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2009 OCT 12 ... According to recent research from Barcelona, Spain, "Thrombospondin-1 (TSP-1.) is a potent inhibitor of angiogenesis and an activator of tissue transforming ...
2009 OCT 5 ... cells transfected with control and PRMT6 small interfering RNAs. We identified thrombospondin-1 (TSP-1), a potent natural inhibitor of angiogenesis, as a transcriptional repression ...
2009 NOV 23 -- According to a study from the United States, "Stroke is a leading cause of death and disability. The only therapy available is recombinant tissue plasminogen activator, but side effects limit its use." "Platelets play a crucial......
2009 NOV 16 ... inhibitory receptor upregulates the expression of the secreted angioinhibitory factor thrombospondin-1 (TSP-1), as demonstrated in exocrine BxPC-3 and endocrine BON pancreatic cancer cells," ...
2009 OCT 5 -- Current study results from the report, 'Analysing the role of endogenous matrix molecules in the development of osteoarthritis,' have been published. According to recent research from the United Kingdom, "Osteoarthritis (OA) is the most common......
2009 NOV 2 -- According to recent research from Hannover, Germany, "Aggrecan cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 5 (ADAMTS-5) is crucial for the breakdown of cartilage matrix during osteoarthritis(1,2), a......
2009 NOV 9 -- According to a study from the United States, "In pregnancy, it may be difficult to differentiate the syndrome of hemolysis, elevated liver enzymes, and low platelets from thrombotic thrombocytopenia purpura. Severely depressed (<5%) or......
2009 NOV 2 ... exposed to radiation. In mouse experiments, they found that blocking a molecule called thrombospondin-1 from binding to its cell surface receptor, called CD47, affords normal tissues nearly ...
Subject: University of Pittsburgh Schools of the Health Sciences
2009 OCT 12 -- According to recent research from Seoul, South Korea, "Fabry disease is a lysosomal storage disease caused by a deficiency of alpha-galactosidase A, which results in aberrant glycosphingolipid metabolism and accumulation of globotriaosylceramide......
2009 NOV 16 -- "The Plasmodium falciparum circumsporozoite protein (CSP) is critical for sporozoite function and invasion of hepatocytes. Given its critical nature, a phase III human CSP malaria vaccine trial is ongoing," scientists in the United States......
2009 NOV 23 -- According to recent research from Barcelona, Spain, "Our aim was to examine whether an acute fat load could induce changes in the expression of insulin sensitivity-related genes in human peripheral blood mononuclear cells. Selection of candidate......
2009 OCT 5 -- Fresh data on angiogenesis are presented in the report 'c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma.' According to a study from......
2009 SEP 28 -- "Ocular neovascularization is the primary cause of blindness in a wide range of prevalent ocular diseases including proliferative diabetic retinopathy, exudative age-related macular degeneration, and retinopathy of prematurity, among others.......
2009 NOV 16 ... were examined in the experimental group. Vascular endothelial growth factor (VEGF), thrombospondin-1 (TSP1), and CD31 were examined using Western blot analysis and immunohistochemistry. The ...
2009 SEP 28 -- Current study results from the report, 'Sulfasalazine blocks the release of proteoglycan and collagen from cytokine stimulated cartilage and down-regulates metalloproteinases,' have been published. "To investigate the effect of SSZ on the......
2009 OCT 12 -- According to a study from the United States, "Bone metastasis is mediated by complex interactions between tumor cells and resident stromal cells in the bone microenvironment. The functions of metalloproteinases in organ-specific metastasis......
2009 NOV 1 -- A Duke University Medical Center researcher who spent years looking for the signals that prompt the brain to form new connections between neurons has found one that may explain precisely how a well-known drug for epilepsy and pain actually works.......
2009 OCT 12 ... to down-regulation of c-Myc and elevated levels of another key antiangiogenic protein, thrombospondin-1, reinforcing its antitumor and antiangiogenic effects. Further evidence is provided for ...
