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2009 NOV 23 ... toxic side effects by binding to its molecular target more selectively than all trans-retinoic acid (ATRA), the current first-line treatment for APL. The FDA has granted Orphan Drug ...
2009 NOV 23 ... growth factor (TGF)-beta/IL-6 or IL-21, requires expression of the transcription factor retinoic acid receptor-related orphan receptor gamma t (ROR gamma t)." "We identify the ...
2009 NOV 23 ... aggressive form of non-melanoma skin cancer. We have determined the effects of all-trans retinoic acid (ATRA), a naturally occurring chemopreventive retinoid, on signal transducer and ...
2009 NOV 23 ... Bai and colleagues published their study in the Journal of Leukocyte Biology (All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ...
2009 NOV 23 ... identify, analyze and initiate preclinical studies on small molecules that activate the retinoic acid inducible gene I (RIG-I) pathway of the innate immune response. Dr. Gale's lab will ...
2009 NOV 23 ... and differentiation into memory B cells. Poly(I: C) (PIC), a double-stranded RNA, and retinoic acid (RA), a metabolite of vitamin A which induces cell differentiation, have been shown to ...
2009 NOV 23 ... (PBL) who had a complete radiographic response following treatment with vorinostat and retinoic acid," researchers in the United States report. "This regimen was used to ...
2009 NOV 23 ... According to a study from the United States, "It has been reported that retinoic acid (RA) enhances regulatory T (T reg) cell conversion by inhibiting the secretion of ...
2009 NOV 23 ... diseases," scientists writing in the journal Differentiation report. "Retinoic acid (RA) signaling plays an important role in development. However, the role of RA signaling ...
2009 NOV 16 ... state. Parallel to this Ca2+-dependent pathway is a hormone-responsive program by which retinoic acid (RA) initiates the differentiation of BE(2) C cells toward a neuronal lineage. This is ...
2009 NOV 16 ... recapitulated endogenous Olig2 expression when R-Olig2 was induced by sonic hedgehog and retinoic acid, and GFP-positive cells could be purified by fluorescence-activated cell sorting. ...
2009 NOV 23 ... therapy. PRAME is a tumor-associated antigen and has been described as a corepressor of retinoic acid signaling in solid tumor cells, but its function in hematopoietic cells is unknown." ...
2009 NOV 16 ... of the human immune system, especially in the gut. Recent studies have revealed that retinoic acid (RA) in gut-associated dendritic cells (DCs) enhances the transforming growth factor ...
2009 NOV 23 ... Researchers detail in 'Epidermal expression of Hox1 is directly activated by retinoic acid in the Ciona intestinalis embryo,' new data in life sciences. According to recent ...
2009 NOV 16 ... (twofold, p< 0.05) after treatment of NP with GCs. Heat shock proteins and retinoic acid were induced by GCs. Ingenuity pathway analysis of all identified proteins indicated ...
2009 NOV 25 ... cells. Such Foxp3-transduced CD4 T cells and nTreg cells expressed T-bet, GATA-3, or retinoic acid-related orphan receptor (ROR)gamma t, and retroviral GATA-3 and ROR gamma t could not ...
2009 NOV 23 ... are chronic inflammatory muscle diseases. Retinoids are compounds that bind to the retinoic acid binding site of retinoic acid receptors and have ...
2009 NOV 16 ... epithelial cells. The presence of RSV replication is detected by the intracellular retinoic acid-inducible gene I (RIG-I) RNA helicase that forms a productive signaling complex with the ...
2009 NOV 27 ... has been shown that the Synechocystis cytochrome P450 enzyme CYP120A1 is a retinoic acid-binding polypeptide. In this work, we determined the reaction catalyzed by CYP120A1 and ...
