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2009 NOV 23 ... interleukin 1. Immunization with a LEAPS-immunogen for herpes simplex virus activates a protective T cell immune response against the virus in mice while a LEAPS-immunogen for treatment ... produce and activate a specific type of dendritic cell that can turn on or modulate antigen specific T cell responses without generating the pro-inflammatory cytokines associated ...
2009 NOV 16 ... binding ligand (TCBL) which previously has demonstrated the ability to induce and elicit protective immunity and antigen-specific antibody production in animal models. Thus, extensive ...
2009 NOV 23 ... promise but require the use of adjuvants to enhance their immunogenicity. Using the protective mycobacterial antigen Rv3019c, we have evaluated the induction of relevant immune ...
2009 NOV 23 ... nucleoprotein (NP) that triggered cytotoxic T-cell responses. These responses were also protective when epitope-specific splenocytes were transferred into naive animals. Epitope mapping ... multiple overlapping 15-mer peptide pools, and reactive CD8+ T cells were evaluated for antigen specificity by measuring upregulation of CD44 and interferon-gamma expression. After ...
2009 NOV 3 ... report 'Nondividing but metabolically active gamma-irradiated Brucella melitensis is protective against virulent B. melitensis challenge in mice.' "Brucella spp. are gram-negative ... possessed metabolic and transcriptional activity, persisted in macrophages, generated antigen-specific cytotoxic T cells, and protected mice against virulent bacterial challenge, ...
2009 NOV 23 ... the United States, "Cancer-derived heat shock protein gp96 induces a tumor-specific protective immune response primarily mediated by cytotoxic T lymphocytes (CTL) directed toward ... occur for an immune response to be generated is the interaction between gp96 and the antigen presenting cell (APC) surface receptors (CD91, SR-A, TLR-2, and TLR-4). Our previous ...
2009 NOV 23 ... Executive Officer. "New data from our Valortim=AE and third generation (3G) recombinant protective antigen (rPA) anthrax vaccine programs were presented at the Bacillus - ACT 2009 annual meeting ...
2009 NOV 23 ... to assess the development and in utero transfer of antibodies to Bacillus anthracis protective antigen (anti-PA IgG). Half of the does underwent Caesarean-sectioning on gestation day 29 and a ...
2009 NOV 24 ... for fibronectin in the range of 37-92 kDa. The 70 kDa adhesin was also recognized by a protective monoclonal antibody raised against a gp70 antigen of S. schenckii (mAb P6E7). Confocal ...
2009 NOV 3 ... scientists in the United States report. "Since the O antigen is a protective antigen for many pathogenic bacteria, we examined whether this factor is a potential...
2009 NOV 23 ... observed in the J774A.1 cell-based assay was dependent on the concentration of protective antigen utilized in the assay. Our results suggest that the characteristics of the antibodies ...
2009 NOV 23 ... In individuals greater than 55 years of age, the probability of developing a fully protective neutralizing antibody response to the yearly multivalent particle inactivated influenza ... response to vaccination in the older age groups include functional defects of the antigen presenting cells, functional defects in CD4 helper CD4 T cells and monocytes, and an ...
2009 NOV 9 ... According to a study from the United States, "Protective antigen (PA), the binding subunit of anthrax toxin, is the major component in the current ...
2009 NOV 23 ... The researchers concluded: "It is clear from these results that recombination of protective antigen genes lipL32, lipL41, and ompL1 and a DNA-protein immune strategy resulted in better ...
2009 NOV 9 ... China during 1998 and 2003, which prompted the public health authorities to seek protective strategies to control H9N2 influenza viruses." "In this study, we ... genetics and employed an enzyme-linked immunosorbent assay ( ELISA) with a truncated N1 antigen expressed in E. coli to differentiate between vaccinated and naturally infected animals. ...
2009 NOV 23 ... gondii antigens trigger a systemic Th1-biased specific immune response and induce protective and specific antitoxoplasma immunity." "In the present study, we ... immunity." "In the present study, we demonstrate that tumor antigen-pulsed DCs matured in the presence of Toxoplasma gondii components induce a potent ...
2009 NOV 17 ... we identified Spy0416, annotated as ScpC, as a prominent antigen that induces protective immune responses in animals. We demonstrate here for the first time that the recombinant ...
2009 NOV 9 ... the MAbs, LF10E and LF11H, neutralized lethal toxin ( LT), a complex of LF and anthrax protective antigen (PA)." "LF10E has the highest reported affinity for a neutralizing MAb ...
2009 NOV 2 ... monoclonal antibodies directed against defined linear epitopes on domain 4 of anthrax protective antigen,' have been published. "The anthrax...
2009 NOV 4 ... proteins which function as phenotypic markers and as antigens which are able to induce protective immunity in experimental settings. Among these proteins, the chimeric and ... recorded findings which suggested that strain 10/84 expressed a strain-variable protein antigen, in addition to R3. The antigen was detected by various enzyme-linked immunosorbent ...
