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2009 NOV 24 ... between genetic variation in the GDF5 region and radiographic osteoarthritis (ROA) susceptibility, height, bone size parameters and fracture risk in a large population-based cohort of ... "A polymorphism ( rs143383; T to C) near the GDF5 gene has been associated with height and osteoarthritis (OA), but debate exists about whether ...
2009 NOV 24 ... junction mutation of PVRL1. Our results suggest that PVRL1 may play a minor role in susceptibility to the occurrence of nsCL/P in some Caucasian populations, and that variation involving ... their study in Genetic Testing and Molecular Biomarkers (Mutation Analysis of the PVRL1 Gene in Caucasians with Nonsyndromic Cleft Lip/Palate. Genetic Testing and Molecular ...
2009 NOV 28 ... According to recent research from Marburg, Germany, "In the last years, several susceptibility genes for psychiatric disorders have been identified, among others G72 (also named ... acid oxidase activator, DAOA). Typically, the high-risk variant of a vulnerability gene is associated with decreased cognitive functions already in healthy ...
2009 NOV 24 ... SNPs of IRF5 was observed using regression analysis. These data confirm STAT4 as a susceptibility gene for SLE and suggest the presence of at least two functional variants affecting levels of ...
2009 NOV 23 ... cultures of clinical S. epidermidis isolates was evaluated." "Initially, susceptibility to cinnamon oil in planktonic cultures was compared to the commonly used antimicrobial ... effect of sub-MIC concentrations of cinnamon oil on expression of the biofilm-related gene, icaA. Cinnamon oil showed antimicrobial activity against both planktonic and biofilm ...
2009 NOV 23 ... We then tested whether human genetic polymorphisms in the CD39 gene might influence susceptibility to Crohn's disease. We induced colitis in mice using Dextran Sodium Sulfate (DSS). ...
2009 NOV 23 ... complications result from complex interactions between therapeutic exposures and genetic susceptibility. This review is designed to increase general clinician awareness of the ongoing efforts ... complications. Most studies have relied on a biologically plausible candidate gene approach to evaluate genetic susceptibility. This has resulted in the identification of ...
2009 NOV 23 ... between specific single nucleotide polymorphisms of transcobalamin II (TCII) gene and susceptibility to both asbestos and pernetrexed," researchers in Athens, Greece report. ...
2009 NOV 23 ... GAD analysis revealed that schizophrenia was an over-represented disease class, with 42 susceptibility genes included (p < 0.001, fold enrichment = 1.66, FDR = 1.5%). Among the 42 genes, ... PFC. We then performed functional annotation analyses of age-associated genes using the Gene Ontology and the Genetic Association Database (GAD). We found robust age-dependent ...
2009 NOV 23 ... "These results suggest that TNFR2 +587 gene polymorphism may be associated with susceptibility to OLP." Fujita and colleagues published their study in International ...
2009 NOV 23 ... "The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we conducted a ...
2009 NOV 23 ... dismutase (sodB) gene expression (sodB Delta sodC) were constructed and evaluated for susceptibility to ROS and RNS in gamma interferon (IFN-gamma)-activated macrophages and a mouse model ...
2009 NOV 23 ... identified as methicillin susceptible on the basis of results of testing for cefoxitin susceptibility because cefoxitin may not induce the mecA gene as reliably in S pseudintermedius as it ...
2009 NOV 24 ... "This result suggests that the rs11187033 at IDE gene might contribute to MetS susceptibility in Chinese elders." Lu and colleagues published the results of their ...
2009 NOV 23 ... "Inactivating mutations in the human FUT2 gene are associated with reduced susceptibility to Helicobacter pylori infection. H. pylori infects over half the world's population ...
2009 NOV 23 ... efflux pump expression. We investigated the molecular mechanisms of aminoglycoside susceptibility exhibited by Thai strains 708a, 2188a, and 3799a." "qRT-PCR revealed ... respectively). This deletion not only removed the amrAB-oprA operon, but also the entire gene clusters for malleobactin and cobalamin synthesis. Other genes deleted included the ...
2009 NOV 23 ... we sought to determine the significance of MSR1 polymorphisms in its encoding gene in susceptibility to atherosclerosis. We genotyped three polymorphic sites in the MSR1 gene including a ...
2009 NOV 23 ... interleukin (IL)-12/23-and interferon (IFN)-gamma-mediated immunity can cause increased susceptibility to intracellular microbes. Among these defects, a mutation of the gene encoding the ...
2009 NOV 24 ... States, "Sexually dimorphic brain nuclei underlie gender-specific neural functions and susceptibility to disease, but the developmental basis of dimorphisms is poorly understood. In these ... key members of this pathway were expressed exclusively in GABAergic neurons. One gene in particular, TNF receptor-associated factor 2 (TRAF2)-inhibiting protein (trip), was ...
2009 NOV 23 ... (OR = 4.99, P = 0.001). In tobacco users, AA genotype showed significantly increased susceptibility to cervical cancer (OR = 5.08, P = 0.010)," wrote R. Gangwar and colleagues. ... A single nucleotide polymorphism located in the first intron of the human IFN-gamma gene can influence the secretion of cytokine." "Therefore, we aimed to ...
