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2009 AUG 17 ... groundbreaking, involving research into the relationship between a protein called presenilin and the brain's way of regulating calcium concentrations. Dr. Foskett has shown that ...
2009 AUG 3 ... groundbreaking, involving research into the relationship between a protein called presenilin and the brain's way of regulating calcium concentrations. Dr. Foskett has shown that ...
2009 NOV 30 ... Pen2 mRNA levels and its promoter transactivation. Furthermore, overexpression of presenilin-1 lowers Pen2 promoter transactivation, a phenotype abolished by a double mutation known ...
2009 OCT 12 ... According to a study from Case, France, "Presenilin 1 (PS1) mutations are responsible for a majority of early onset familial Alzheimer's ...
2009 SEP 14 ... According to recent research from Yokohama, Japan, "Presenilin 1 (PS1) has been identified as a causative gene for the early-onset of familial ...
2009 AUG 17 ... the pathogenesis of Alzheimer's disease (AD). In order to determine if mutations of presenilin-1 (PS-1) affect levels of mitochondrial proteins at different ages we enriched ...
2009 AUG 24 ... raft and non-raft domains. The cleavage product, L1-32, is further processed by PS (presenilin)/gamma-secretase to release L1-ICD, an L1 intracellular domain of 28 kDa. Overexpression ...
2009 SEP 28 ... 6- to 12-month-old double transgenic mice over-expressing human APPswe and mutant presenilin 1 with exon 9 deletion (APPswe/PS1-dE9) were compared with background controls of ...
2009 SEP 7 ... levels of the amyloid precursor protein (APP), APP C-terminal fragments (C100), and presenilin-1 were examined semiquantitatively by Western blot as markers of APP processing. Markers ...
2009 AUG 17 ... "In this study, employing the transgenic mouse model, we explored the effect of presenilin 1 (PS-1) mutation on the phosphorylation and distribution of NFs. Western blot analysis ...
2009 OCT 12 ... transgenic mice (3xTg- AD) that express pathogenic forms of amyloid precursor protein, presenilin, and tau to investigate the effect of neural stem cell transplantation on AD- related ...
2009 JUL 27 ... we applied a fluorescence resonance energy transfer (FRET)-based technique to study APP-Presenilin 1 (PS1) interactions and lipid rafts in intact cells. Our data indicate that cholesterol ...
