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2009 NOV 27 ... mechanism of their transfer from the cytoplasm to the nucleus, for delivery to nuclear receptors," researchers in Milan, Italy report."A number of factors have been shown ...
2009 NOV 29 ... Chung, a postdoctoral fellow in Lambert's lab, zeroed in on one of the two receptors that mediate estrogen function in cells - estrogen receptor (ER) alpha. He crossed his ...
2009 NOV 26 ... applicable to many target classes including, but not limited to, kinases, proteases, and receptors. Drug design teams comprised of experienced computational and medicinal chemists utilize ...
2009 NOV 27 ... yeast vacuolar SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors), the SNARE chaperones Sec17p/Sec18p and the multifunctional HOPS complex, which ...
2009 NOV 25 ... by novelty was attenuated by pretraining a blockade of peripheral beta-adrenergic receptors with sotalol (6 mg/kg, i.p.). 2 revealed that novelty-induced increases in peripheral ...
2009 NOV 27 ... T3 (M) levels, and hepatic expression of genes involved in TH transport, metabolism, and receptors were evaluated in pups at the age of postnatal days (PNDs) 0, 7, 14, 21, or 35. PFOS ...
2009 NOV 27 ... of radioactivity was observed in the brain and peripheral organs expressing sigma(1) receptors."Maestrup and colleagues published their study in the Journal of Medicinal ...
2009 NOV 26 ... region. Remarkably, ARIP4 also interacts selectively with other sumoylated nuclear receptors including LRH-1, AR, and GR. Interestingly, the ATPase activity of ARIP4 was stimulated ...
2009 NOV 27 ... member of the nuclear receptor family and acts as a corepressor of a number of nuclear receptors. HNF4 alpha (hepatocyte nuclear factor 4 alpha) is a liver-enriched transcription factor ...
2009 NOV 27 ... 1 and 2 with low affinity (K-d similar to 7-12 mc M), typical of cell-cell recognition receptors. NMR binding studies showed that only a limited N-terminal region of E-cadherin, ...
2009 NOV 27 ... Relationships of Adenine and Deazaadenine Derivatives as Ligands for Adenine Receptors, a New Purinergic Receptor Family. Journal of Medicinal Chemistry, ...
2009 NOV 26 ... can alter the activity of tissue peroxisome proliferator-activated receptors (PPARs), which affect energy substrate metabolism and inflammation. However, it is ...
2009 NOV 25 ... According to a study from Budapest, Hungary, "The nuclear receptors CAR (constitutive androstane receptor) and PXR (pregnane X receptor) mediate the effects ...
2009 NOV 27 ... of extracellular domain Loop 2 can markedly affect ethanol sensitivity in glycine receptors (GlyRs) and gamma-aminobutyric acid type A receptors ...
2009 NOV 25 ... and subregion-specific suppression of LTP in mice expressing a population of mutant NMDA receptors throughout the hippocampus. Learning & Memory, 2009;16(10):635-644).For ...
2009 NOV 27 ... "Key transmembrane proteins in the innate immune system, Toll-like receptors (TLRs), have been suggested to occur in the genome of non-mammalian organisms including ...
2009 NOV 26 ... continuously monitored using time-lapse microscopy. Expression of the innate immunity receptors, the TLRs. was evaluated by semi-quantitative PCR on an epithelial/bacteria co-culture. ...
2009 NOV 25 ... Watson and colleagues, University of Texas.The researchers concluded: "NMDA receptors in the dmSTR play a role in reversal learning in the weanling rat."Watson ...
2009 NOV 29 ... the innate immune system operates," Ronald said."Because similar pairs of receptors and bacterial signaling molecules are known to exist not only in rice but also in other ...
