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2009 JUL 20 ... cord blood cells were transplanted into immunodeficient mice, the telomeres of the most primitive regenerated human hematopoieticcells lost approximately 3 kb, indicative of more than ...
2009 NOV 23 ... of several neurotransmitter receptors was demonstrated on HSPC, mainly on the more primitive CD34(+)/CD38(-/low) fraction. The myeloid cytokines, G-CSF and GM-CSF, dynamically ... and repair mechanism. Here, we review the emerging evidence for regulation of human hematopoietic stem and progenitor cells (HSPC) by the nervous system both directly and indirectly via ...
2009 JUL 27 ... up-regulated alpha(4)beta(1) and alpha(5)beta(1) integrin-dependent adhesion of both primitive and committed HPC. LTD4-triggered adhesion was inhibited by specific CysLT, antagonists. ... According to a study from Tubingen, Germany, "Cytokines and chemokines control hematopoietic stem and progenitor cell (HPC) proliferation and trafficking. However, the role of ... tyrosine kinase Pyk2, which is linked to integrin activation. Bone marrow stromal cells produced biologically significant amounts of cysteinyl leukotrienes only when ...
2009 JUN 22 ... in the journal Hematology, "Umbilical cord blood (UCB) contains a high number of primitive progenitor cells, allowing UCB to be used as a source of hematopoietic progenitors for ...
2009 JUL 6 ... in hematopoiesis were profiled and indicate differentiating ES cells undergo a wave of primitive hematopoiesis (Day 3.75) similar to the mouse yolk sac, followed by a wave of more ... lineage commitment. To ascertain which Wnt proteins and receptors are important during hematopoietic development, we used two systems; in vitro hematopoietic differentiation of embryonic ...
2009 OCT 12 ... are generated from a bipotent megakaryocyte-erythroid progenitor (MEP). In the mouse, a primitive MEP has been demonstrated in the yolk sac." "In human, it is not known ... MK and erythroid lineages are generated from a common progenitor or independently. Using hematopoietic differentiation of human embryonic stem cells on the OP9 cell line, we identified a ...
2009 JUN 29 ... cells."
"The results of EPC colony-forming assays reveal that small (primitive) EPC colony formation by CD34(-) KSLs and large (definitive) EPC colony formation by ... and modulators are not clear. Here, we demonstrate that Lnk, a negative regulator of hematopoietic stem cell proliferation, controls endothelial commitment of c-kit(+)/Sca-1(+)/Lineage(-) ...
2009 JUN 15 ... demonstrate that the cells selected by GD2 are a subpopulation of MSCs with feature of primitive precursor cells and provide evidence that GD2 can be a cell surface marker suitable for ... published in the journal Cellular Physiology and Biochemistry, "In contrast to hematopoietic stem cells, there is still a lack of definitive cell markers for specific isolation and ...
2009 AUG 24 ... making it an ideal disease in which to study the transforming potential of less primitive cell types. We utilized a murine model of APL in which the PML-RARalpha oncogene is ... data indicate that PML-RARalpha alone can confer properties of self-renewal to committed hematopoietic progenitors before the onset of disease," wrote S. Wojiski and colleagues, Brigham and ... concluded: "These findings are consistent with the hypothesis that cancer stem cells may arise from committed progenitors that lack stem cell properties, provided that the ...
2009 AUG 10 ... data indicate that tyrosine phosphorylation via CD44 is involved in the survival of primitive myeloid cells." Onoda and colleagues published their study in Hematology ... a human myeloid cell line,' is the subject of a report. "Adhesive interactions between hematopoietic progenitor cells and extracellular matrix can improve progenitor cell survival. These ...
2009 NOV 16 ... be completely ruled out, the preferential effect of ADAR1 absence on HPCs over more primitive hematopoietic cells was consistent with the increased expression of ADAR1 within HPCs, as well as the ...
2009 NOV 2 ... cell-derived factor-1 alpha with VCAM-1 strengthened this adhesion. Transfusion of primitive (CD71+) or more mature (Ter119+) erythrocytic precursors into mice showed that both ... precursors into mice showed that both populations selectively and efficiently home to hematopoietic tissues. Our results demonstrate that erythrocytic precursor cells of different ...
2009 JUL 27 ... means of understanding the proliferative and renewal properties of normal and malignant primitive human hematopoietic stem cells. Louis M. Staudt, M.D., Ph.D., of the ...
2009 JUL 27 ... overlapped with that of neural and embryonic stem cells, further demonstrating their primitive, uncommitted phenotype. Following subcutaneous transplantation in nonimmunosuppressed ... characteristic of mesenchymal stem cells. However, they were negative for markers of hematopoietic stem/progenitor cells and bone marrow cell lineages. MPCs had a cloning efficiency of ...
2009 OCT 12 ... obtained by PMPR alone generally demonstrated a significant increase in percentages of primitive HSC phenotype with equivalent cell viability between PMPR and venipuncture," wrote N. ... "Umbilical cord blood (CB) use is limited in most adults since the mean amount of hematopoietic stem cells (HSCs) collected is generally insufficient to engraft successfully. This ...
2009 JUN 1 ... CD43(+) cells could be separated into the following phenotypically defined subsets of primitive hematopoietic cells: CD43(+)CD235a(+)CD41a(+/-) (erythromegakaryopoietic), lin(-)CD34(+)CD43(+)CD45(-) ...
2009 AUG 31 ... phenotype signifies a developmentally immature population of cells with features of both primitive and mature HSC," wrote S.L. Mckinneyfreeman and colleagues, Columbus Children's ... According to recent research from the United States, "Surface antigens on hematopoietic stem cells (HSCs) enable prospective isolation and characterization. Here, we compare ...
2009 JUL 27 ... "Vertebrate hematopoiesis first produces primitive (embryonic) lineages and ultimately generates the definitive (adult) blood. Whereas ... The researchers concluded: "Our results demonstrate the existence of primitive hematopoietic progenitors that are segregated very early in development and that are specified to ... different progenitor types. On the dorsal gastrula, blood progenitors are unipotential cells that divide infrequently, populate the rostral blood islands, and differentiate into ...
2009 AUG 24 ... "The molecular mechanisms that underlie the development of primitive myeloid cells in vertebrate embryos are not well understood. Here we characterize the ... the United Kingdom report. "We show that cebpa is one of the first known hematopoietic genes expressed in the embryo. Loss- and gain-of-function studies show that it is both ...
