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2009 JUL 20 ... of EPO. EPO treatment increased nNOS expression in isolated neonatal mouse ventricular myocytes. Cotreatment with the phosphatidylinositol 3 (PI3)-kinase inhibitor, LY294002 [ ... suggesting that EPO regulates nNOS expression via PI3-kinase and Akt. To examine the in vivo antiarrhythmic effects of EPO, wild-type (WT) and nNOS(-/-) mice were anesthetized and, ...
2009 SEP 14 ... p110 alpha (also known as Pik3ca), but not p110 beta (also known as Pik3cb), in cardiac myocytes of adult mice reduced I-Ca,I-L and blocked insulin signaling in the heart. p110 ... of LTCCs on the cell surface and a contractile defect that decreased cardiac function in vivo. Similarly, pharmacological inhibition of p110 alpha decreased I-Ca,I-L and ...
2009 SEP 21 ... clarified. Reexpression of low voltage-activated T-type calcium channels in ventricular myocytes together with other fetal genes during cardiac pathologies could confer automaticity to ... to these cells and would represent a proarrhythmogenic condition if occurring in vivo," scientists writing in the journal Endocrinology report. "In the present ...
2009 NOV 16 ... to analyze the modulation of the mTOR pathway and proliferative activity of the uterine myocytes by estradiol alone and in combination with the mTOR-specific inhibitor rapamycin. Our ... rats," wrote S. Jaffer and colleagues. The researchers concluded: "Our in vivo data demonstrate that estradiol was able to activate the PI3K/mTOR signaling pathway in ...
2009 JUL 27 ... DR, Sam F. Fenofibrate inhibits aldosterone-induced apoptosis in adult rat ventricular myocytes via stress-activated kinase-dependent mechanisms. Am J Physiol Heart Circ Physiol 296: ... in Bax, p53, and cleaved caspase-3 and decreases in Bcl-2 protein expression in ARVM. In vivo studies demonstrated that chronic fenofibrate (100 mg.kg body wt(-1).day(-1)) inhibited ...
2009 OCT 5 ... direct inotropic and p38 MAP kinase signaling effects of HIV gp120 on isolated cardiac myocytes in vitro. We now report effects of a single injection of HIV gp120 on cardiac ... We now report effects of a single injection of HIV gp120 on cardiac hemodynamics in vivo. HIV gp120 (50 mu g/kg) was injected intravenously and hemodynamics assessed at 1, 24, ...
2009 NOV 9 ... hypoxia/reoxygenation-induced apoptosis of isolated cardiomyocytes. Isolated rat cardiac myocytes were pretreated with rosiglitazone or vehicle for 30 min before they were subjected to ... size and improve myocardial function during ischemia/reperfusion in animal studies in vivo. However, the mechanism of this effect is unclear, and it is open if PPAR-gamma agonists ...
2009 NOV 16 ... with myeloperoxidase (immunostaining, neutrophil marker) but appeared in cardiac myocytes. The study of isolated cardiac myocytes revealed the cytokine stimulates ROS which ... which elicit production of angiogenic factors. Apocynin inhibited G-CSF effects both in vivo and in vitro," wrote A.C.R. Carrao and colleagues, Ohio University, Medical Department. ...
2009 AUG 17 ... of China report. "We tested this hypothesis using primary cultured cardiac myocytes and fibroblasts and one well-established animal model of cardiac hypertrophy. The ... and heart failure. Because crocetin represses oxidative stress in vitro and in vivo, we have suggested that crocetin would repress cardiac hypertrophy by targeting ...
2009 NOV 23 ... into mesoderm-type cells such as osteoblasts, chondrocytes, adipocytes and myocytes. Together the multipotent nature of MSCs and the facility to expand them in vitro make ... in vitro osteogenic differentiation of MSCs, a rapid and simple model to evaluate in vivo tissue formation is still lacking. Here, we describe the unique capacity of the murine ...
2009 JUL 20 ... deposition, diastolic dysfunction and cardiac hypertrophy. In addition, ventricular myocytes isolated from the aldosterone-treated group showed increased I-CaL density and ... Experimental Physiology report. "The aim of this study was to analyse exvivo the electrophysiological characteristics of the L-type cardiac calcium current ...
2009 NOV 1 ... pathway. Here we investigated the role of Nampt in mediating NAD(+) synthesis in cardiac myocytes and the function of Nampt in the heart in vivo. Expression of Nampt in the heart was ...
2009 SEP 28 ... heart are concurrent with changes in the size, shape, and cytoskeleton of ventricular myocytes," scientists in the United States report. "In this study, we asked how ... myocytes cultured on rectangles of aspect ratios approaching those observed in vivo had a uniaxial orientation of their myofibrils. Using confocal and atomic force ...
2009 SEP 14 ... with pheochromocytoma-conditioned media exhibited greater cytoskeletal changes than myocytes cultured with identical doses of NE alone, including more profound dose-dependent ... encapsulation system to control PC12 cell kinetics and NE release in vitro and in vivo. Primary neonatal rat cardiomyocytes incubated with pheochromocytoma-conditioned media ...
2009 OCT 19 ... by cAMP) in the regulation of the contractile properties of rat ventricular cardiac myocytes." "We report that both PKA and Epac increased cardiac sarcomere ... in permeabilized cardiomyocytes. Moreover, ventricular myocytes, which were infected in vivo with a constitutively active form of Epac, showed enhanced myofilament Ca2+ sensitivity ...
2009 SEP 28 ... (non-Ind) hearts. There was no cellular hypertrophy since WT, non-Ind, and Ind myocytes had similar whole cell membrane capacitance. In Ind myocytes, NCX1 current amplitude was ... stroke volume, and cardiac output were similar among the three groups of animals. In vivo close-chest catheterization demonstrated similar contractility and relaxation among the ...
2009 OCT 5 ... full-length protein). Inhibition of nonsense-mediated mRNA decay in cultured cardiac myocytes or in vivo with emetine or cycloheximide increased the level of nonsense mRNAs ...
2009 NOV 23 ... "Trabeculae carneae are the smallest naturally arising collections of linearly arranged myocytes in the heart. They are the preparation of choice for studies of function of intact ... myocardium in vitro," scientists in Auckland, New Zealand report. "In vivo, trabeculae are unique in receiving oxygen from two independent sources: the coronary ...
2009 NOV 9 ... mI(CAT) channel activity independent of other channel subunits. In TRPC4-deficient ileal myocytes the carbachol-induced membrane depolarizations are diminished greatly and the ... deficient mice and analyzed them for intestinal smooth muscle function in vitro and in vivo. In intestinal smooth Muscle cells TRPC4 forms a 55 pS cation channel and underlies more ...
