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2009 FEB 9 ... lethality, indicating that the, are partially functionally redundant. Bristle defects in myt1 mutant adult flies prompted a phenotypic revealed cell-cycle defects, ectopic apoptosis, and ...
2009 MAY 4 ... HT1197). Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to CDK1 activation in T24 ... of the cell cycle arrest. In contrast, flavokawain A induced a G(2)-M arrest in six p53 mutant-type, high-grade bladder cancer cell lines (T24, UMUC3, TCCSUP, 5637, HT1376, and ...
2005 DEC 26 ... cycle regulator during gametogenesis. Notably, more proliferating cells were observed in myt1 mutant testes and ovaries than controls."
"This can partly be attributed to ...
2008 MAR 17 ... "Myelin transcription factor 1 (Myt1) is one of the three vertebrate C2HC-type zinc finger transcription factors that include ... hormone levels were normal. We also created pancreas-specific Myt1 knockout mice. These mutant animals had no obvious physical defects from their wild-type littermates. Male mutant ...
2008 AUG 11 ... in pancreatic progenitors. Vice versa, Ngn3 protein production induces the expression of Myt1. Furthermore, pancreatic Myt1 expression largely, but not totally, relies on Ngn3 ... pancreatic cells express glucagon and other a cell markers in Ngn3 nullizygous mutant animals. These results demonstrate that Myt1b and Ngn3 positively regulate each other's ...
2008 NOV 25 ... Cdc25 -> CDK1; CDK1 -vertical bar Wee1 -vertical bar CDK1; and CDK1 -vertical bar Myt1 -vertical bar CDK1) that collectively function as a bistable trigger."
... could render it dispensable. Our approach was to express the phosphorylation site mutant CDK1AF, which short-circuits the feedback loops, in HeLa cells, and to monitor cell ...
2007 SEP 10 ... by G(2) arrest; up-regulation of tumor necrosis factor (TNF), SPHK1, STAT5A, p21, MYT1, and SSTR3; and down-regulation of SPP1, CDC25 phosphatases, and of genes involved in ... Germany report.
"In diffuse-type gastric cancer, 10% of patients express mutant d9-E-cadherin on the surface of tumor cells that is targeted by the monoclonal antibody ...
2006 OCT 31 ... cycle regulator during gametogenesis. Notably, more proliferating cells were observed in myt1 mutant testes and ovaries than controls."
"This can partly be attributed to ...
2007 NOV 19 ... by G(2) arrest; up-regulation of tumor necrosis factor (TNF), SPHK1, STAM, p21, MYT1, and SSTR3; and down-regulation of SPP1, CDC25 phosphatases, and of genes involved in ... Germany report.
"In diffuse-type gastric cancer, 10% of patients express mutant d9-E-cadherin on the surface of tumor cells that is targeted by the monoclonal antibody ...
2006 MAY 30 ... cycle regulator during gametogenesis. Notably, more proliferating cells were observed in myt1 mutant testes and ovaries than controls."
"This can partly be attributed to ...
