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2009 NOV 23 -- According to recent research from Bonn, Germany, "T helper cells secreting interleukin (IL)-17 (Th17 cells) play a crucial role in autoimmune diseases like multiple sclerosis (MS). Th17 differentiation, which is induced by a combination of......
2009 NOV 23 -- According to a study from Paris, France, "Obesity is a state of chronic low-grade inflammation. Limiting white adipose tissue (WAT) expansion and therefore reducing inflammation could be effective in preventing the progression of obesity and the......
2009 NOV 23 -- "Molecular disruption of the lipid carrier AFABP/aP2 in mice results in improved insulin sensitivity and protection from atherosclerosis. Because small molecule inhibitors may be efficacious in defining the mechanism(s) of AFABP/aP2 action, a......
2009 NOV 23 ... obese adipose secretory proteins that are responsive to the thiazolidinediones class of PPAR-gamma agonizts," investigators in the United States report. "We first showed ...
2009 NOV 23 -- "Loss of bone mass with advancing age in mice is because of decreased osteoblast number and is associated with increased oxidative stress and decreased canonical Wnt signaling. However, the underlying mechanisms are poorly understood,"......
2009 NOV 27 -- "Adiponectin is an adipokine secreted by differentiated adipocytes. Clinical studies suggest a negative correlation between oxidative stress and adiponectin levels in patients with metabolic syndrome or cardiovascular disease," investigators in......
2009 NOV 23 -- "Adipogenesis is a key differentiation process relevant to obesity and associated diseases such as type 2 diabetes. This process involves temporally regulated genes controlled by a set of transcription factors, CCAAT/enhancer-binding proteins......
2009 NOV 16 -- "Induced pluripotent stem (iPS) cells, which are generated from somatic cells by transducing four genes, are expected to have broad application to regenerative medicine. Although establishment of an efficient gene transfer system for iPS cells......
2009 NOV 16 -- According to a study from London, the United Kingdom, "Peroxisome proliferator-activated receptor beta/delta (PPAR beta/delta) is a nuclear receptor found in platelets. PPAR beta/delta agonists acutely inhibit platelet function within a few......
2009 NOV 26 ... IL-6 and TNF-alpha. Tart cherry diet also increased retroperitoneal fat PPAR-alpha and PPAR-gamma mRNA (P=.12), decreased IL-6 and TNF-alpha mRNA, and decreased nuclear factor kappa B ...
2009 NOV 25 -- According to a study from Budapest, Hungary, "The nuclear receptors CAR (constitutive androstane receptor) and PXR (pregnane X receptor) mediate the effects of phenobarbital on gene transcription. To investigate the relative contribution of......
2009 NOV 16 -- "The fatty acid ethanolamides are a class of signaling lipids that include agonists at cannabinoid and alpha type peroxisome proliferator-activated receptors (PPAR alpha). In the brain, these compounds are primarily hydrolyzed by the......
2009 NOV 23 -- According to recent research published in the journal Cardiovascular Diabetology, "Type 2 diabetes mellitus (T2DM) is commonly associated with both microvascular and macrovascular complications and a strong correlation exists between glycaemic......
2009 NOV 23 -- "The global epidemic of metabolic syndrome and its complications demands rapid evaluation of new and accessible interventions. Insulin resistance is the central biochemical disturbance in the metabolic syndrome," investigators in London, Canada......
2009 NOV 23 -- "Fenofibrate is a synthetic ligand for the nuclear receptor peroxisome proliferator-activated receptor (PPAR) alpha and has been widely used in the treatment of metabolic disorders, especially hyperlipemia, due to its lipid-lowering effect. The......
2009 NOV 16 -- "Alcoholic steatosis is a fundamental metabolic disorder in die progression of alcoholic liver disease. Zinc deficiency is one of the most consistently observed biochemical/nutritional manifestations of alcoholic liver disease," investigators......
2009 NOV 17 -- "Fibroblast growth factor 21 (FGF21) is a key metabolic regulator. Expressed primarily in liver and adipose tissue, FGF21 is induced via peroxisome proliferator-activated receptor (PPAR) pathways during states requiring increased fatty acid......
2009 NOV 23 -- "Thiazolidinediones, peroxisome proliferators-activated receptor gamma (PPAR gamma) ligands, have been recognized as a potential therapeutic agents for the treatment of pathological neovascularization. In the present study, we examined the......
