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2009 NOV 23 ... finding that enterocytes of the duodenal epithelium are capable of expressing luminal pancreatic amylase suggests that taste cells of the gustatory epithelium might, in the same way, ...
2009 NOV 23 ... in the United States report. "Increased autophagy was present in pancreatic islets from Pdx1(+/-) mice with reduced insulin secretion and beta cell mass. Pdx1 ...
2009 NOV 23 ... ratios and splenic regulatory T-cell frequencies) and physiological (increase in the pancreatic beta-cell area, attenuation of pancreatic inflammation) benefits," wrote M.J. Parker and ...
2009 NOV 23 ... "Pancreatic beta-cells exposed to high glucose concentrations display altered gene expression, ... survival and growth that may contribute to the slow deterioration of the functional beta-cell mass in type 2 diabetes. These glucotoxic alterations may result from various types of ...
2009 NOV 23 ... 30% of currently marketed drugs. Over the last few years, a number of GPCRs expressed in pancreatic beta-cells and activated by lipids have been discovered." "GPR40 was ... Finally, GPR41 and GPR43 are receptors for short-chain FAs and may indirectly regulate beta-cell function via adipokine secretion," wrote M.A. Kebede and colleagues. The ...
2009 NOV 23 ... the journal Diabetes Obesity & Metabolism, "It is well known that zinc is required in pancreatic beta-cells in the process of insulin biosynthesis and the maturation of insulin ...
2009 NOV 23 ... "Noninvasive determination of pancreatic beta-cell mass in vivo has been hampered by the lack of suitable beta-cell-specific imaging ...
2009 NOV 23 ... been developed as new antidiabetic drugs. These drugs all act through cAMP signalling in pancreatic beta-cells. Until recently, cAMP was generally thought to potentiate insulin secretion ...
2009 NOV 23 ... brain was commonly believed to be insensitive to the effects of this hormone secreted by pancreatic beta cells. However, since the discovery some 30 years ago that insulin receptors are ...
2009 NOV 23 ... duodenal homeobox 1 (Pdx1) is a transcription factor that plays a central role in pancreatic beta-cell function and survival. Complete deficiency of Pdx1 is associated with pancreatic ...
2009 NOV 23 ... comes from laser capture microdissection (LCM), which obtains beta-cell-rich tissue from pancreatic frozen sections. Valuable data can be obtained from animal models, but the real goal is ...
2009 NOV 23 ... published their study in Brazilian Journal of Medical and Biological Research (Reduced pancreatic beta-cell mass is associated with decreased FoxO1 and Erk1/2 protein phosphorylation in ...
2009 NOV 23 ... report. "In this regard, the most effective procedures are bilio-pancreatic diversion (BPD) and duodenal switch procedure curing 98.9% of the diabetes patients, ... study in Diabetes Obesity & Metabolism (Bariatric surgery: unstressing or boosting the beta-cell? Diabetes Obesity & Metabolism, 2009;11(Suppl. 4):130-142). Additional ...
2009 NOV 23 ... and specifically on the notion that insulin and growth factor signalling via Foxo1 in pancreatic beta-cells links insulin secretion with cellular proliferation and survival." ... According to recent research from the United States, "We review mechanisms of beta-cell failure in type 2 diabetes. A wealth of information indicates that it is caused by ...
2009 NOV 23 ... approaches and transgenic models have been engineered to trigger specifically pancreatic injury and thus explore regeneration," investigators in Geneva, Switzerland report. ... "To unravel the cellular and molecular mechanisms involved in beta-cell renewal and expansion throughout life, several different experimental models were ...
2009 NOV 23 ... mellitus, by outlining the contribution of these small RNA molecules in the control of pancreatic beta-cell functions and by reviewing recent studies reporting changes in microRNA expression in ...
2009 NOV 23 ... published in the journal Diabetes, "We showed that 17 beta-estradiol (E-2) favors pancreatic beta-cell survival via the estrogen receptor-alpha (ER alpha) in mice. E-2 activates nuclear ...
2009 NOV 23 ... According to a study from Dresden, Germany, "Pancreatic beta-cells are the sole source of insulin, the major hormonal regulator of glycaemia. In ... recent advances concerning the factors and pathways that enhance ISG biogenesis and beta-cell replication, and propose the existence of 'switch factors' that play a key role in ...
2009 NOV 23 ... Eph receptors and ephrin ligands, as well as extracellular matrix proteins, modulate pancreatic islet function." Jain and colleagues published their study in Diabetes ...
2009 NOV 24 ... regulator. Menin controls proliferation and apoptosis of cells, especially pancreatic beta cells." "We have found that menin contains two functional nuclear ... of beta-catenin in Men1-null mouse embryonic fibroblasts and insulinoma tissues from beta-cell-specific Men1 knockout mice. It is reported that the deregulation of Wnt/beta-catenin ...
