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2009 JUL 27 ... stem cells begin to differentiate into different terminal cell types (e.g. heart, blood, neural cells, etc.), the marker allows researchers to identify and select a particular cell ...
2009 JUN 29 ... "Studies have documented the proliferative effects of epidermal growth factor (EGF) on neural progenitor cells in the normal or injured brain. The effect of EGF on post-stroke ... Pharmacology, Physiology, Progenitor Cell, Renovascular Hypertension, Serum albumin, StemCell Research, Therapies.
This article was prepared by Biotech Business ... or injured brain. The effect of EGF on post-stroke cerebral expression of nestin, a marker of neural progenitor cells, has not been examined in hypertensive rats," investigators ...
2009 SEP 7 ... encodes an RNA binding protein, which is likely to be associated with self-renewal of neural, intestinal and mammary progenitor cells and is believed to influence the Notch ... involved multipotent cells, but no specific molecular markers for mammary epithelial stem cells were revealed. These studies principally concerned human and mouse mammary tissue, ... 1 gene expression showed a strong correlation with that of Ki-67, that is a marker of cell proliferation," wrote M. Colitti and colleagues, University of Udine. The ...
2009 NOV 16 ... cells having stemcell-like qualities are widely employed models for the study of neuralstem/progenitor cell proliferation and differentiation. We find that human BE(2) C ... (Cdk-interacting protein 1) and cell cycle arrest, induction of the neuroblastic marker doublecortin and of the neuron-specific intermediate filament protein, peripherin, and ...
2009 SEP 14 ... Data detailed in 'Cell surface N-glycans mediated isolation of mouse neuralstem cells' have been presented. According to a study from Tokyo, Japan, "The ... "These results indicate that complex type N-glycans is a valuable cell surface marker for living mouse NSCs from both the embryonic and adult brain." Hamanoue ...
2009 JUL 6 ... of hESC aggregates into columnar neuroectodermal cells and their organization into neural tube-like rosettes as determined morphologically. Immunoblot analyses confirmed the ... According to recent research published in the journal Stem Cells and Development, "The growth factors that drive the division and ... United States, Madison, Chorionic, Chorionic Gonadotropin, Drugs, Embryonic Stem Cell Research, Estradiol, Gonadotropin, Hormones, Mifepristone, Neurology, Opioid Receptors, ... role of these hormones; both antagonists inhibited nestin expression, an early marker of neural precursor cells normally detected during rosette formation. Conversely, ...
2009 OCT 19 ... "Human fetal neuralstem/progenitor cells (hNSCs) are investigated for their potential as a cell source for ... peduncle) brain regions. The majority of migratory cells expressed the stem cell marker, nestin. A fraction of grafted cells acquired a neuronal phenotype expressing ...
2009 OCT 12 ... angiopoietin 2 (ANG2), a proangiogenic gene, expression in subventricular zone neural progenitor cells. Incubation of neural progenitor cells with recombinant human ANG2 ... Biological Chemistry, Biotechnology, Gene Therapy, Neurogenesis, Progenitor Cell, StemCell Research, Henry Ford Hospital. This article was prepared by Pain & ... human ANG2 significantly increased the number of beta-III tubulin-positive cells, a marker of immature neurons, but did not alter the number of glial fibrillary acidic protein ...
2009 NOV 23 ... in neuroblastoma, and hypoxia dedifferentiates cultured neuroblastoma cells toward a neural crest-like phenotype. Here, we identify HIF-2 alpha as a marker of normoxic neural ... HIF-2 alpha as a marker of normoxic neural crest-like neuroblastoma tumor-initiating/stem cells (TICs) isolated from patient bone marrows," scientists in Malmo, Sweden report. ... sympathetic neuronal differentiation when these TICs were grown in vitro under stem cell-promoting conditions. Xenograft tumors of HIF-2 alpha-silenced cells were widely ...
2009 NOV 2 ... used to ablate the retinal pigment epithelial (RPE) layer in C57B16 mice and initiate neural retinal degeneration," investigators in the United States report. "HSCs ... "The ability to control the differentiation of adult hematopoietic stem cells (HSCs) would promote development of new cell-based therapies to treat multiple ... RPE layer, with typical RPE phenotype including coexpression of another RPE-specific marker, CRALBP, and photoreceptor outer segment phagocytosis. Retinal degeneration was ...
2009 AUG 10 ... are presented in the report 'Focal laser-lesions activate an endogenous population of neuralstem/progenitor cells in the adult visual cortex.' According to a study from Bochum, ... Fresh data on stem cell research are presented in the report 'Focal laser-lesions activate an endogenous ... matter within the lesion penumbra. The cells expressed the neural stem/progenitor cell marker Nestin and the 473HD-epitope. Tissue prepared from the lesion area by micro-dissection ...
2009 JUL 20 ... in other parts of the brain than telencephalon. To understand common characteristics of neuralstemcell niches in vertebrates, we studied the origin and architecture of a previously ... of a previously unknown stem cell niche using transgenic lines, in vivo imaging, and marker analysis. We show that bipotent stem cells are maintained in a distinct niche in the ...
2009 JUN 22 ... "Neuralstem cells (NSC) are progenitors that can give rise to all neural lineages. They are ... Weinheim, Germany.
Keywords: United States, Biotechnology, Embryonic Stem Cell Research, Proteomics, Pennsylvania State University, Medical Department.
... "These cells express the intermediate filament nestin, commonly considered an NSC marker. NSC can be derived as neurospheres from human embryonic stem cells (hESC). The ...
2009 JUL 6 ... Immunohistochemical analyses revealed that the tumor was strongly positive for not only neural markers but also a glial marker, while the MT was positive for a neuralmarker. The ... index was 9.1% in the tumor body and 0% in the MT. Musashi 1, a marker of neural stem cells, was strongly positive in both the tumor body and the MT. We speculate that the ... 3311 Gz Dordrecht, Netherlands. Keywords: Japan, Gifu, Life Sciences, Stem Cell Research, Oncology, Pathology, Gifu University, Medical Department. This ...
2009 JUL 27 ... cell culture. These were then subjected to immunocytochemistry for specific markers of neuralstem cells (nestin) and penile smooth muscle cells, i.e. alpha-smooth muscle actin ... exposed to N2 media continued to maintain the characteristic morphological and protein marker features of FBSCs, while the cells exposed to the conditioned media acquired the ...
2009 SEP 29 ... is essential for embryogenesis and tumor suppression. Drosophila neural progenitors (neuroblasts) align their spindle along an apical/basal polarity axis to ... "Precise regulation of stemcell self-renewal/differentiation is essential for embryogenesis and tumor suppression. ... spindle orientation over multiple divisions within intact brains, followed by molecular marker analysis of cell fate. We find that spindle alignment orthogonal to apical/basal ...
2009 AUG 31 ... [alpha-smooth muscle actin, glial fibrillary acidic protein (GFAP), neurotrophin 3 and neural-cell adhesion molecule], markers of LPCs (keratin 7 and keratin 19) and a proliferation ... of the liver progenitor cell niche in different types of liver disease,' new data in stem cell research. "When hepatocyte replication during liver disease is insufficient for ... adhesion molecule], markers of LPCs (keratin 7 and keratin 19) and a proliferation marker (Ki67) were used. A very relevant spontaneous model to evaluate LPC niche activation in ...
2009 OCT 12 ... cultured in DhAM extract had a high survival rate (> 80%). Moreover, the cortical neural axons in the experimental group (BMSC + DhAM) were longer (287.37 +/- 12.72 mu m) than ... Central Nervous System Disease, Central Nervous System Injury, Microscopy, Neurology, StemCell Research, Transplantation, Medical College. This article was prepared ... the lengths of axons in each group were studied using the positive axon-specific marker NF-H. The DhAM was devoid of cellular components and only its intact basement membrane ...
2009 NOV 16 ... (IL-1) plays a pivotal role in terminal dopaminergic differentiation of midbrain-derived neural precursor cells already committed to the mesencephalic dopaminergic phenotype (named ... mdNPCs by IL-1 beta depends on activation of the ERK1/2 and p38 MAP kinase pathway. STEM CELLS 2009;27:2009-2021." Sabolek and colleagues published their study in ... USA. Keywords: Germany, Dresden, Enzymes, Hydroxylase, Kinase, Stem Cell Research, Technical University of Dresden. This article was prepared by ... Nurr1 and Pitx3, and a subsequent increase of tyrosine hydroxylase protein as an early marker for dopaminergic neurons in vitro. These effects of IL-1 beta were specific for mdNPCs ...
2009 OCT 19 ... suppressed hESC proliferation and promoted nestin expression, an early marker of neural precursor cell (NPC) formation. The induction of NPC differentiation via the ... normally associated with neurodegenerative conditions, is expressed by human embryonic stem cells (hESCs)," scientists in the United States report. "We now report ...
