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2009 SEP 28 ... a group of patients with meningioma recurring after standard treatments in all of whom somatostatin receptors were strongly expressed on meningioma cell surfaces. Twenty-nine patients with ... (EBRT) is usually given in such cases but is not always effective. We assessed peptide receptor radionuclide therapy (PRRT) using Y-90-DOTATOC in a group of patients with meningioma ...
2009 SEP 28 ... Japan, "In-111 (In-111)-labeled octreotide has been clinically used for imaging somatostatin receptor-positive tumors, and radiolabeled octreotide analogs for positron emission tomography ...
2009 NOV 16 ... on ACTH-secreting tumors are controversial. This study was aimed to determine whether somatostatin receptor (SSTR) subtype (1-5) and dopamine receptor type 2 (D2R) are differentially expressed in ...
2009 SEP 21 ... analogue Tyr(3)-octreotide, which has a high binding affinity for the SSTR2 receptor (somatostatin receptor subtype 2) expressed on tumor cells, is used clinically for the diagnosis and treatment ...
2009 NOV 9 ... were noted: (i) exendin-4 suppressed the increase in plasma glucose and inhibited somatostatin expression induced by STZ, (ii) reduction of insulin prevalence was inhibited, while ... the possible components of cellular mechanism triggered by exendin-4, a potent GLP-1 receptor agonist, in streptozotocin (STZ) induced diabetic mice pancreas." "BALB/c ...
2009 SEP 21 ... between 1992 and 2006 were reviewed. Patient's outcome and diagnostic accuracy of somatostatin receptor scintigraphy (SRS) and morphological imaging (MI) for detection of recurrences during ...
2009 SEP 28 ... "However, most pancreatic cancer cells are resistant to TRAIL therapy. Human somatostatin receptor gene 2 (hSSTr2) is lost in 90% of pancreatic carcinoma. Oncolytic viruses are able to ...
2009 NOV 2 ... (PRRT) with radiolabelled somatostatin analogues is a novel therapy for patients with somatostatin receptor-positive tumours. We determined the effects of PRRT with ...
2009 SEP 28 ... Retinal Angiogenesis in a Mouse Model of Oxygen-Induced Retinopathy: Involvement of the Somatostatin Receptor Subtype 2. Investigative Ophthalmology & Visual Science, 2009;50(8):3596-3606). ...
2009 SEP 28 ... colleagues, University of Basel. The researchers concluded: "As found for somatostatin receptor-targeting radiopeptides, GRP-based radioantagonists seem to be superior to radioagonists ...
2009 SEP 21 ... outcome. Resection of liver metastases, resection of small bowel primary, treatment with somatostatin analogue therapy and treatment with peptide receptor therapy were associated with ...
2009 NOV 2 ... SS14 on L-VGCCs was mediated through the pertussis-toxin-sensitive G-protein-dependent somatostatin receptor 2 (sst2). Activation of sst2 by SS14 further activated downstream signaling involving ...
2009 OCT 12 ... processes elicits systemic anti-inflammatory and analgesic effects. With the help of somatostatin receptor subtype 4 gene -deleted mice (sst(4)(-/-)), we provide here several lines of evidence ...
2009 NOV 9 ... targeting these receptors. Specifically, we examined the receptor expression of somatostatin-type-2 receptor, growth hormone-releasing hormone (GHRH) receptor or GHRH receptor ...
2009 SEP 14 ... According to a study from the United States, "Somatostatin receptor subtype 2A (sst2A) mediates many of the endocrine and neuronal actions of somatostatin ...
2009 NOV 2 ... of the striatal interneurons expressing the neurokinin-1 receptors (cholinergic and somatostatin) with the selective neurotoxin [Sar(9),Met(O(2))(11)] substance P-saporin. Next we ... Research findings, 'The neurokinin-1 receptor modulates the methamphetamine-induced striatal apoptosis and nitric oxide formation in ...
2009 OCT 12 ... and colleagues published their study in Endocrine Pathology (Vasculopathic Changes, a Somatostatin-Producing Neuroendocrine Carcinoma and a Jejunal Gastrointestinal Stromal Tumor in a ... invasion. The GIST did not display mutations in c-kit or platelet-derived growth factor receptor genes. The novel finding in this case was the presence of several vessels in the ...
2009 NOV 16 ... 2009." "First published August 25, 2009; doi: 10.1152/ajpendo.00292.2009.-Somatostatin receptors (SSTR1-5) mediate antiproliferative effects. In C6 rat glioma cells, ... with selective agonists for SSTR1, -2, and -5 (BIM-23745, BIM-23120, BIM-23206) or receptor biselective compounds (SSTR1 and -2, BIM-23704; and SSTR2 and -5, BIM-23190). Nude mice ...
