argonaute 2 (AGO2), was initially identified as membrane-associated, and some miRNAs have been found in secreted vesicles (exosomes) that derive ...
