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2009 NOV 23 ... indicated that quercetin promoted apoptosis-inducing factor (AIF) release from mitochondria and stimulated translocation to the nucleus," wrote S.Y. Chien and colleagues. ... species generation but increased cytosolic Ca2+ levels and reduced the mitochondrial membranepotential (Delta Psi(m)). Quercetin treatment promoted activation of caspase-3, -8 and ...
2009 NOV 23 ... and translocation of apoptosis-inducing factor as well as endonuclease G from the mitochondria to the nucleus. Additionally, alpha-ESA caused a G(2)-M block in the cell cycle. We also ... for control untreated cells. Addition of alpha-ESA also caused loss of mitochondrial membranepotential and translocation of apoptosis-inducing factor as well as endonuclease G from ...
2009 NOV 16 ... assay. HCT increased reactive oxygen species production and decreased the levels of mitochondria membrane potential (MMP) in HT-29 cells by flow cytometry analysis. HCT caused the release of cytochrome c, ...
2009 NOV 16 ... in vitro GC analog [dexamethasone (DX)] treatment, the GR translocates into the mitochondria but not into the nucleus in DP cells. We also analyzed the GR redistribution in ... fraction of the GR translocates into the mitochondria. DX reduced the mitochondrial membranepotential of DP cells within 30 min, measured by flow cytometry, which refers to a ...
2009 NOV 9 ... scientists in London, the United Kingdom report. "Using isolated mitochondria, we found that synthetic peptides containing the C-terminus part of the M ectodomain ... Dengue virus infection triggers apoptosis especially through the expression of the small membrane (M) protein," scientists in London, the United Kingdom report. "Using ... events include matrix swelling and the dissipation of the mitochondrial transmembrane potential (Delta I-m). Protein M Flavivirus sequence alignments and helical wheel projections ...
2009 NOV 26 ... these fatty acids were shown to increase the translocation of Bad and Bax to the mitochondria, increase mitochondrial membrane permeability, and induce the release of cytochrome c ... Bax to the mitochondria, and the subsequent disruption of normal mitochondrial membrane potential."Cho and colleagues published their study in the Journal of Medicinal Food ...
2009 NOV 9 ... that 6-OHDA induced intracellular reactive oxygen species generation and decreased the mitochondria membrane potential (Delta Im). These effects could be partially reversed by RA pretreatment. However, RA ...
2009 NOV 16 ... (DPI), an inhibitor of NADPH oxidase. TW-92 induced swelling of isolated rat liver mitochondria, indicative of a direct effect on mitochondria. Apoptosis in intact cells was ... mitochondria. Apoptosis in intact cells was accompanied by a decrease in mitochondrial membranepotential, cytochrome c release and caspase activation. In addition, the level of Mcl-1, ...
2009 NOV 24 ... Exogenous STC1 is internalized by macrophages within 10 min and localizes to the mitochondria, suggesting a role for circulating and/or tissue-derived STC1 in regulating macrophage ... I-IV. STC1 induces the expression of mitochondrial UCP2, diminishing mitochondrial membranepotential and superoxide generation; studies in UCP2 null and gp91phox null macrophages ...
2009 NOV 9 ... of G2/M cells. Also, the ratio of Bax/Bcl-2 was increased leading to changes in mitochondria membrane potential (Delta Psi(m)) and release of cytochrome c, whereas the baicalein-induced apoptosis was ...
2009 NOV 16 ... excess reactive oxygen species (ROS) production and exerts a deleterious effect on mitochondria. We have shown previously that activation of AMP-activated protein kinase (AMPK) ... to cell survival, as supported by the reversal of its restoration of mitochondrial membranepotential by either overexpression of a dominant-negative mutant of AMPK alpha or ...
2009 NOV 9 ... then subjected to 30 min stop-flow ischemia or ischemia/reperfusion. Isolated heart mitochondria were used to measure the rate of mitochondrial oxygen consumption and membranepotential ...
2009 NOV 9 ... that siccanin was effective against enzymes from P. aeruginosa, P. putida, rat and mouse mitochondria but ineffective or less effective against Escherichia coli, Corynebacterium glutamicum, ... screening of a structurally varied natural compound library with Pseudomonas aeruginosa membrane-bound respiratory enzymes. We identified a succinate dehydrogenase inhibitor, siccanin ... by siccanin is unique among succinate dehydrogenase inhibitors, and thus siccanin is a potential lead compound for new chemotherapeutics." Mogi and colleagues published ...
2009 NOV 9 ... was abrogated in the presence of allopurinol and DPI, but not by rotenone, discarding mitochondria as a ROS source. In addition, sPLA(2)-IIA triggered Ras and Raf-1 activation, with ... injury. We have previously demonstrated that exogenous sPLA(2)-IIA, by engagement to a membrane structure, induces proliferation and activation of mitogen-activated protein kinases ... of Valladolid. The researchers concluded: "Our results reveal new potential targets for therapeutic intervention in neuroinflammatory disorders and brain cancer in ...
2009 NOV 2 ... "Our findings demonstrate that VK3-induced apoptosis is selectively initiated by the mitochondria-related pathway and might be useful in breast cancer chemotherapy." ... that VK3 caused mitochondrial dysfunction including a disappearance of mitochondrial membranepotential. Additional investigation showed that the mitochondrial damage was induced by ...
2009 NOV 2 ... Data detailed in '12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress' have been presented. According to a study from the United ... the cell to die. Importantly these events, including breakdown of the mitochondrial membranepotential, the production of reactive oxygen species, and cytochrome c release, can all ...
2009 NOV 16 ... triphosphate (ATP) content, which is preserved by preconditioning." "Mitochondria being the main ATP production source for the cell, we aimed to evaluate whether ischemic ... (ALT) and aspartate aminotransferase (AST) levels were measured. Mitochondrial membranepotential, mitochondrial respiration and susceptibility to mitochondrial permeability ...
2009 NOV 1 ... data on life sciences are presented in the report 'Sevoflurane and propofol depolarize mitochondria in rat and human cerebrocortical synaptosomes by different mechanisms.' "The ... and human cerebrocortical synaptosomes by different mechanisms.' "The mitochondrial membranepotential drives the main functions of the mitochondria. Sevoflurane depolarizes neural ...
2009 NOV 10 ... to the surrounding supporting cells within the cochlear epithelium." "Mitochondria are key regulators of cytoplasmic Call concentration ([Ca2+](cyt)), and yet little is ... calcium. Blocking mitochondrial Ca2+ uptake by dissipating the mitochondrial membranepotential using CCCP and oligomycin or using Ru360, an inhibitor of the mitochondrial ...
