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2009 NOV 10 ... has taken place by a process during which an entire chromosome is inserted by its telomeres into a break in the centromeric region of another chromosome. The original ...
2009 NOV 11 ... Sir2p, Sir3p, and Sir4p are structural components of heterochromatin found at telomeres and the silent mating-type loci," scientists in the United States report. ...
2009 NOV 10 ... cells in the peripheral blood. We also observed that the peritoneal T cells had altered telomeres; some cells had ultrashort telomeres, suggesting a ...
2009 NOV 24 ... "Here, we address the role of the MRN (Mre11/Rad50/Nbs1) complex in the response to telomeres rendered dysfunctional by deletion of the shelterin component TRF2. Using conditional ...
2009 OCT 26 ... telomere maintenance, and its kinase activity is required. Tel1p associates with telomeres in vivo, is enriched at short telomeres, and enhances ...
2009 NOV 24 ... cells was the same as that in Tert(Delta/Delta) alone." "Although telomeres from late-passage Mre11(ATLD1/ATLD1) Tert(Delta/Delta) cells were as short as those from ...
2009 NOV 23 ... of Georgia. The researchers concluded: "This indicates that K. lactis telomeres have preferred termination points within the 25-bp telomeric repeat." Wang ...
2009 NOV 2 ... failure (aplastic anaemia and dyskeratosis congenita) and familial pulmonary fibrosis. Telomeres are constituted of double-stranded tandem TTAGGG repeats followed by a 3' G-rich ...
2009 NOV 16 ... by two known mechanisms, the activation of telomerase or alternative lengthening of telomeres (ALT). The molecular mechanisms regulating the ALT phenotype are poorly understood and ...
2009 OCT 27 ... "TRF2, a component of the shelterin complex, functions to protect telomeres. TRF2 contains an N-terminal basic domain rich in glycines and arginines, similar to the ...
2009 NOV 23 ... Research findings, 'The alternative lengthening of telomeres phenotype in breast carcinoma is associated with HER-2 overexpression,' are discussed ...
2009 NOV 16 ... and death from cardiovascular disease and cancer, but determinants of shortened telomeres, a molecular feature of biological aging, are still largely unidentified. Traffic ...
2009 NOV 1 ... of Trf4p. In addition, we show that disruption of trf4 causes severe shortening of telomeres suggesting that TRF4 functions in the maintenance of telomere length. Finally, our study ...
2009 NOV 9 ... are specialized PML bodies found exclusively in telomerase-negative tumors in which telomeres are maintained by recombination-based alternative (ALT) mechanisms," scientists writing ...
2009 NOV 13 ... to longer telomere lengths within oral mucosal fibroblasts. The presence of these longer telomeres was independent of telomerase expression, since both oral oral mucosal fibroblasts and ...
2009 NOV 23 ... that is responsible for extending and preserving the end of the chromosomes (telomeres)." "Telomerase plays a key role in regulating the lifespan of mammalian ...
2009 NOV 23 ... is a well defined lymphoid neoplasm genetically characterized by the t(11;14)(q13;q32). Telomeres play an essential role in preserving chromosomal integrity and genomic stability; their ...
2009 NOV 23 ... amplification. GRN163L was effective in inhibiting telomerase activity and shortening telomeres in HER2-positive breast cancer cells. We show that GRN163L acts synergistically with ...
2009 NOV 2 ... factor 1 (TERF1, referred to hereafter as TRF1) is a component of mammalian telomeres whose role in telomere biology and disease has remained elusive. Here, we report on ...
