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2009 NOV 23 ... breakthrough medicines. The Company's mission is to discover, develop and commercialize small-molecule drugs to treat cancer in patients with the greatest and most urgent unmet ... inadequate. ARIAD's lead product candidate, ridaforolimus, is an investigational mTOR inhibitor in Phase 3 clinical development in patients with advanced sarcomas and is being ...
2009 NOV 23 ... focused on the application of deuterium chemistry to create novel and differentiated smallmolecule drugs. Concert's approach leverages known activity and safety of existing ... initiated a Phase 1b clinical study with CTP-518, its investigational oral HIV protease inhibitor for the treatment of HIV infection. In connection with the start of this multiple ...
2009 NOV 23 ... "Our interest is even keener because we already know there are a rich spectrum of small molecules that can bind the ATD of NMDA receptors." Without a highly ... much greater interest is the location and nature of a suspected binding site of a small molecule type that is known to bind the ATD and inhibit the action of the NMDA receptor. ... for use in moderate and severe cases of Alzheimer's. Memantine is a non-specific inhibitor of the NMDA receptor and is neither a cure nor an agent that can halt progression of the ...
2009 NOV 23 ... Contrast Media, Fluorescein, Ophthalmology, Pharmaceuticals, Pre-Trials Research, Small Molecule Inhibitor, Therapy, Treatment. This article was prepared by Biotech Business Week ...
2009 NOV 23 ... study in the Journal of Medicinal Chemistry (Identification and Characterization of a Small Molecule Inhibitor of Fatty Acid Binding Proteins. Journal of Medicinal Chemistry, 2009;52(19):6024-6031). ...
2009 NOV 23 ... November 7, 2009 and Sunday, November 8, 2009 About DX-88 for HAE DX-88, a recombinant, small protein, was discovered utilizing Dyax's proprietary phage display technology and is ... by low or dysfunctional levels of C1 esterase inhibitor (C1-INH), a naturally occurring molecule that inhibits plasma kallikrein and other serine proteases in the blood. About Dyax Dyax ...
2009 NOV 23 ... (Exton, PA). The lead investigational compound in the portfolio is an inhalable smallmolecule fusion inhibitor, now called MDT-637. This highly potent compound has ...
2009 NOV 29 ... Anticancer Therapy, Antitumor Activity, Cancer, Hematology, Neuroblastoma, Oncology, Small Molecule Inhibitor, Treatment, Journal of the National Cancer Institute.This article was ...
2009 NOV 17 ... adhesion molecule-1 (ICAM-1) are prominent members of a mature IS, the effect of a small molecular inhibitor for LFA-1, BIRT377, was investigated. BIRT377 almost completely ...
2009 NOV 24 ... growth of fSMCs and mSMCs in ex vivo cultures and in Matrigel implants. Furthermore, two smallmolecule inhibitors of the PDGFR tyrosine kinase (i.e., imatinib and dasatinib) exerted ... States, Life Sciences, Leiomyoma, Imatinib, Antineoplastic, Protein Kinase Inhibitor, Dasatinib, Sprycel, Reproduction. This article was prepared by Life ...
2009 NOV 23 ... in ovarian cancer. "This study was designed to determine the effects of vandetanib, a small-molecule receptor tyrosine kinase inhibitor of vascular endothelial growth factor and ...
2009 NOV 23 ... "Chemotherapy for metastatic bladder cancer is rarely curative. The recently developed smallmolecule, lapatinib, a dual epidermal growth factor receptor (EGFR)/human epidermal ... factor receptor (EGFR)/human epidermal growth factor receptor-2 receptor tyrosine kinase inhibitor, might improve this situation," scientists writing in the journal Neoplasia report. ...
2009 NOV 16 ... control of outbreaks. Through high-throughput screening, we recently identified a novel small-molecule class that potently blocks activity of the measles virus (MeV) RNA-dependent ... of a paramyxovirus RdRp complex through interaction of a non-nucleoside small-molecule inhibitor with the L protein. Resistance mutations are located in regions of L that are fully ...
2009 NOV 16 ... Drug Therapy, Enzymes, Flaviviridae, Flavivirus, Luciferase, Public Health, Small Molecule Inhibitor, Treatment, Viral, Virology, Virus, Yellow Fever, Purdue University. This ...
2009 NOV 16 ... #C59) Targeting tumor cell glycolysis: Discovery and characterization of smallmolecule inhibitors of IPFK2 (Inducible 6-Phosphofructo-2-Kinase) will be presented on ... Data Presentations A phase 1 safety and pharmacokinetic (PK) study of PI3K/TORC1/TORC2 inhibitor, XL765 (SAR245409), in combination with erlotinib in patients (pts) with advanced solid ...
2009 NOV 23 ... the multiple mechanisms that allow CRPC tumors to grow. About TOK-001 TOK-001 is a smallmolecule, oral drug that disrupts the growth and survival of cancer cells by attacking ... ways to treat prostate cancer: as an androgen receptor antagonist, as a CYP17 lyase inhibitor and by decreasing overall androgen receptor levels in prostate cancer tumors. Androgen ...
2009 NOV 16 ... and up-regulated by extracellular signal-regulated kinase (ERK). Furthermore, by using a small inhibitory molecule targeting ERK we interrupted MCT-1 phosphorylation and stability. ... cells with distinct levels of MCT-1 protein displayed differential sensitivity to ERK inhibitor-induced apoptosis. Treatment with the ERK inhibitor showed marked in vivo antitumor ...
