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2009 MAR 23 ... implications of these changes in hepatic atRA levels on cell proliferation in the mousetumorigenesis process are discussed," wrote P.J. Chen and colleagues, Environmental ... in vivo. The in vitro metabolism of atRA was metabolism, quantitatively measured in liver microsomes from male CD-1 mice following four daily intraperitoneal injections of ...
2009 JAN 26 ... tumors are also present in the murine model for Ptch1 deficiency, the Ptch1(neo67/+) mouse," scientists in Munich, Germany report.
"Previous studies, ... Foxf1, Gli1, Bmi1 and Notch2 were detected in a variety of adult mouse tissues, such as liver, kidney, spleen, lung. heart and brain," wrote D.S. Wendling and colleagues, ... of human and murine origin. We report on a more common role of Foxf1 in Ptch1-associated tumorigenesis. Since we found a striking up-regulation of Foxf1 expression in Ptch1-associated BCC and ...
2009 JUL 27 ... compared with parental MiaPaCa-2 cells and induced liver metastasis in an orthotopic mouse model. The metastatic phenotype induced by IL-1 alpha was inhibited by the expression of ... of constitutive NF-kappa B activation in pancreatic cancer cell lines suppresses tumorigenesis and tumor metastasis," scientists writing in the journal Molecular Cancer Research ...
2009 MAY 25 ... of alpha-smooth muscle actin and transforming growth factor-beta during in vitro mouse HSC activation."
"Both cathepsins are necessary for HSC ... have been best characterized in tumorigenesis and cell death and implicated in liver fibrosis; however, whether cathepsins directly regulate hepatic stellate cell (HSC) ...
2009 NOV 9 ... steps in tumorigenesis and the acquisition of hallmark capabilities in a prototypical mouse model of cancer," scientists in Lausanne, Switzerland report. "Metastases ... in primary tumors, while altering expression of metastatic signature miRs similarly to liver metastases, suggesting their involvement in adaptive resistance to anti-angiogenic ...
2009 AUG 17 ... with direct targeting of cyclins D2 and E2. Systemic administration of this miRNA in a mouse model of HCC using adeno-associated virus (AAV) results in inhibition of cancer cell ... behavior. In this study, we investigated the efficacy of a miRNA replacement therapy for liver cancer." "We demonstrate that hepatocellular carcinoma (HCC) cells ... the results of their research in Cell (Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model. Cell, 2009;137(6):1005-1017). For ...
2009 JAN 26 ... relevant to human cancer, we compiled pools of short hairpin RNAs (shRNAs) targeting the mouse orthologs of genes recurrently deleted in a series of human hepatocellular carcinomas ... study in Cell (An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer. Cell, 2008;135(5):852-864).
For additional information, contact ... in a series of human hepatocellular carcinomas and tested their ability to promote tumorigenesis in a mosaic mouse model," researchers in the United States report.
...
2009 JUL 13 ... "However, their nature and origin remain elusive. To isolate and characterize mouse oval cells, we searched for cell surface molecules expressed on oval cells and analyzed ... cells (HSCs) that differentiate into hepatocytes and cholangiocytes in severely injured liver. Hepatic oval cells have also been implicated in tumorigenesis," scientists writing in ...
2009 FEB 23 ... activated beta-catenin can cooperate with c-Met to induce liver cancer formation in it mouse model," scientists in the United States report.
"Cyclin DI (CCND1) ... in CCND1-null tumor samples, indicating that CCND2 may replace CCND1 in hepatic tumorigenesis. Together, our results suggest that CCND1 functions as a mediator of P-catenin during ...
2009 MAR 9 ... active version of Stat3alpha (Stat3alphaC) may also suppress transformation. Mouse embryonic fibroblasts (MEFs) deficient for p53 can be transformed with either c-myc or ... mice. The leukemic cells invaded multiple organs including lung, heart, salivary glands, liver and kidney. Interestingly, transplanted mice developed a similar leukemia when the bone ... "Stat transcription factors have been implicated in tumorigenesis in mice and men. Stat3 and Stat5 are considered powerful proto-oncogenes, whereas Stat1 ...
2009 JUL 27 ... National University. The researchers concluded: "This transgenic mouse model provides a useful system that allows the study of the physiologic effects of ... hepatocellular carcinoma. To study the phenotypic effects of Aurora-A overexpression on liver regeneration and tumorigenesis, we generated transgenic mice overexpressing human ...
2008 JUN 16 ... that DLC1 was causally implicated in specific cancers, the team genetically engineered mouseliver cells in which the gene was not expressed. Short-hairpin RNAs (shRNAs) were ... the experimental road, for it is not simply the absence of the DLC1 protein that causes tumorigenesis. In fact, abnormally low levels of the protein, or its complete absence, induces a ...
2008 SEP 1 ... concert to more efficiently promote tumorigenesis. Genes not previously associated with mouse liver tumorigenesis exhibited altered methylation at these very early times following PB treatment," wrote ...
2008 DEC 29 ... Research findings, 'Proliferation of human HCC cells and chemically induced mouseliver cancers requires JNK1-dependent p21 downregulation,' are discussed in a new ... "Further, JNK1 was required for human HCC cell proliferation in vitro and tumorigenesis after xenotransplantation. Importantly, mice lacking JNK1 displayed decreased tumor cell ...
2008 NOV 24 ... relative contributions of HIF-1 and HIF-2 to VHL-associated vascular tumorigenesis in a mouse model of liver hemangiomas. Here we demonstrate genetically that conditional ...
2008 OCT 20 ... we have silenced Snai2 and/or Snai1 by stable RNA interference in two independent mouse skin carcinoma (HaCa4 and CarB) cell lines. We demonstrate that Snai2 knockdown has a ... the metastatic ability of squamous carcinoma HaCa4 cells, inducing a strong reduction in liver and lung distant metastasis. However, only Snai1 knockdown has an effective action on ... a major role in tumor growth, invasion and metastasis, but the contribution of Snai2 to tumorigenesis is not yet well understood," investigators in Madrid, Spain report.
"To ...
2008 DEC 1 ... on grasses, fruits, grains, seeds, hardwoods, and conifers, Propiconazole is a mouseliver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and ... were less cytotoxic than the parent propiconazole, our results suggest that in the tumorigenesis process as tumor cells are formed they would be more susceptible to the cytotoxic ...
2008 SEP 8 ... test this idea, we generated transgenic mice overexpressing PIK3IP1 in hepatocytes in a mouse strain prone to develop HCC. Isolated PIK3IP1 transgenic mouse hepatocytes showed ... is known about the role of PIK3IP1 in normal and neoplastic growth in vivo. Proper liver function and development depend on intact PI3K signal transduction; when dysregulated, ... to dissect the contribution of PIK3IP1 to hepatic PI3K signaling in vivo and to liver tumorigenesis in particular, we formulated the following hypothesis: because PIK3IP1 down-regulates ...
2008 AUG 18 ... the United States, "Adenomatous polyposis coli (APC) mutations are linked to human and mouse colorectal cancers. The Apc multiple intestinal neoplasia (Min) mouse mutation causes ... the effect of the enterohepatic bacterial pathogen Helicobacter hepaticus on liver and intestine tumorigenesis in BALB-RagMin mice. H. hepaticus-infected BALB-RagMin mice ...
