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2009 FEB 23 ... metastatic lesions in murine and human patient samples. Finally, we showed that the promigratory effects of PKC were linked to ezrin phosphorylation," wrote L. Ren and colleagues, ... To pursue mechanisms for this regulation, we found that inhibitors of PKC (protein kinase C) blocked phosphorylation of ezrin, and that ezrin coimmunoprecipitated in cells with ...
2009 JAN 26 ... changes were concomitant with sustained activation of the downstream prosurvival and promigratory signaling pathways, including Src kinase, phosphatidylinositol 3-kinase/Akt1/endothelial ...
2009 MAY 25 ... a dose-dependent antagonist when Ang1 is present. Exogenous Ang2 activates Tie2 and the promigratory, prosurvival PI3K/Akt pathway in ECs but with less potency and lower affinity than ... was originally shown to be a competitive antagonist for Ang1 of the receptor tyrosine kinase Tie2 in endothelial cells (ECs). Since then, reports have conflicted on whether Ang2 is ...
2009 FEB 23 ... null keratinocytes. Thus, activation of CXCR2 on ras-transformed keratinocytes has both promigratory and protumorigenic functions," wrote C. Cataisson and colleagues, National Institutes ... keratinocytes and for ligand activation of the extracellular signal-regulated kinase (ERK) and Akt pathways. Both migration and activation of ERK and Akt were restored by ...
2009 FEB 2 ... migration paths of mammary epithelial cells (expressing different versions of the promigratory tyrosine kinase receptor Her2/Neu) were analyzed within a bimodal framework that is a ...
2007 MAY 22 ... of mitogen-activated protein kinase; moreover, inhibition of this pathway blocked the promigratory effect of calponin 2."
"Collectively, these data suggest that calponin ...
Subject: Beth Israel Deaconess Medical Center, Boston, U.S.
2007 APR 3 ... of mitogen-activated protein kinase; moreover, inhibition of this pathway blocked the promigratory effect of calponin 2."
"Collectively, these data suggest that calponin ...
Subject: Beth Israel Deaconess Medical Center, Boston, U.S.
2006 DEC 8 ... of mitogen-activated protein kinase; moreover, inhibition of this pathway blocked the promigratory effect of calponin 2."
"Collectively, these data suggest that calponin ...
2007 MAR 28 ... of mitogen-activated protein kinase; moreover, inhibition of this pathway blocked the promigratory effect of calponin 2."
"Collectively, these data suggest that calponin ...
Subject: Beth Israel Deaconess Medical Center, Boston, U.S.
2008 DEC 29 ... VSMC proliferation through the delayed nuclear export and degradation of p27Kip1. This promigratory phenotype resulted from increased stathmin protein levels, caused by a lack of ... "Vascular proliferative diseases are characterized by VSMC proliferation and migration. Kinase interacting with stathmin (KIS) targets 2 key regulators of cell proliferation and ...
2006 DEC 19 ... of mitogen-activated protein kinase; moreover, inhibition of this pathway blocked the promigratory effect of calponin 2."
"Collectively, these data suggest that calponin ...
Subject: Beth Israel Deaconess Medical Center, Boston, U.S.
2006 NOV 27 ... of mitogen-activated protein kinase; moreover, inhibition of this pathway blocked the promigratory effect of calponin 2."
"Collectively, these data suggest that calponin ...
Subject: Beth Israel Deaconess Medical Center, Boston, U.S.
2007 JUN 5 ... exclusively in CD4 and CD8 single positive T cells and promotes a nonproliferative, promigratory phenotype. In mice exposed to TCDD, however, the Klf2 gene is prematurely expressed in ... KLF2 regulon, including Edg1/S1P(1), beta(7) integrin, CD52, Cdkn2d (cyclin-dependent kinase inhibitor 2D), s100a4, and IL10R alpha," wrote B.J. McMillan and colleagues, University ...
2007 JUN 12 ... to recent research from the United States, tumor cell motility is modulated by MAP4K4 promigratory kinase.
"Cell motility is a complex biological process, involved in ...
2007 FEB 2 ... of mitogen-activated protein kinase; moreover, inhibition of this pathway blocked the promigratory effect of calponin 2."
"Collectively, these data suggest that calponin ...
2008 OCT 13 ... involved in synergistic interactions between Aldo and Ang II and that it is upstream of promigratory signaling pathways in vascular smooth muscle cells (VSMCs). VSMCs from WKY rats were ... "We tested the hypothesis that c-Src activation, through receptor tyrosine kinase transactivation, is critically involved in synergistic interactions between Aldo and Ang ...
2007 JAN 8 ... of mitogen-activated protein kinase; moreover, inhibition of this pathway blocked the promigratory effect of calponin 2."
"Collectively, these data suggest that calponin ...
Subject: Beth Israel Deaconess Medical Center, Boston, U.S.
2008 JUN 9 ... in both Boyden chamber and in vitro wound repair assays."
"This promigratory effect was mimicked by 2-MeSADP, but not by AMP, and was inhibited by MRS2179 (P2Y(1) ... In addition, both ADP and 2-MeSADP, but not AMP, activated the mitogen-activated protein kinase pathways as evidenced by increased phosphorylation of extracellular signal-regulated ...
2007 OCT 8 ... previously shown that the serum factor sphingosine 1-phosphate stimulates MT1-MMP promigratory function through a process that involves its cytoplasmic domain, we now extend these ... leads to enhanced cellular migration through downstream extracellular signal-regulated kinase activation. The present study, thus, elucidates a novel role of MT1-MMP in signaling ...
