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2009 JUL 27 ... South Korea, "GTP cyclohydrolase I (GTPCH) is a key enzyme in the de novo synthesis of tetrahydrobiopterin. Previously, the Drosophila melanogaster GTPCH gene has been shown to be expressed from ...
2009 AUG 31 ... triphosphate (GTP) cyclohydrolase (GCH1, the key enzyme in de novo synthesis of tetrahydrobiopterin, a cofactor for NO production), and ornithine decarboxylase (ODC1) in uterine endometria ...
2009 NOV 16 ... domain ( FAD and FMN) and a catalytic heme oxygenase domain (P450-type heme and tetrahydrobiopterin). Bacterial NOSs, while much less studied, were previously identified as only containing ...
2009 SEP 14 ... of catalytic decoupling of NOS that could be reversed by supplementation with tetrahydrobiopterin (BH4)," wrote D. Steinritz and colleagues. The researchers concluded: ...
2009 NOV 17 ... According to recent research published in the journal Annals of Neurology, "Tetrahydrobiopterin (BH4) deficiency is a cause of dystonia at birth. We hypothesized that BH4 is a ...
2009 AUG 18 ... and colleagues published their study in Current Genetics (PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite ...
2009 AUG 3 ... "Defects in the metabolism or regeneration of tetrahydrobiopterin (BH4) were initially discovered in patients with hyperphenylalaninaemia who had ...
2009 JUL 27 ... is uncoupled in streptozotocin (STZ)-induced type 1 diabetes because of reduced cofactor tetrahydrobiopterin (BH4). We tested the hypothesis that overexpression of GTP cyclohydrolase I (GTPCH I), ...
2009 NOV 23 ... GroEL/GroES chaperone effect and slightly positive effect of the (6R)-l-erythro-5,6,7,8-tetrahydrobiopterin (BH4) on the stabilization of the protein structure. Our findings were in accordance ...
2009 SEP 15 ... is insensitive to changes in concentrations of the substrate arginine, or the cofactor tetrahydrobiopterin. Mechanistic analysis suggests that KLYP956 binds the oxygenase domain in the vicinity ...
2009 AUG 17 ... "Almost all of these folB-deficient genomes contain an unusual paralog of the tetrahydrobiopterin synthesis enzyme 6-pyruvoyltetrahydropterin synthase (PTPS) in which a glutamate residue ...
2009 OCT 5 ... Cofactor, Cyclohydrolase, Dietary Supplement, Enzyme Research, Hypertension, Synthase, Tetrahydrobiopterin, University of Oklahoma. This article was prepared by Cardiovascular Week ...
2009 JUL 27 ... NOS inhibition by corrins was rapid and not reversed by dialysis with L-arginine or tetrahydrobiopterin. Molecular modeling indicated that corrins could access the unusually large heme- and ...
2009 SEP 21 ... enhanced nitric oxide (NO) generation. However, its effect on the NO synthase cofactor, tetrahydrobiopterin are less clear." "Cellular...
2009 OCT 19 ... (1970-May 2009), and Cochrane database (2008) for the following key words: sapropterin, tetrahydrobiopterin, phenylketonurias, and phenylalanine." "AND DATA EXTRACTION: ...
2009 OCT 12 ... According to recent research from Heidelberg, Germany, "Tetrahydrobiopterin (BH4) cofactor loading is a standard procedure to differentiate defects of BH4 ...
2009 AUG 31 ... diet augments endothelial dysfunction via elevated oxidative stress and reduced tetrahydrobiopterin in Ins2(Akita) mice, an autosomal dominant mutant type 1 diabetic model' new findings ...
