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2009 AUG 17 ... to pathogenicity are currently not understood. Using the AcrAB-TolC system as a paradigm multidrug-resistant efflux pump and Salmonella enterica serovar Typhimurium as a model pathogen, ... data explain how mutants lacking a component of AcrAB-TolC are attenuated and that this phenotype is a result of decreased expression of numerous genes encoding proteins involved in ...
2009 NOV 2 ... According to a study from Florence, Italy, "The multidrug resistance (MDR) phenotype is characterized by the overexpression of a few transport ... and Functional Activity of Breast Cancer Resistance Protein in Different Multiple Drug-Resistant Cell Lines. Cancer Research, 2009;69(18):7235-7242). For additional ...
2009 JUL 27 ... Current study results from the report, 'Influence of multidrug resistance on (18)F-FCH cellular uptake in a glioblastoma model,' have been published. ... in Saint-Etienne, France report. "We used an in vitro multidrug-resistant (MDR) glioma model composed of sensitive parental U87MG and derived resistant cells ... U87MG-DOX: 1.33 +/-0.13) in line with accelerated choline metabolism and aggressive phenotype. FCH uptake is not influenced by the two ATP-dependant efflux pumps: Pgp and MRP1. FCH ...
2009 AUG 31 ... "Multidrug resistance, aggressiveness and accelerated choline metabolism are hallmarks of ... uptake," investigators in France report. "We used an in vitro multidrug-resistant (MDR) glioma model composed of sensitive parental U87MG and derived resistant cells ... U87MG-DOX: 1.33 +/- 0.13) in line with accelerated choline metabolism and aggressive phenotype. FCH uptake is not influenced by the two ATP-dependant efflux pumps: Pgp and MRP1. FCH ...
2009 SEP 14 ... of an efflux pump and PSE-1 beta-lactamase production is associated with the multidrug-resistantphenotype. The dominant use of a single class of antibiotics could have ...
2009 NOV 1 ... viruses to certain PIs. T74S is a bona fide accessory mutation, restoring fitness of multidrug-resistant viruses in both subtypes B and C," wrote E.A. Soares and colleagues, ... therapy. In this study, we assessed the impact of the protease substitution T74S on the phenotype and on the replicative fitness in HIV-1 subtypes B and C," scientists in Rio de ...
2009 NOV 16 ... "During investigation of susceptibility testing methods for polymyxins, 24 multidrug-resistant clinical isolates of Pseudomonas aeruginosa were observed to have a distinct, ... isolates of Pseudomonas aeruginosa were observed to have a distinct, reproducible phenotype in which skipped wells were observed during broth microdilution testing for polymyxin B. ...
2009 JUN 15 ... "The multidrug resistance (MDR) phenotype in cancer is closely related with the overexpression of ... of both tracers was evaluated in Small-cell lung cancer cell line H69 and in its drug-resistant sublines, H69LX4 and H69AR, overexpressing Pgp and MRP1, respectively. Studies were ...
2009 JUL 20 ... "Escherichia coli clonal group A (CGA) commonly exhibits a distinctive multidrug antimicrobial resistance phenotype-i.e., resistance to ampicillin, chloramphenicol, ... trimethoprim (ACSSuTTp)-and has accounted for up to 50% of trimethoprim-sulfamethoxazole-resistant E. coli urinary tract infections in some locales. Annotation of the whole-genome ...
2009 AUG 3 ... to a study from the United States, "To identify the apoptosis genes involved in the multidrug resistant phenotype of osteosarcoma. Multidrug resistant human osteosarcoma cell line (U-2 OS MR) and a drug ...
2009 JUN 15 ... "Some strains of non-multidrug-resistant, methicillin-resistant Staphylococcus aureus (nmMRSA) in Australia are likely ... infection and MSSA infection suggest that virulence is not correlated with resistance phenotype."
Tong and colleagues published their study in the Journal of ...
2009 JUL 13 ... target of rapamycin to both downregulate and disable the P-glycoprotein pump in multidrug-resistant B-cell lymphoma cell lines.' According to recent research from the United ... different types of human tumor cells in vitro. In certain cases, it can reverse the phenotype of multidrug resistant (MDR) cells." "However, there is limited ...
2009 JUL 27 ... emerged in many regions of the world. It is unknown if efflux systems contribute to the multidrug resistance phenotype." "The expression of genes encoding the efflux pump ... recent research from the United States, "Nosocomial isolates of Klebsiella pneumoniae resistant to all commonly used antimicrobial agents have emerged in many regions of the world. It ...
2009 AUG 24 ... Researchers detail in 'Identification of multidrug- and carbapenem-resistant Acinetobacter baumannii in Canada: results from CANWARD ... remained susceptible to the antimicrobials tested, however, 7.7% (n=2) displayed an MDR phenotype, including resistance to carbapenems. In one isolate bla(OXA-58) was found to be the ...
2009 APR 13 ... supports a role for horizontal gene transfer in the global dissemination of S. enterica multidrug resistance. Serovar Typhimurium isolates containing identical integrons with the gene ... Emerging Infectious Diseases, "Salmonella enterica bacteria have become increasingly resistant to antimicrobial agents, partly as a result of genes carried on integrons. Clonal ... investigated this resistance and integron carriage among 90 isolates with the ACSSuT phenotype (resistance to ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and ...
2009 OCT 5 ... for BRCA1-related breast cancer was associated with increased expression of the mouse multidrug resistance (Mdr1) genes, which encode the drug efflux transporter ATP-binding cassette ... tumor P-gp levels are below those found in some normal tissues, such as the gut. The resistantphenotype could be completely reversed by the third-generation P-gp inhibitor ...
2009 MAY 18 ... We have shown that this phenotype is due to the disruption of TgMSH-1 as the multidrug-resistance phenotype is complemented by a wild-type copy of TgMSH-1 and is recapitulated ... agents."
"Accordingly, mammalian cells lacking certain MSHs are resistant to chemotherapeutic drugs. Interestingly, we have discovered that the disruption of ...
2009 MAR 23 ... digestion, followed by PFGE and Southern blot hybridization. All isolates expressed a multidrug-resistantphenotype with some variability in the carbapenem susceptibility profile. The ...
2009 AUG 24 ... S1-nuclease-PFGE, polymerase chain reaction-based replicon typing, plasmid transfer and multidrug resistance profiling. Bla(CTX-M-15) (n=23; 51%) and bla(CTX-M-14) (n=11; 24%) were the ... of CTX-M-15-expressing strains in Norway are part of the global spread of multidrug-resistant ST131 and ST-complex 405, associated with ISEcp1 on transferrable IncFII plasmids.." ... (87%) displayed co-resistance to other classes of antibiotics. A transferable CTX-M phenotype was observed in 9/14 isolates," wrote U. Naseer and colleagues. The ...
