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2009 OCT 19 ... microtubule star (mts), which encodes a catalytic subunit of protein phosphatase 2A (PP2A), as a negative regulator for aPKC signaling. Impairment of mts function causes defects ...
2009 OCT 13 ... "Although two direct effectors of yeast TORC1 have been reported (Tap42, a regulator of PP2A phosphatases and Sch9, an AGC family kinase), the signaling pathways that couple TORC1 ...
2009 OCT 12 ... was observed following treatment with okadaic acid, a phosphatase 1 (PP1) and 2A (PP2A) inhibitor, which was rather intriguing. This study provided evidence that certain ...
2009 OCT 12 ... (2) this decrease is abolished by cell treatment with okadaic acid (to inactivate PP2A) or geldanamycin (to inactivate Hsp90), (3) phosphorylation of Ser129 neither enhances ...
2009 OCT 27 ... concentration must exceed a threshold for the induction of fructan metabolism; hence PP2A inhibition may result in lower sucrose levels than required for this induction. OA also ...
2009 OCT 12 ... investigators in the United States report. "Protein phosphatases such as PP2A and PP1 have been implicated in the regulation of beta-catenin. However, which ...
2009 NOV 3 ... regulating DELLA protein degradation. In addition, blocking DELLA degradation with a PP1/PP2A phosphatase inhibitor in our cell-free assay suggested that degradation of DELLA ...
2009 NOV 9 ... that okadaic acid, an inhibitor of the major PPP family serine/threonine phosphatases PP2A and protein phosphatase 1 (PP1), had cell type-dependent effects on ARexpression." ...
2009 NOV 3 ... prevent precocious dissociation of cohesin from centromeres. Shugoshins associate with PP2A, which is thought to dephosphorylate cohesin and thereby prevent cleavage by separase ...
2009 OCT 19 ... human tumor cells. Its interaction with the B alpha subunit of protein phosphatase 2A (PP2A) is critical for cell killing; however, the effect of E4orf4 binding is not known," ...
2009 NOV 16 ... protein phosphatase 5), in which key residues predicted for inhibitor contact with PP2A (Ser/Thr protein phosphatase 2A) were introduced into PP1 and PP5 using site-directed ...
2009 OCT 26 ... and increased STAT1 nuclear content in PP2Ac-dependent fashion. Depletion of alpha 4, PP2A, or mTOR enhanced the induction of early (i.e. IRF-1) and late (i.e. caspase-1, hiNOS, ...
2009 OCT 12 ... Lenalidomide inhibited phosphatase activity either directly (Cdc25C) or indirectly (PP2A) with corresponding retention of inhibitory phospho-tyrosine residues. Treatment of ...
2009 NOV 17 ... during cell division." "Shugoshin forms a complex with the phosphatase PP2A that has been proposed to dephosphorylate cohesin proteins to prevent premature loss of ...
2009 NOV 2 ... of China, "It is well established that the protein serine/threonine phosphatase 2A (PP2A) plays very important roles in many different cellular processes, including cell ...
2009 NOV 16 ... compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity,' is now available. "The chemopreventative effects of dithiolethione ...
2009 NOV 3 ... not correlate with the downregulation of PKA kinase activity. Nevertheless, we show that PP2A phosphatase activity is essential for driving Maf1 dephosphorylation and its subsequent ...
2009 OCT 19 ... repair.' According to recent research from the United States, "Protein phosphatase 2A (PP2A) functions as a potent tumor suppressor, but its mechanism(s) remains enigmatic. ...
2009 NOV 23 ... time-dependently cleaved. Mechanistic studies have shown that protein phosphatase 2A (PP2A)-activated glycogen synthase kinase (GSK)-3 is essential for this process. Therefore, ...
