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2009 OCT 5 ... "Small metastatic lung tumor sections obtained after tail-vein injection of a syngeneic breast cancer cell line in the nude mice were labeled with antibodies against ... against endothelial cell markers. Immunofluorescence showed the incorporation and mixed growth of CD31-, Tie-2-, and CD105-positive endothelial cells in tumors with radii less than ...
2009 JUL 13 ... are hormone-dependent (HD), metastatic, express both ER and PR, and are maintained by syngeneic transplants. The model has been further refined to include mammary carcinomas that ... receptors (PR). By contrast, most of the spontaneous, chemically or mouse mammary tumor virus induced tumors, as well as tumors arising in genetically modified mice do not ... highlighting the role of PR as a trigger of key signaling pathways mediating tumor growth," wrote C. Lanari and colleagues, . The researchers concluded: "In ...
2009 NOV 9 ... (EMT) following treatment with transforming growth factor-beta or injection into syngeneic mice. This transition was entirely dependent on the microRNA (miR)-200 family, which ... "Metastatic disease is a primary cause of cancer-related death, and factors governing tumor cell metastasis have not been fully elucidated. Here, we address this question by using ...
2009 OCT 19 ... of stromal SPARC, we evaluated subcutaneous tumorgrowth of TRAMP cell lines in syngeneic SP(+/+) and SP(-/-) mice. Enhanced growth, decreased stromal collagen and increased ...
2009 NOV 23 ... squamous cell carcinoma, and 3LL Lewis lung cancer), all of which grew in the dermis of syngeneic mouse skin. When DMDP-liposomes were injected into four spots to surround the tumor on ... survival in the case of various types of tumors. To evaluate the role of TAMs in tumor growth, we here specifically eliminated TAMs by in vivo application of dichloromethylene ...
2009 JUL 20 ... also reversed the alterations of lymphoma growth induced by chronic stress in syngeneic mice bearing tumors as well as Interleukin-2 production and specific cytotoxic response ... reported that chronic restraint stress impairs T-cell mediated immunity and enhances tumor growth in mice. To study the participation of these hormones on the stress-induced ...
2009 SEP 21 ... similar to that seen in human breast cancer. Mammary tumors, induced by inoculation of syngeneic BALB/c mice with BJMC3879 cells, were subsequently treated with panaxanthone at 0, ... the main component of panaxanthone, on BJMC3879 cells. In the in vivo study, tumor volumes were significantly suppressed in mice treated with 2,500 and 5,000 ppm ... According to recent research from Osaka, Japan, "The antitumor growth and antimetastatic activity of panaxanthone (approximately 80% alpha-mangostin and 20% ...
2009 AUG 17 ... induction. Karyotyping detected multiple acquired chromosomal aberrations, and syngeneic transplantation into the brain of adult rats resulted in malignant tumor formation. ... as well as an undifferentiated phenotype. Deficient downregulation of platelet-derived growth factor (PDGF) receptor alpha was identified as candidate mechanism for tumor cell ...
2009 JUL 20 ... 100 mu g daily, significantly inhibited tumorgrowth in the murine HGF-dependent CT-26 syngeneictumor model (P <0.002). Human and murine c-Met-Fc seemed to be well-tolerated in ...
2009 OCT 12 ... inhibited the metastatic ability of murine Lewis lung carcinoma (LLC) cells in syngeneic C57BL/6 mice caused by the decline of serum vascular endothelial growth factor (VEGF) ... Journal of Agricultural and Food Chemistry (The Monascus Metabolite Monacolin K Reduces Tumor Progression and Metastasis of Lewis Lung Carcinoma Cells. Journal of Agricultural and ...
2009 AUG 17 ... steatosis, coupled with a splenic injection model of experimental liver metastasis using syngeneic MC38 colon cancer cells, resulted in an increased number of secondary tumor nodules and ... early stages of uncomplicated steatosis provide a permissive microenvironment for the growth of colon cancer cells that are metastatic to the liver. High fat diet-induced steatosis, ...
2009 OCT 19 ... with anti-CTLA-4 antibody. TSA mouse breast carcinoma cells were injected s.c. into Syngeneic mice at two separate sites, defined as a ''primary'' site that was irradiated and a ... combination or not with 9H10 monoclonal antibody against CTLA-4. Mice were followed for tumorgrowth/regression. Similar experiments were conducted in the MCA38 mouse colon carcinoma ...
2009 SEP 21 ... expansion of telomerase-specific T cells for adoptive cell transfer and their use in a syngeneic pancreatic carcinoma mouse model." "Telomerase-specific T cells were ... T cells without losing their function after adoptive cell transfer. Significantly slower tumorgrowth rate and less metastasis were observed after adoptively transferring telomerase ...
2009 JUL 13 ... NK4 gene therapy inhibits tumorgrowth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models,' new data in cancer gene therapy. "Hepatocyte growth factor (HGF) ...
2009 OCT 5 ... concentration of 50 mg/kg body weight significantly inhibited in vivo the growth of a syngeneic hepatocellular carcinoma in Balb/c mice," wrote G. Viola and colleagues, University of ... of azolotetrazinones endowed with a high, remarkable antiproliferative activity in human tumor cultured cells. They hold the deaza skeleton of the antitumor drug temozolomide, ...
2009 AUG 3 ... in vitro." "Here, we show bortezomib augments the antitumor effects of syngeneic NK-cell infusions in tumor-bearing animals; this effect is further enhanced in ... established tumors showed treatment with bortezomib and syngeneic NK cells reduced tumor growth and prolonged survival compared with controls receiving bortezomib or NK cells alone. In ...
2009 JUL 20 ... effect on the viability of primary cells and drastically reduced B16 melanoma growth in syngeneic C57BL/6 mice. In addition, at the equivalent of the 100% lethal dose of Saq, Saq-NO ... (Saq-NO) significantly reduced the viability of a wide spectrum of human and rodent tumor cell lines at significantly lower concentration than the unmodified drug. In contrast to ...
2009 NOV 23 ... efficacy of sequential treatment with paclitaxel and alpha-TEA was tested in the BALB/c syngeneic 66cl-4-GFP mammary cancer model." "Both agents were formulated into ... chroman-6-yloxyacetic acid (a-TEA) is an analog of vitamin E that inhibits primary tumorgrowth and the incidence of lymphatic and pulmonary metastases in preclinical animal ...
2009 NOV 23 ... levels of class I major histocompatibility complex (MHC) antigens. While radiation and syngeneic bone marrow transplantation (BMT) reduced tumorgrowth (P < 0.001), allogeneic BMT ...
2009 NOV 16 ... cells in vitro. Through I-123-scintigraphy and ex vivo gamma counting Neuro2A tumors in syngeneic A/J mice were shown to accumulate 8% to 13% ID/g I-123 with a biological half-life of 13 ... recently reported the significant therapeutic efficacy of radioiodine therapy in various tumor mouse models following transcriptionally targeted sodium iodide symporter (NIS) gene ... followed by I-131 application (55.5 MBq) resulted in a significant delay in tumor growth associated with markedly improved survival," wrote K. Klutz and colleagues. ...
