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2009 SEP 7 ... to acquire multipotency when cultured under appropriate culture conditions. These multipotent GS (mGS) cells have been known to differ from GS cells in their DNA methylation ... the DNA methylation status of the H19 imprinting control region (ICR) in multipotent adult germline stem (maGS) cells to elucidate how epigenetic imprints are altered by culture ... by bisulfite sequencing PCR of established maGS cells cultured in the presence of glial cell line-derived neurotrophic factor (GDNF) alone or both GDNF and leukemia inhibitory ...
2009 SEP 7 ... medicine has opened a new field of investigation. The search for sources to obtain multipotentstem cells from discarded tissues or through non-invasive procedures is of great ... the Journal of Translational Medicine (Human fallopian tube: a new source of multipotent adult mesenchymal stem cells discarded in surgical procedures. Journal of Translational ... all biological discards, are able to differentiate into muscle, fat, bone and cartilage cell lineages. The aim of this study was to isolate, expand, characterize and assess the ...
2009 AUG 31 ... beneficial outcome. These include the problem of inducing differentiation of multipotent grafted SCs into desired cell type, rejection of grafted SCs by the recipient's immune ... decreased the degree of reactive astrogliosis after traumatic brain injury in adult rats. Decrease of reactive astrogliosis leads to downregulation of glial scar formation. ... group from Serbia has begun preliminary experiments within a project aimed at Promoting stem cell graft survival in the model of traumatic brain injury in rats. One of the goals of ...
2009 OCT 12 ... of salivary gland stem/progenitor cells with self-renewal, high proliferation and multipotent differentiation activity in salivary glands, even after irradiation," wrote Y. ... occurs in most patients undergoing head and neck radiotherapy. It is unclear whether adult salivary gland tissue contains stem/progenitor cells." "In this study, we ... glands after irradiation. We developed a novel culture system that promotes single-cell colony formation with low density culture of irradiated and non-irradiated adult human ...
2009 OCT 12 ... The researchers concluded: "These data suggest that the derived hES-MC are multipotent cells with potential uses in tissue engineering and regenerative medicine and for ... and regenerative medicine and for providing a highly reproducible cell source for adult-like progenitor cells." Boyd and colleagues published their study in ... "Human embryonic stem cells (hESC) have the potential to produce all of the cells in the body. They are able ...
2009 SEP 14 ... been obtained from defined germline stem cells (GSCs) of mouse neonatal testis, only multipotentstem cells have been obtained so far from defined cells of mouse adult testis," ... so far from defined cells of mouse adult testis," scientists writing in the journal Cell Stem Cell report. "In this study we describe a robust and reproducible ...
2009 AUG 31 ... According to a study from the United States, "Multipotentadult progenitor cells (MAPCs) are nonhematopoietic stem cells capable of giving rise to ... after transplant." "In vitro, MAPCs potently suppressed allogeneic T-cell activation and proliferation in a dose-dependent, cell contact-independent, and ...
2009 SEP 14 ... mucosa, the organ of smell. These cells, accessible in humans from nasal biopsies, are multipotent and are able to make many cell types from all germ layers. They are easily grown in ... randomly orientated network of fine collagen Type II (CT2) fibers. AND PURPOSE: A useful adult tissue-derived stem cell is that from the olfactory mucosa, the organ of smell. These ...
2009 NOV 9 ... is an easily accessible tissue for use as a soft-tissue filler and source of adultmultipotent cells, called adipose-derived stem/stromal/progenitor cells. However, many aspects of ... assay, (3) multicolor flow cytometry (CD34, CD31, and CD45), and (4) adherent cell culture of stromal vascular fraction cells for viable adipose-derived stromal cell ...
2009 AUG 17 ... the limited source of autologous epidermal stem cells have led to more attention on the multipotentadult progenitor cells (MAPC). In this study, we examined the influence of the local ... functional reconstruction are two key aspects for treatment of skin injury. Research on cell source for skin repair has become a focus of study," scientists in Shanghai, People's ...
2009 SEP 7 ... "Multipotent mesenchymal stem cells (MSCs) hold great promise in regenerative medicine, but one of ... to stimulate the undifferentiated ex vivo expansion and preserve the pluripotency of adult MSCs from various sources," wrote Y. Zhu and colleagues, Third Military Medical ... Biomedical Engineering, Biomedicine, Biotechnology, Regenerative Medicine, Stem Cell Research, Tissue Engineering, Third Military Medical University. This ...
2009 SEP 21 ... the crucial role of the local cellular environment in fate decision of primary NG2(+) multipotent neural progenitor cells, which may affect their behaviour after transplantation into the ... choice of neural progenitor cells could be dictated by local cellular environment of the adult CNS. The aim of our study was to investigate the effect of hippocampal tissue on ... Main St., Malden, MA 02148, USA. Keywords: Poland, Warsaw, Life Sciences, StemCell Research, Progenitor Cell, Fluorescein, Contrast Media, Cell Proliferation. ...
2009 SEP 21 ... transporter (where ABC is ATP-binding cassette). In the adult pancreas, although various multipotent progenitors have been proposed, the ABCG2 marker has only been detected in the so-called ... "Numerous studies conducted in a diversity of adult tissues have shown that certain stem cells are characterized by the expression of a protein known as the ABCG2 transporter ... has only been detected in the so-called 'side population' (a primitive haematopoietic cell population with a multipotential capacity)," researchers in Barcelona, Spain report. ...
2009 AUG 31 ... cellular events, but evidence for a single miRNA that can efficiently differentiate multipotentstem cells into a specific lineage or regulate direct reprogramming of cells into an ... smooth muscle cells. miR-145 was necessary for myocardin-induced reprogramming of adult fibroblasts into smooth muscle cells and sufficient to induce differentiation of ... into a specific lineage or regulate direct reprogramming of cells into an alternative cell fate has been elusive." "Here we show that miR-145 and miR-143 are ...
2009 OCT 12 ... "Human mesenchymal stem cells (hMSCs) are multipotentstem cells found in the adult bone marrow that have the capacity to differentiate into ... the adult bone marrow that have the capacity to differentiate into various mesenchymal cell types. The hMSCs may provide a potential therapy to restore damaged tissues or organs of ...
2009 AUG 17 ... and the Bowman's capsule. The aim of the present study was to investigate whether multipotentstem cells are present also in the adult human-decapsulated glomeruli and whether they ... cells and a population of CD133(-)CD146(+) cells expressing mesenchymal stem cell (MSC) markers and renal stem cell markers CD24 and Pax-2. The CD133(+)CD146(+) cells ...
2009 AUG 17 ... "Spermatogonial stem cells (SSCs) are a documented source for adultmultipotentstem cells. Thus, the isolation of SSCs is of great interest," investigators in ... is difficult because of their low total numbers and the lack of well-characterized cell surface markers. Glial-cell-derived neurotrophic factor family receptor alpha-1 (GFR ...
2009 NOV 16 ... University of Texas. The researchers concluded: "The results suggest that multipotentstem cells can be expanded ex vivo and can contribute meaningfully to long-term ... concomitant higher rate of graft-versus-host disease that would be observed between an adult marrow graft and a mismatched host. A disadvantage to the use of UCB for HSCT is that ... Stem Cells, "The use of umbilical cord blood (UCB) grafts for hematopoietic stem cell transplantation (HSCT) is a promising technique that permits a degree of human leukocyte ...
2009 AUG 17 ... "and Objective: Mesenchymal stem cells (MSCs) are multipotent cells present in adult bone marrow that replicate as undifferentiated cells and can ... model system may be useful for exploring the cross-talk between circadian rhythm and cell function.." Kushibiki and colleagues published their study in ...
2009 OCT 12 ... multiple organ systems." "This is because stem cells are pluripotent or multipotent cells that can recapitulate developmental paths to repair damaged tissues. However, it ... needed as 'molecular adjuvants' or enhancers of stem cells administered in therapy or adult stem cells in the diseased tissues. Hence, a combination of stem cell-based, ...
