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2009 NOV 27 ... the conformational dynamics of linear, nicked, gapped, and bulged DNA in the absence of protein enzymes. This analysis reveals that damaged DNA is polymorphic in nature and able to ... Arizona State University.The researchers concluded: "Because changes in DNA conformation appear to guide the recognition of DNA repair enzymes, we Suggest that the current ...
2009 NOV 23 ... enzyme, was chosen as a model enzyme to clarify the recognition mechanism of structural protein substrates in serine proteases. We have found previously that the topological ... residue 71 of SOT was also found to be crucial for catalytic efficiency and enzyme conformation." Uesugi and colleagues published their study in Febs Journal (The role of ...
2009 NOV 23 ... the United States, "Native Chlamydia trachomatis mouse pneumonitis major outer membrane protein (nMOMP) induces effective protection against genital infection in a mouse challenge ... induces effective protection against genital infection in a mouse challenge model. The conformation of nMOMP is crucial to confer this protective immunity." "To achieve a ...
2009 NOV 27 ... 15 mu m). The binding of Ca2+ resulted in a more compact conformation of the engineered protein. Our results also showed that D to A mutations at Ca2+-coordinating loop positions 1 and ...
2009 NOV 16 ... Life Sciences, Oncology, Tumor Vascularization, Angiogenesis, Thrombosis, Hematology, Protein Structure, Proteomics, Proteins, Cleveland Clinic. This article was ... of integrin alpha IIb beta 3 TMCD heterodimer, which reveals a right-handed coiled-coil conformation with 2 helices intertwined throughout the transmembrane region. The helices extend into ...
2009 NOV 24 ... whose recruitment function is inhibited in the absence of galactose by the Gal80 protein through masking of its transcriptional activation domain (AD). A long-standing ... at the promoter, yielding a tripartite Gal3-Gal80-Gal4 complex with altered Gal80-Gal4 conformation to enable Gal4 AD activity," researchers in the United States report. ...
2009 NOV 16 ... "The Plasmodium falciparum circumsporozoite protein (CSP) is critical for sporozoite function and invasion of hepatocytes. Given its ... pastoris (PpCSP) for structural analyses. To analyze the TSR domain of recombinant CSP, conformation-dependent monoclonal antibodies that recognized unfixed P. falciparum sporozoites and ...
2009 NOV 16 ... the transition temperature of endostar and contributed to a reversible change in protein conformation after recooling. Proteolysis assays demonstrated that the modified protein binding with ...
2009 NOV 23 ... "The binding of cAMP to the Escherichia coli catabolite gene activator protein (CAP) produces a conformational change that enables it to bind specific DNA sequences ... of the liganded and unliganded CAP suggests that cAMP stabilizes the active DNA binding conformation of CAP through the interactions that the N-6 of the adenosine makes with the ...
2009 NOV 24 ... from polyglutamine (polyQ) expansion (>36Q) within the first exon of Huntingtin (Htt) protein. We applied X-ray crystallography to determine the secondary structure of the first exon ... in the structure, including alpha helix, random coil, and extended loop. The conformation of the poly17Q region is influenced by the conformation of neighboring protein regions, ...
2009 NOV 27 ... of VSMC lysates revealed the presence of several maspin-binding proteins, with a protein of 150 kDa differentially expressed between the two VSMC phenotypes. Western blotting ... alpha 5 beta 1 was confirmed using a recombinant alpha 5 beta 1-Fc fusion protein. Using conformation-dependent anti-beta 1 antibodies, maspin binding to VSMC was found to lead to a decrease ...
2009 NOV 16 ... by aspartic acid with a loss of only 10-fold in catalytic efficiency. This is because protein backbone movements place the Asp(185) carboxylate almost coincident with the carboxylate ... of the loss of charge, but also because the variant residue does not adopt the same conformation as Glu(185)." Drinkwater and colleagues published their study in ...
2009 NOV 10 ... surface or the extracellular milieu is mediated by specific machineries, which guide the protein substrates towards the proper route of secretion and determine the compartment in which ... FHA is exported by the Sec machinery and transits through the periplasm in an extended conformation. From there it is translocated across the outer membrane by its dedicated transporter ...
2009 NOV 24 ... at this location. Deletion analysis mapped this bend to amino acids 611 to 640 of the protein sequence. The 3D structure of the collagen binding domain of EmaA was generated by ... an ellipsoidal domain capping a rod-like domain that adopts either a straight or a bent conformation at various positions along the length. The most common flexible point along the length ...
2009 NOV 24 ... molecules suggests that new targets may be exploited in vaccine development. The EtpA protein identified in ETEC H10407 is a large glycosylated adhesin secreted via the two-partner ... suggesting its functional asymmetry. The pore of EtpB frequently assumes an opened conformation and fluctuates between three well-defined conductance states. In silico analysis of the ...
