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2009 NOV 27 ... by its nature contains not just sugar necessary for the biofuel, but also lignin, protein and other materials," Sun said. "So after you convert it into biofuel, you still have ... it off, adhesives may be left on your clothes," she said. "That's why you need to design the backbone of the polymer to be strong enough to pull the sticky group ...
2009 NOV 26 ... (FBDD) platform into an integrated system for drug discovery. Driven by computational protein modeling and FBDD technology, Ansaris' technology supports rapid discovery of novel ... drug discovery computational platform and 10 years' experience in integrated drug design, discovery, and development. Ansaris establishes collaborations and partnerships with ...
2009 NOV 27 ... 15 mu m). The binding of Ca2+ resulted in a more compact conformation of the engineered protein. Our results also showed that D to A mutations at Ca2+-coordinating loop positions 1 and ... information, contact J.J. Yang, Georgia State University, Dept. of Chemical, Center Drug Design & Advanced Biotechnology, Atlanta, GA 30303, USA.Publisher contact ...
2009 NOV 23 ... "Over the last 30 years, evidence has been gathered suggesting that merozoite Surface protein 1 (MSP1) is a target of protective immunity against malaria. In a variety of ... and identify the improvements required. Understanding the structure of MSP1 will help us design and engineer better antigens that are more effective than the first generation of ...
2009 NOV 23 ... proteasome' new findings in breast cancer. "We aimed to identify putative predictive protein biomarkers of radioresistance. Three breast cancer cell lines (MCF7, MDA-MB-231, and ... Therapy, Biotechnology, Breast Cancer, Breast Carcinoma, Drug Development, Experimental Design, Neoplasia, Oncology, Pharmaceuticals, Proteomics, Therapy, Treatment, Women's Health. ...
2009 NOV 24 ... functions, where it acts not only as an affinity linker, preventing non-specific protein adsorption to the membrane surface but also non-covalently hydrophilises the membrane ... concluded: "This technology is scalable (due to the multi-variant membrane module design), able to resist non-specific protein adsorption and can be regenerated and re-used (up ...
2009 NOV 24 ... which mediates toxicity, and a B subunit (StxB), which is a nontoxic homopentameric protein responsible for toxin binding and internalization into target cells by interacting with ... that this kind of polypeptide strategy is a good candidate for any probable vaccine design against diarrheal infection." Oloomi and colleagues published their study ...
2009 NOV 23 ... pre-weaning dietary treatments arranged in a 2 MR feeding level (5 v. 10 l/day) X 2 MR protein content (210 v. 270g CP/kg dry matter (DM)) factorial design. MR was reconstituted at a ...
2009 NOV 24 ... values for insects at 26, 32 and 38 degrees C was achieved by offering individuals high-protein diets, high-carbohydrate diets or a choice between both. Locusts placed in a thermal ... in Locusta migratoria (migratory locusts) and used a multi-factorial experimental design to investigate relationships between growth/development and macronutrient utilization ...
2009 NOV 23 ... being investigated." "Anacetrapib is a cholesteryl ester transfer protein (CETP) inhibitor that raises HDL-C and reduces LDL-C when administered alone or with a ... Cannon and colleagues published their study in American Heart Journal (Design of the DEFINE trial: Determining the EFficacy and Tolerability of CETP INhibition with ...
2009 NOV 27 ... to study the network of interactions that allow microtubule formation. Modelling the protein-protein interface allows us to identify the amino acids responsible for tubulin-tubulin ... us to identify the amino acids responsible for tubulin-tubulin binding and thus to design peptides, which correspond to tubulin subsequences, that interfere with microtubule ...
2009 NOV 28 ... of the virus - the so-called outer coat membrane proximal region - a part of the outer protein coating next to the viral membrane that opens up and is exposed to the antibodies for ... it seeks entry into healthy cells has revealed a new direction for researchers hoping to design an effective vaccine."Our study clearly showed that we've been overlooking ...
2009 NOV 29 ... of Pittsburgh School of Medicine have described the architecture of the complex of protein units that make up the coat surrounding the HIV genome and identified in it a "seam" ... CA protein looks like and how the capsid is built will allow scientists to rationally design therapeutic compounds that interfere with assembly of the protein and affect its ...
Subject: University of Pittsburgh Schools of the Health Sciences
2009 NOV 23 ... laboratory to develop vaccines, diagnostics, and therapies. Proteomics is the study of protein structure and function, helping scientists better understand the causes of disease, ... new facility was constructed by Nielsen Builders, Inc. and designed by HOK using green design practices that limit environmental impact. The mix of office space and specialized ...
2009 NOV 23 ... is based upon the integration of biodegradable microspheres, loaded with suitable protein molecules, within scaffolds made of collagen and, in case, hyaluronic acid, which are ... hyaluronic acid, which are two of the fundamental ECM constituents. However, for the design of bioactivated gel-like scaffolds the determination of release kinetics must be ...
2009 NOV 23 ... beta-defensin-1 and beta(2)-microglobulin, respectively. However, changes in these two protein forms were also seen in healthy donors following nephrectomy implying a relationship ... investigated. The purpose of this report is to provide insight into experimental design for such investigations and potential confounding factors that can impact on such ...
2009 NOV 27 ... for the ongoing transition from fundamental analytical science to the early detection of protein biomarkers.""Aptamers are synthetic oligonucleotides that have undergone ... Fraser University.The researchers concluded: "Based on differences in the design of the DNA/RNA-modified electrodes, we classify aptamer-based electrochemical sensors ...
2009 NOV 23 ... The sera of 24 patients (64.9%) recognized the full-length Bla g 1.02 recombinant protein. Among 19 selected serum samples, 11 sera (57.9%) reacted to peptide fragment A, 5 sera ... "We suggest that these peptide fragments may be useful in allergy diagnosis and the design of novel immunotherapeutics." Yi and colleagues published their study in ...
2009 NOV 23 ... carcinoma and their correlation with the progression of human renal cell carcinoma. The protein and mRNA expression levels of SAM68 in normal renal tubular epithelial cells, renal cell ... Republic of China, Cancer, Cancer Epidemiology, Diagnostics, Experimental Design, Gastroenterology, Kidney, Nephrology, Oncology, Protein Expression, Proteins, ...
