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2009 NOV 16 ... proof-of-concept studies, i.e. in parallel to safety and PK measurements, to evidence pharmacodynamic effects as soon a! s pre-clinical and early clinical development. In ...
2009 NOV 16 ... occurred earlier with ultra-rapid acting Nasulin than with rapid acting lispro. The pharmacodynamic profile indicates Nasulin has optimum activity when glucose levels rise during a meal ...
2009 NOV 16 ... free drug area under the concentration-time curve [fAUC(24)]/MIC) using an in vitro pharmacodynamic model and population-based mathematical modeling," investigators in the United States ...
2009 NOV 23 ... A report, 'Pharmacokinetic and pharmacodynamic modelling of the novel human granulocyte colony-stimulating factor derivative Maxy-G34 ...
2009 NOV 16 ... a Potent gamma-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties. Cancer Research, 2009;69(19):7672-7680). For additional ...
2009 NOV 23 ... to the IFN molecule, drastically modifying the immunological, pharmacokinetic and pharmacodynamic properties of the drug," wrote A. Aghemo and colleagues, University of Milan. ...
2009 NOV 16 ... published their study in Antimicrobial Agents and Chemotherapy (Pharmacokinetic and Pharmacodynamic Evaluation of Liposomal Amikacin for Inhalation in Cystic Fibrosis Patients with Chronic ...
2009 NOV 16 ... in the Journal of Pharmacy and Pharmacology (Retrospective population pharmacokinetic/pharmacodynamic analysis of pyridostigmine, a cholinesterase inhibitor, in Chinese males. Journal of ...
2009 NOV 23 ... (CRS) are increasing worldwide." "This study assessed the in vitro pharmacodynamic activity of tigecycline against E. coli with ESBLs, AmpCs and CRS. Nine E. coli ...
2009 NOV 16 ... Lip to the last sample (AUC(0-tz)) and maximum concentration (C-max) of 5-HMT in plasma. Pharmacodynamic variables included spontaneous salivary secretion (Studies I and 2) and residual urine ...
2009 NOV 16 ... their study in Antimicrobial Agents and Chemotherapy (Cellular Accumulation and Pharmacodynamic Evaluation of the Intracellular Activity of CEM-101, a Novel Fluoroketolide, against ...
2009 NOV 23 ... showed that the prepared BLH were no irritation to both the broken and integrity skin. Pharmacodynamic evaluation revealed that the BLH showed a better therapeutic efficacy than that of the ...
2009 NOV 16 ... was injected into immunocompromised mice for pharmacokinetic and metastasis studies. Pharmacodynamic studies compared histone acetylation, apoptosis, proliferation, and DNA damage in vitro ...
2009 NOV 16 ... both healthy animals and models of disease. Furthermore, linagliptin exhibited prolonged pharmacodynamic activity, with long-lasting DPP-4 inhibition across different species. The prolonged ...
2009 NOV 16 ... for only the most-resistant isolates, the ability of increased doses to achieve pharmacodynamic targets and the efficacy observed when these targets were attained could prove useful ...
2009 NOV 16 ... concentrations of drug directly to the site of infection and attains pharmacokinetic-pharmacodynamic indices exceeding those which can be achieved with systemic dosing," scientists in the ...
2009 NOV 16 ... cohort study characterized ambulatory blood pressure monitoring as an early pharmacodynamic biomarker of VEGF signaling pathway inhibition by sorafenib," researchers in the United ...
2009 NOV 9 ... 1 mg/kg or placebo, followed by an infusion of 1 mg/kg or placebo. The primary pharmacodynamic end point was the change in alpha(2)-AP activity, measured at different time points up ...
2009 NOV 23 ... Western Psychiatric Institute. The researchers concluded: "Because pharmacodynamic changes associated with aging will make elderly patients more sensitive to the ...
2009 NOV 16 ... the 12:30 pm - 2:30 pm poster session (Abstract #C197) Biomarker Data Presentations Pharmacodynamic and correlative biomarker analyses in clinical trials of XL184, an oral, potent ...
