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2009 JUL 27 ... According to recent research published in the Journal of Immunology, "The E mu-TCL1 transgenic mouse spontaneously develops a CD5(+) B cell lymphoproliferative disorder ...
2009 MAR 23 ... Fresh data on life sciences are presented in the report 'The Tcl1 oncogene defines secondary hair germ cells differentiation at catagen-telogen transition ...
2009 JAN 19 ... Klf6 regulates ESC proliferation by promoting phosphorylation of Akt1 via induction of Tcl1," wrote M. Ema and colleagues, University of Tsukuba.
The researchers ...
2009 MAY 4 ... human CLL," researchers in Salzburg, Austria report.
"We used the TCL1 transgenic mouse model to directly target PKC beta in the development of murine CLL. ...
2009 JUN 15 ... through interactions with a number of signalling pathways, including PI3K/AKT, ras, TCL1, and BCR/ABL. Many haematological malignancies have aberrant activation of the mTOR and ...
2009 OCT 12 ... being aggressively investigated as potential therapeutic targets. Here we use the E mu-TCL1 transgenic mouse model of chronic lymphocytic leukemia (CLL) to determine the timing and ...
2009 FEB 16 ... B-cell non-Hodgkin's lymphoma has identified increased T-cell leukemia/lymphoma 1A (TCL1) expression in multiple lymphoma types and cases, and has enabled the investigation of ...
2009 FEB 16 ... is the most common human leukemia. Deregulation of the T cell leukemia/lymphoma 1 (TCL1) oncogene in mouse B cells causes a CD5-positive leukemia similar to aggressive human ...
2009 MAY 11 ... B-cell leukemogenesis, we examined the expression of Wnt/Fzd pathway genes in the E mu-TCL1 mouse model of chronic lymphocytic leukemia. We find that, in the course of ...
2009 JUN 15 ... by cancer, we examined T-cell function in the chronic lymphocytic leukemia (CLL) E mu-TCL1 transgenic mouse model. With development of leukemia, E mu...
2008 SEP 29 ... interfering RNA, which eventually results in cell apoptosis. The signal pathway Oct4/Tcl1/Akt1 has been observed to be involved in this event. The repression of Oct4 reduces Tell ...
2008 NOV 10 ... on matrigel. Term primary trophoblasts or immortalized third trimester extravillous TCL1 trophoblasts not only fail to respond to signals from endothelial cells but also inhibit ...
2008 OCT 27 ... high copy numbers of gamma retroviral vectors encoding the potent T-cell oncogenes LMO2, TCL1, or Delta TrkA, a constitutively active mutant of TrkA. After transplantation into RAG-1 ...
2008 APR 7 ... of the ATM gene and chromosomal re-arrangements leading to an overexpression of MTCP1/TCL1 oncoproteins. These alterations are present at the earliest stage of malignant ...
2008 NOV 11 ... we investigated the gene expression profile during matrigel-induced tube formation in TCL1 cells, a human immortalized EVT cell line, and HUV-EC-C, human umbilical vessel ...
