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2009 DEC 2 ... of the mechanisms by which the underlying substrate topography can modulate neuronal cell differentiation and migration. We recently demonstrated that plastic nanogratings ...
2009 NOV 30 ... in synaptic plasticity. These processes have been well established as underlying altered neuronal activity and thereby abnormal neuronal circuitry and plasticity, ultimately affecting ... transmission of neurotransmitters, apoptosis and ROS production, all either leading to cell death or playing a role in synaptic plasticity. These processes have been well ...
2009 NOV 30 ... "Apoptosis and oncotic necrosis in neuronal and glial cells have been documented in many neurological diseases. Distinguishing ... in many neurological diseases. Distinguishing between these two major types of cell death in different neurological diseases is needed in order to better reveal the injury ...
2009 NOV 30 ... show that overexpression of sox11 prevented tumorigenesis of NSCL61s by inducing their neuronal differentiation accompanied with decreased levels of plagl1. We also show that ... due to lack of specific markers." "We recently established a mouse glioma cell line, NSCL61, by overexpressing an oncogenic HRas(L61) in p53-deficient neural stem ...
2009 NOV 30 ... potentiation (LTP) of excitatory synapses on these pyramidal neurons and an elevated neuronal excitability in postnatal rat pups after postnatal day 15 (P15). This facilitated LTP ... cortex (mPFC) of postnatal rats that were exposed to cocaine in utero, using whole-cell recording from mPFC layer V pyramidal neurons in acute brain slices." ...
2009 NOV 30 ... to disease pathogenesis remains to be elucidated. We have generated NSC34 motor neuronal cell lines expressing wild-type or mutant SOD1 containing a cleavable IMS targeting signal to ...
2009 NOV 30 ... According to a study from Frankfurt, Germany, "Neuronal death induced by serum deprivation (SD) in HT22-cells was accompanied by a moderate ... such as 3-methyladenine (3-MA) or bafilomycin A1 (BafA1) provided a potentiation of cell death induced by SD. z-VAD and 3-MA in combination were not only ineffective in rescuing ...
2009 DEC 1 ... contribute to the fine-tuning of temporal activation of HOXA cluster genes during neuronal differentiation. Furthermore, elimination of macroH2A2 function in zebrafish embryos ... of both macroH2A variants at many genes encoding key regulators of development and cell fate decisions. On these genes, the presence of macroH2A1+2 is a repressive mark that ...
2009 NOV 30 ... by immunofluorescence and immunogold electron microscopy, both in a fibroblast and a neuronal cell line. Double-labeling showed the pro-vasopressin aggregates to colocalize with the ...
2009 NOV 30 ... and cell polarity genes in immature neural epithelial cells before the specification of neuronal cells," wrote C. Fournierthibault and colleagues, University of Paris. The ...
2009 DEC 2 ... gene family in various species are known to support the survival of numerous neuronal populations, including RGCs, it is less clear whether they are also required for ... The publisher of the American Journal of Human Genetics can be contacted at: Cell Press, 600 Technology Square, 5TH Floor, Cambridge, MA 02139, USA. ...
2009 NOV 30 ... to ER stress-induced pathology, including cultured macrophages, endothelial cells, and neuronal cells subjected to proapoptotic ER stress. Moreover, WT mice subjected to systemic ER ... signaling to downstream apoptotic pathways remain unclear. Using human and mouse cell culture and in vivo mouse models of ER stress-induced apoptosis, we have shown that ...
2009 NOV 30 ... concluded: "This review discusses the new role of mitochondria in regulation of neuronal cell death of neurodegenerative disorders." Naoi and colleagues published their ...
2009 NOV 30 ... signaling in adult-born neurons in vivo exhibit similar defects as DISC1 suppression in neuronal development that can be rescued by pharmacological inhibition of mammalian target of ... information, contact G.L. Ming, Johns Hopkins University, School Medical, Institute Cell Engineering, Baltimore, MD 21205, USA. The publisher of the journal Neuron ...
2009 NOV 30 ... its proprietary HuCNS-SC® product candidate (purified human neural stem cells) for neuronal ceroid lipofuscinosis (NCL), often referred to as Batten disease. On ... "We are encouraged that the agency acknowledges the positive safety profile of the cell dose, surgery, and immunosuppression in our Phase I trial, and that further study is ...
2009 DEC 1 ... in distinguishing between bouts of exploration and exploitation. Nonetheless, the neuronal mechanisms that underlie strategy selection remain poorly understood. We hypothesized ... USA. The publisher of the journal Current Biology can be contacted at: Cell Press, 600 Technology Square, 5TH Floor, Cambridge, MA 02139, USA. ...
2009 DEC 1 ... According to recent research from Vancouver, Canada, "Neuronal morphology plays an essential role in neuronal function. The establishment and ... and function." Lise and colleagues published their study in the Journal of Cell Science (Myosin-Va-interacting protein, RILPL2, controls cell shape and neuronal ...
2009 NOV 30 ... SNc DA neurons. In the dorsal striatum, functional alpha 4* nAChRs were not found on the neuronal somata; however, nicotine acts via alpha 4 beta 2* nAChRs in the DA terminals to ... pathway, chronic nicotine enhancement of alpha 4 beta 2* nAChRs displays selectivity in cell type and in nAChR subtype as well as in cellular compartment. These selective events ...
2009 NOV 30 ... and as an effect of stress. Majority of the BrdU+ cells showed co-labeling with mature neuronal marker NeuN or astrocytic marker S100beta with no further significant effect of either ... were performed once daily for 7 days and neurogenesis analyzed 4 weeks later. BrdU cell counts were significantly reduced as an effect of GR(+/-) genotype and as an effect of ...
2009 NOV 30 ... (Neurons of the Dopaminergic/Calcitonin Gene-Related Peptide A11 Cell Group Modulate Neuronal Firing in the Trigeminocervical Complex: An Electrophysiological and Immunohistochemical ...
