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2009 OCT 5 ... decreased Pin1 activity leads to robust Spt23 polyubiquitylation and subsequent proteasomal degradation. Inhibition of Pin1 in mammalian cells changes the ubiquitylation status of ...
2009 OCT 19 ... maintenance of a functional proteasome in the healthy cell, based on the premise that proteasomal activity can be titrated out by mature aSN fibrils and their protofilament precursors." ...
2009 OCT 5 ... in ovarian cancer cells. SHetA2 induced cyclin D1 phosphorylation, ubiquitination, and proteasomal degradation, causing G, arrest in ovarian cancer cells despite continued cyclin E2 ... phosphorylation of pRb S612 by cyclin E2-cdk2 and ultimately E2F-DP transcriptional activity. G, arrest was prevented by overexpression or preventing degradation of cyclin D1 but ...
2009 NOV 9 ... the hedgehog-inducible WSB-1. Ubiquitinated D2 can then be subsequently taken up by the proteasomal system or be reactivated by USP-33/20-mediated deubiquitination," investigators in the ... TEB4 and D2 could be coimmunoprecipitated, and additional TEB4 expression decreased D2 activity by similar to 50% (P < 0.05). A highly efficient TEB4 knockdown (>90% reduction in ...
2009 OCT 12 ... ubiquitin ligase known to inhibit tumor suppressor p53 function via ubiquitination and proteasomal degradation. We have identified two novel Pirh2 splice variants that encode different ... each isoform results in a RING domain deletion and the abrogation of ubiquitin ligase activity. Our findings further indicate that the Pirh2B isoform but not the Pirh2C isoform is ...
2009 NOV 2 ... formation (6-12). Lnx-l induced K48-linked polyubiquitylation of Boz, leading to its proteasomal degradation in human 293T cells and in zebrafish embryos. Dorsalization induced by Boz ... Institutes of Health. The researchers concluded: "Lnx-I modulates Boz activity to prevent the invasion of ventral regions of the embryo by organizer tissue. These ...
2009 OCT 20 ... in the regulation of apoptosis and NF kappa B activity, as well as in ubiquitination and proteasomal degradation," wrote C.W. Menges and colleagues. The researchers concluded: ...
2009 OCT 20 ... that requires polyubiquitin receptors. We show here that the concentrations of the proteasomal and extraproteasomal polyubiquitin receptors change in a developmentally regulated ... is due to the emergence of a developmentally regulated selective proteolytic activity. To follow the fate of subunit p54/Rpn10 in vivo, transgenic Drosophila melanogaster ...
2009 NOV 9 ... ER stress and cell dysfunction, caspase activation, p23 cleavage and inhibition of proteasomal activity in dopaminergic N27 cells," wrote S.J. Chinta and colleagues. The ...
2009 OCT 19 ... demonstrated that human immunodeficiency virus type 1 (HIV-1) Vif failed to mediate A3G proteasomal degradation when all 16 lysines were mutated to arginines. Here, we show that K26, and ... concluded: "Thus, (21)WxSLVK(26) is a novel functional domain that regulates Vif activity toward both A3F and A3G and is a potential drug target to inhibit Vif activity and block ...
2009 NOV 16 ... NSP1's ability to degrade IRF3 is host cell dependent and is independent of NSP1 proteasomal degradation." Sen and colleagues published the results of their research ... is the ability of transiently expressed UK NSP1 to inhibit poly(I:C)-directed IRF3 activity in NIH 3T3 cells in the absence of detectable IRF3 degradation, an unexpected finding ...
2009 OCT 6 ... marker protein, p21(WAF-1), protection against oxidative damage, and induction of proteasomal activity," wrote N. Widodo and colleagues. The researchers concluded: "To the best ...
2009 SEP 15 ... causes inhibition of Mcl-1 mRNA translation and rapid destruction of Mcl-1 protein by proteasomal degradation mediated by a phosphodegron created by glycogen synthase kinase 3 (GSK3) ... by GSK3. Stress-induced Mcl-1 degradation therefore requires the coordinated activity of JNK and GSK3," wrote C. Morel and colleagues, University of Massachusetts. ...
2009 OCT 27 ... are not controlled by the proteasome activity but rather depend on a new function of the proteasomal lid subunit Rpn11. Rpn11 was found to regulate the Fis1-dependent fission machinery of ...
2009 SEP 21 ... factors (HIFs) by hydroxylation of proline residues targeting HIF-1 alpha for proteasomal degradation. using the purified catalytic domain of prolyl hydroxylase 2 ( ... and formation of [C-14]-succinic acid was measured to quantify pHd2(181-417) enzymatic activity. comparison of the separation of 2-oxoglutaric acid and succinic acid by either ion ...
2009 NOV 2 ... and is enhanced by the chaperone Hsp90, which cycles dynamically with the enzyme. The proteasomal degradation or nNOS is enhanced by suicide inactivation and by treatment with Hsp90 ... same interaction of Hsp90 with the enzyme is responsible for both enhancement of nNOS activity and inhibition of ubiquitination. It is established that CHIP binds to Hsp90 as well as ...
2009 OCT 19 ... Molecular Pharmacology report. "Consistent with this, we have shown that proteasomal inhibitors N-benzoyloxycarbonyl (Z)-Leu-Leu-leucinal (MG132) and ... such CYP3A suppression could be due to ER stress induction, so we monitored the activity of PERK [PKR (RNA-dependent protein kinase)like ER kinase (EIF2AK3)], the ER ...
2009 OCT 5 ... inhibition of threonine-187 phosphorylation of p27(kip1) protein for ubiquitinyl-proteasomal mediated degradation was also involved in upregulation of p27(kip1)," wrote C.H. Tsai ... repressed phosphorylation of the retinoblastoma protein (Rb) mediated by cyclin D1/CDK4 activity. Conversely, siRNA against p27(kip1) expression in the cofilin overexpressing cells ...
2009 NOV 16 ... According to a study from Tainan, Taiwan, "Inhibiting proteasomal degradation has been shown to induce apoptosis in tumor cells. Utilization of proteasome ... "Some of the flavonoids can induce cell apoptosis via inhibiting proteasome 26S activity. In this study, the inhibition of 26S proteasome from pig red blood cells was analyzed ...
2009 NOV 23 ... found that an E3 ubiquitin ligase complex containing the FBXL5 protein targets IRP2 for proteasomal degradation. The stability of FBXL5 itself was regulated, accumulating under iron-and ... IRP1 and IRP2. However, the manner in which iron levels are sensed to affect IRP2 activity is poorly understood." "We found that an E3 ubiquitin ligase complex ...
