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2009 APR 6 -- "No effective therapy is available for treating intracerebral hemorrhage (ICH). One of several key components of brain damage after ICH is the neurotoxicity of blood products," scientists writing in the journal Stroke report.
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2009 FEB 9 -- Scientists discuss in 'Peroxisome proliferator-activated receptor gamma agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity' new findings......
2009 FEB 2 -- According to a study from the United States, "Brain tumour stem cells (BTSCs) are a small population of cells that has self-renewal, transplantation, multidrug resistance and recurrence properties, thus remain novel therapeutic target for......
2009 AUG 10 -- "Human proximal tubular epithelial cells (PTEC) were pre-treated with increasing concentration of a PPAR-gamma agonist rosiglitazone or troglitazone (0-5 mc M) followed by further incubation with the conditioned medium (IgA-HMC) collected from......
2009 SEP 7 -- According to recent research from Rome, Italy, "Several lines of evidence suggest that peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists may control brain inflammation and, therefore, may be useful for the treatment of human......
2009 JUN 23 -- According to a study from Taiwan, "Utilizing medicinal chemistry design strategies Such as benzo splitting and ring expansion, we converted PPAR alpha/gamma dual agonist 1 to selective PPAR gamma agonists 19 and 20."
"Compounds......
2009 APR 20 -- "Drug-induced acute interstitial nephritis is a well-recognised and important reversible cause of acute renal failure. Peroxisome-proliferator activated receptor-gamma agonists, such as rosiglitazone, have been proven to be safe in chronic......
2009 JUN 23 -- "CXC alpha-chemokine CXCL10/IP-10 plays an important role in the initial phases of Graves' ophthalmopathy (GO). Human thyrocytes, orbital fibroblasts, and preadipocytes are stimulated to produce CXCL10 when treated with interferon gamma(IFN......
2009 OCT 12 -- According to recent research from the United States, "White adipose tissue (WAT) stores energy in the form of triglycerides, whereas brown tissue (BAT) expends energy, primarily by oxidizing lipids. WAT also secretes many cytokines and......
2009 OCT 5 -- According to recent research from Toronto, Canada, "Despite the use of potent antimalarial drugs, the fatality rate associated with severe malaria remains high. Adjunctive therapies that target the immunopathological responses to infection may......
2008 DEC 1 -- According to recent research published in the journal Chemical Biology & Drug Design, "Peroxisome proliferator-activated receptor-gamma offers a molecular target for drugs aimed to treat type II diabetes mellitus, while its therapeutic potency......
2008 JUL 14 -- Researchers detail in 'Regulation of TLR2 expression by prostaglandins in brain glia,' new data in life sciences. According to a study from Korea, "TLR have emerged as important primary sensors for diverse stimuli and are increasingly......
2008 JUN 9 ... Fresh data on life sciences are presented in the report 'Peroxisome proliferator activated receptor gamma agonists suppress TNFalpha-induced ICAM-1 expression by endothelial cells in a manner potentially ...
2008 MAR 17 -- Fresh data on life sciences are presented in the report 'Immunomodulatory role of PPAR-gamma in alveolar macrophages.' "The lung is constantly exposed to inhaled pathogens and toxins yet totally dependent on the integrity of a delicate......
2008 DEC 1 -- " Peroxisome proliferator-activated receptor gamma (PPAR gamma) agonists can cause peripheral edema in susceptible individuals. To investigate the mechanistic basis underlying this adverse event we performed a candidate gene analysis of patients......
2008 MAY 19 -- New research, 'Gene alterations by peroxisome proliferator-activated receptor gamma agonists in human colorectal cancer cells,' is the subject of a report. According to a study from the United States, "The peroxisome proliferator-activated......
2008 JUN 23 -- "Purpose of review The thiazolidinediones are agonists for peroxisome proliferator-activated receptor-gamma, and promote insulin sensitization and improve dyslipidemia in patients with type II diabetes mellitus. Peroxisome proliferator-activated......
