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2009 OCT 19 ... The bICP0 gene also contains a novel early promoter that was activated by DEX in mouse neuroblastoma cells. Expression of a cellular transcription factor, C/EBP-alpha, was stimulated by ... Keywords: United States, Lincoln, Dexamethasone, Drugs, Herpesvirus, Pharmaceuticals, Therapy, Treatment, Virology, University of Nebraska. This article was prepared by ...
2009 AUG 17 ... In the present study, we showed that a peripheral membrane protein encoded by the neuroblastoma-amplified gene (NAG) is a subunit of the syntaxin 18 complex," scientists writing in ... Ethylmaleimide, Neuroblastoma, Oncology, Pharmaceuticals, Protein Encoding, Proteomics, Therapy, Treatment, Tokyo University. This article was prepared by Pain & Central ...
2009 NOV 9 ... here the expression profile of miRNAs during neuronal differentiation in the human neuroblastoma cell line SH-SY5Y. Six miRNAs were significantly upregulated during differentiation ... "MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression at the posttranscriptional level. Research on miRNAs has highlighted their ... Keywords: United States, Cambridge, Life Sciences, Hematology, Oncology, Neuroblastoma, Therapy, Treatment, Retinoic Acid, Cellular. This article was prepared by Pain & ...
2009 NOV 9 ... nucleus and attenuated the formation P-CREB." "SH-SY5Y cells, a human neuroblastoma cell line, were cultured. Cells were depolarized with KCl and the phosphorylation of ... monophosphate response element-binding protein (CREB) (P-CREB) are necessary for new gene expression and have been linked to long-term potentiation, a process important in memory ... Oncology, Neuroblastoma, Pain Medicine, Anesthesia, Isoflurane, Pharmaceuticals, Drugs, Therapy, Treatment, Adenosine, Adenosine monophosphate, Dietary Supplement, Micronutrient, New ...
2009 AUG 17 ... A report, 'Mdm2 deficiency suppresses MYCN-Driven neuroblastoma tumorigenesis in vivo,' is newly published data in Neoplasia. "Neuroblastoma is ... remarkable p53 stabilization counter-balanced by epigenetic silencing of the p19(Arf) gene in the Mdm2 haploinsufficient tumors. In human neuroblastoma xenograft models, ... contact Z. Chen, Texas Children's Cancer Center and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030 USA.. Publisher contact ...
2009 AUG 10 ... with V alpha 24-invariant NKT cells (NKTs) associates with favorable outcome in neuroblastoma and other cancers. Although NKTs can be directly cytotoxic against CD1d(+) cells, the ... produced IL-6 in primary tumors and in the BM of patients with metastatic neuroblastoma. Gene expression analysis using TaqMan low-density arrays of 129 primary human neuroblastomas ... 300, Ann Arbor, MI 48103, USA. Keywords: United States, Houston, Anticancer Therapy, Antitumor Activity, Biotechnology, Cancer, Hematology, Neuroblastoma, Oncology, Severe ...
2009 OCT 12 ... from the United States, "Radioadaptive response/NF kappa B/Fractionated irradiation/Neuroblastoma/Transcriptional responses after FIR. Radiotherapy has been used as an adjunctive ... (10 Gy) radiation (SDR) and FIR (2 Gy x 5) in human neuroblastoma cells. Alterations in gene expression were analyzed using QPCR-profiling, NF kappa B activity using electrophoretic ... radiation (FIR) modulated molecular targets is imperative in targeted molecular therapy. Accordingly, we investigated the (i) expression of genes representing six functional ...
2009 OCT 5 ... has been closely linked to poor treatment response in several cancers, most notably neuroblastoma. Homozygous deletion of the MRP1 gene in primary murine neuroblastoma tumors resulted in ... Acid, Doxorubicin Hydrochloride, Drug Development, Drug Resistance, Drug Therapy, Drugs, Etoposide, Hematology, Neuroblastoma, Oncology, Pharmaceuticals, Proteomics, ...
2009 OCT 19 ... States, "In this report, we reveal that etoposide inhibits the proliferation of SK-N-AS neuroblastoma cancer cells and promotes protein kinase C delta (PKC delta)- and caspase-dependent ... Apoptosis, Biotechnology, Cancer, Caspase, Drugs, Enzyme Research, Etoposide, GeneTherapy, Hematology, Kinase, Molecular Pharmacology, Molecular Research, Molecular ...
2009 NOV 2 ... Fresh data on neuroblastoma are presented in the report 'Neuroblastoma: biology and staging.' "Neuroblastoma is ... therapy. The varied clinical behavior reflects genetic heterogeneity, with many possible gene candidates identified in studies using comparative genetic hybridization arrays, RNA ...
2009 OCT 19 ... "We have recently demonstrated that fibroblast growth factor (FGF)-2 promotes neuroblastoma cell differentiation and overrides their mitogenic response to IGF-I. However, the ... cell sorting analysis indicated that FGF-2 promotes G1/G0 cell cycle phase arrest. Gene expression by RT2-PCR and cellular localization showed up-regulation of p21. We then ... Keywords: Australia, Parkville, Biotechnology, Cell Differentiation, Endocrinology, Gene Therapy, Hematology, IGF I, Neuroblastoma, Oncology, RNA Research, Tissue Engineering, ...
2009 NOV 2 ... of saposin C coupled with dioleoylphosphatidylserine in preclinical cancer models. Neuroblastoma, malignant peripheral nerve sheath tumor and, breast cancer cells were treated with ... Cancer Research, Caspase, Clinical Trials, Enzyme Research, Experimental Design, GeneTherapy, Hematology, Neoplasms, Nerve Sheath Tumors, Neuroblastoma, Oncology, Pre-Trials ...
2009 AUG 17 ... fibril formation less effectively than dimers, which also protected cultured neuroblastoma cells from A beta neurotoxicity," wrote E. Podoly and colleagues, Hebrew University. ... Disease, Biological Chemistry, Biotechnology, Butyrylcholinesterase, Enzyme Research, GeneTherapy, Pathology, Synthetic Peptides, Hebrew University. This article was ...
2009 SEP 21 ... of endogenous neuroglobin (Ngb) in neuronal cells under oxidative stress. A stable N2a neuroblastoma cell line expressing the Ngb-siRNA plasmid (N2a/Ngb-siRNA) was established by neomycin ... "Reverse transcription (RT)-PCR and Western blot analysis were used to detect Ngb gene and protein levels. Hydrogen peroxide was used to induce oxidative stress in N2a cells. ... of China, Wuhan, Life Sciences, Hematology, Oncology, Neuroblastoma, Biotechnology, Gene Therapy, Enzyme Research, Dehydrogenase, Neomycin Sulfate, Pharmaceuticals, Drugs, Treatment. ...
2009 OCT 12 ... report. "Here we present evidence that CDK2 is synthetically lethal to neuroblastoma cells with MYCN amplification and overexpression. Neuroblastomas are childhood tumors ... genes have a synthetically lethal relationship when the silencing or inhibiting of 1 gene is only lethal in the context of a mutation or activation of the second gene. This ... of the tumors have MYCN amplification, and these tumors are ultimately refractory to any therapy. Targeted silencing of CDK2 by 3 RNA interference techniques induced apoptosis in ...
2009 AUG 17 ... gene expression by AhR. N2a-R beta cells were established by transfecting murine neuroblastoma Neuro2a with the rat AhR cDNA. TH expression induced by TCDD was assessed by RT-PCR and ... Dopamine Hydrochloride, Drugs, Environmental Health, Enzyme Research, Epidemiology, Gene Therapy, Genetics, Genomics, Hematology, Hydroxylase, Learning Disabilities, Liquid ...
2009 AUG 24 ... 350 Main St., Malden, MA 02148, USA. Keywords: Czech Republic, Prague, Neuroblastoma Gene Therapy, Biotechnology, Cell Signalling, Central Nervous System Disease, Central Nervous System ...
2009 NOV 2 ... population of progenitors (HUCBNP), differentiated toward neuronal phenotype by human neuroblastoma-conditioning medium (CM) and nerve growth factor (NGF), which have been found to confer ... Genetics, Genomics, Hematology, Immunology, Interferon, Interferon Gamma, Leukemia GeneTherapy, Medical Device, Neuroblastoma, Oncology, RNA Research, Stem Cell Research, ...
2009 NOV 2 ... "Overexpression of MTDH/AEG-1 is frequently observed in melanoma, glioma, neuroblastoma, and carcinomas of breast, prostate, liver, and esophagus and is correlated with poor ... have established a functional role of MTDH (Metadherin)/AEG-1 (Astrocyte Elevated Gene 1) in several crucial aspects of tumor progression, including transformation, evasion of ... Esophageal, Gastroenterology, Glioma, Hematology, Melanoma, Neuroblastoma, Oncology, Therapy, Treatment, Princeton University. This article was prepared by Pain & ...
2009 NOV 16 ... tumor affinity (G2-HD-OEI) to target a N/S-expressing plasmid (CMV-NIS-pcDNA3) to neuroblastoma (Neuro2A) cells. Incubation with NIS-containing polyplexes (G2-HD-OEI/NIS) resulted in a ... tumor mouse models following transcriptionally targeted sodium iodide symporter (NIS) gene transfer. These studies showed the high potential of NIS as a novel diagnostic and ... "We recently reported the significant therapeutic efficacy of radioiodine therapy in various tumor mouse models following transcriptionally targeted sodium iodide ...
