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2009 NOV 29 ... into the mosquito genome which caused the mosquito to express a Plasmodium-repelling peptide. But spreading these genes into wild populations of mosquitoes has proven challenging. ... malaria because different tactics will work in different scenarios. In some places, a vaccine may work best, in more remote places, other low cost, low tech approaches will work ...
2009 NOV 23 ... arthritis and most recently, H1N1 influenza, the scientists' studies show that LEAPS peptide immunogens can convert precursor cells from mouse or humans to become dendritic cells ... in collaboration with scientists at the Cleveland Clinic and CEL-SCI on CEL-SCI's LEAPS vaccine technology. The data was presented at the 7th GTCbio Vaccine: "All Things Considered" ...
2009 NOV 23 ... whether multiple HIV-1-specific T-cell functions are enhanced by stimulation with HIV-1 peptide-loaded DC derived from HIV-1-infected subjects on antiretroviral therapy. We first found ... particularly dendritic cells (DC)," scientists writing in the journal Clinical and Vaccine Immunology report. "Here we examined whether multiple HIV-1-specific ...
2009 NOV 23 ... monocytogenes (Lm Delta actA Delta inlB) as a vaccine vector. We present data that peptide-specific T cells recognize the human monocytic cell line THP-1 infected with recombinant ...
2009 NOV 23 ... than LPS-untreated LLO 91-99-loaded BM-DC (LLO DC). Using tetrameric H2-K-d/LLO 91-99 peptide complex, specific CD8(+) T cells were found in MLN as well as the spleen in LPS-LLO ... CTL responses in the lung. Our objective was to develop an efficacious mucosal DC vaccine to generate protective CTL against respiratory infections with intracellular pathogens. ...
2009 NOV 16 ... The current application uses virus-like particles as a support to present CCR5 peptide antigens," scientists in Skien, Norway report. "The virus-like particle ... (VLP)-CCR5 composition aims to function as either a preventative and/or therapeutic vaccine inducing durable autoantibodies that can block CCR5 and prevent HIV entry or attenuate ...
2009 NOV 23 ... the H37Rv induced by Hsp16.3 protein were compared with its T-cell epitope synthetic peptide in mice. The results showed that both Hsp16.3 and its synthetic peptide induced ... New investigation results, 'New alternative vaccine component against mycobacterium tuberculosis--heat shock protein 16.3 or its T-cell ...
2009 NOV 24 ... New research, 'A recombinant hybrid peptide composed of AAF adhesin of enteroaggregative Escherichia coli and Shiga toxin B subunit ... indicate that this kind of polypeptide strategy is a good candidate for any probable vaccine design against diarrheal infection." Oloomi and colleagues published their ...
2009 NOV 23 ... its potency as an antiviral vaccine. The intramuscular immunization of mice with the peptide-liposome conjugates along with CpG resulted in the efficient induction of antiviral ...
2009 NOV 9 ... to an amino acid sequence within a conserved region in the N terminus of Polio 1 VP1 by peptide and competition enzyme-linked immunosorbent assay. Two additional MAbs, an EV70-specific ... Clinical Microbiology, Coxsackievirus, Monoclonal Antibody, Polio Immunization, Polio Vaccine, Polio Virus, Poliomyelitis, Vaccination, Virology. This article was ...
2009 NOV 23 ... the way toward the rational design of an efficacious vaccine. We exploited self-cleaving peptide 2A from the foot-and-mouth disease virus, because of its small size and high cleavage ...
2009 NOV 16 ... Keywords: United Kingdom, Cambridge, Salmonellosis Therapy, Antimicrobials, Enzymes, Peptide, Phosphoglucomutase, Proteins, Proteomics, Salmonella, Therapy, Treatment. ... concluded: "Although pgm mutants in other pathogens have potential as live attenuated vaccine strains, SL1344 pgm was not sufficiently attenuated for such use." ...
2009 NOV 2 ... genetic mutations, which lead to the generation of immunologically foreign antigenic peptide repertoire with the potential to induce individual tumor-specific immune responses. ... induce individual tumor-specific immune responses. Here, we developed an in situ tumor vaccine with the ability to elicit antitumor immunity." "This vaccine comprised ...
2009 NOV 16 ... a high level of expression of specific class I major histocompatibility complex (MHC)/peptide complexes at the cell surface. An epitope-linked beta 2-microglobulin (beta 2m) molecule ... CTL responses in vivo is still unknown. In this study, we modified the PIA tumor cell vaccine by addition of the tumor-associated epitope (TAE)-linked beta 2m molecule and ...
2009 NOV 16 ... person and specific for the immunodominant HLA-A(*)02-restricted, HIVgag-specific peptide SLYNTVATL (SL9). High-affinity (KD < 400 pM) TCRs were produced that bound with a ... over 33 million people estimated to be living with HIV worldwide. No cure or effective vaccine yet exists. Current treatment regimens are based on combinations of different classed of ...
