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2009 SEP 22 ... Airway contractions mediated by the endothelin (ET)(A) receptor, ETB receptor and M-3 muscarinic receptor were augmented, and the augmented contraction was most obvious in lobar ... study was to investigate airway hyperreactivity mediated by contractile and dilative receptors in an ovalbumin (OVA)-induced model of rat asthma." "Asthmatic E3 rats ...
2009 NOV 2 ... modulates the function of medium spiny projection neurons through the activation of muscarinic receptors, increasing the NMDA-induced NSCR. This enhancement is reflected as a change in the ...
2009 NOV 9 ... has a relatively low potency at other receptor sites, such as 5-HT2C, histamine H1, muscarinic, and adrenergic receptor sites, that have been associated with adverse events in some ... cariprazine is an orally active D3/D2 partial agonist with preferential binding to D3 receptors. Additionally, cariprazine has a relatively low potency at other receptor sites, such as ...
2009 SEP 22 ... released Ca2+ from thapsigargin-sensitive intracellular stores only during activation of muscarinic receptors. Agonists with low efficacy for muscarinic receptor-mediated Ca2+ responses facilitated ...
Subject: Pharmacology and Experimental Therapeutics
2009 NOV 9 ... motivation and reward. These diverse cholinergic effects are mediated by nicotinic-and muscarinic-type cholinergic receptors (nAChR and mAChR, respectively)," scientists in the United ...
2009 SEP 29 ... New research, 'Involvement of nicotinic and muscarinic receptors in the endogenous cholinergic modulation of the balance between excitation and ...
2009 NOV 9 ... Data detailed in 'Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia' have been presented. According to ...
2009 NOV 9 ... Data detailed in 'Role of M2, M3, and M4 muscarinic receptor subtypes in the spinal cholinergic control of nociception revealed using siRNA ... revealed using siRNA in rats' have been presented. "Muscarinic acetylcholine receptors (mAChRs) are involved in the control of nociception in the spinal cord. The M(2), M(3), ...
2009 NOV 23 ... effects of exendin-4 were unaffected by systemic pretreatment with the pro-motility muscarinic agonist bethanechol, but were abolished by systemic administration of the nitric oxide ... the United States report. "A high density of GLP-1 containing neurones and receptors are present in brainstem vagal circuits, suggesting that the gastroinhibition may be ...
2009 NOV 2 ... receptors, and the biphasic response was caused by the activation of multiple types of muscarinic receptors. Compared with CAR-inhibited cells, CAR-excited Pf cells showed 1) a decreased membrane ...
2009 NOV 16 ... New research, 'M3 muscarinic acetylcholine receptor is associated with beta-catenin in ventricular myocytes during ... The present study was designed to investigate whether the M(3) muscarinic acetylcholine receptors (mAChR) is associated with beta-catenin in the ventricular myocardium during ischaemic ...
2009 NOV 23 ... blocked the effects of donepezil, indicating involvement of both nicotinic and muscarinic receptors in donepezil's actions," wrote J.R. Das and colleagues, Howard University, Department ...
2009 NOV 2 ... "Xiao Z, Deng PY, Yang C, Lei S. Modulation of GABAergic transmission by muscarinic receptors in the entorhinal cortex of juvenile rats. J Neurophysiol 102: 659-669, 2009," ...
2009 SEP 22 ... G protein-coupled receptors (GPCRs), evaluating the binding sites of both the M2 muscarinic acetylcholine receptor and the D2 dopamine receptor. Receptors were expressed in Xenopus ...
2009 OCT 5 ... contractility. In the collagen gel contraction assay, carbachol (1 - 10 mc M) and the muscarinic receptor agonist bethanechol (30 - 300 PM) dose-dependently induced IMFs contraction. ... that acetylcholine elicits Ca2+-dependent IMF contraction through muscarinic M-2 and M3 receptors." Iwanaga and colleagues published their study in the Journal of ...
2009 NOV 10 ... cholinergic system promotes higher brain function in part by signaling through the M-1 muscarinic acetylcholine receptor (mAChR). During Alzheimer's disease (AD), these cholinergic ... disease (AD), these cholinergic neurons degenerate, therefore selectively activating M-1 receptors could improve cognitive function in these patients while avoiding unwanted peripheral ...
2009 NOV 16 ... from Harbin, People's Republic of China, "We have studied the association between M-3 muscarinic acetylcholine receptors (M-3-mAChR) and protein kinase C-epsilon (PKC-epsilon) during ...
2009 NOV 9 ... TRPC4 and TRPC6. In intestinal smooth muscle cells TRPC4 and TRPC6 channels are gated by muscarinic receptors and are responsible for MICAT," wrote V.V. Tsvilovskyy and colleagues, University of ...
2009 SEP 21 ... (DOI) without affecting the stimulation by mGlu1/5 or muscarinic receptors. The action of LY379268 was prevented by the preferential mGlu2/3 receptor antagonist ...
2009 OCT 6 ... effects of HE on smooth muscle contraction and on pharmacologically relevant (muscarinic, 1,4-DHP and purinergic) receptors in the rat bladder." "Additionally, ...
