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2009 OCT 5 ... efficacy was inferior in patients with increased beta 2-microglobulin (beta 2-MG) and thymidine kinase (TK). In multivariate analysis of clinical and biologic variables, age, performance ...
2009 NOV 9 ... potentially responsible for PCV resistance. A single nucleotide deletion in the thymidine kinase (TK) gene was identified. To confirm its role in PCV resistance, several TK recombinants ...
2009 NOV 2 ... transduced with a retroviral vector encoding for the sr39 mutant herpes simplex virus 1 thymidine kinase (sr39HSV1-tk) reporter gene can be detected after intravenous infusion in discrete ...
2009 SEP 28 ... strategy with adenoviruses (Ad) expressing Flt3L (Ad-Flt3L) and thymidine kinase (Ad-TK) to treat glioblastoma (GBM), we tested the hypothesis that Ad-TK+GCV would be ...
2009 NOV 23 ... replicative adenovirus." "Incorporation of herpes simplex virus thymidine kinase (HSV-tk) and monomeric red fluorescent protein 1 (mRFP1) into the viral capsid and its ...
2009 NOV 16 ... AZT (3'-azido-3'-deoxythymidine; known as zidovudine) is caused by inhibition of thymidine kinase 2 of the salvage pathway and subsequent TTP pool depletion." "The extent ...
2009 OCT 5 ... cells, using a gene encoding a fusion protein of dihydrofolate reductase (DHFR) and thymidine kinase (TK). DHFR confers resistance to methotrexate (MTX) and TK confers sensitivity to ...
2009 NOV 9 ... and colleagues. The researchers concluded: "HSV-1/L-2/RHp-ACV herpes virus thymidine kinase is shortened from the C-terminus by 100 amino acid residues in length." ...
2009 NOV 16 ... activity of VEGF." "Cell proliferation was evaluated using [H-3]-thymidine incorporation and 3,(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide ... published their study in Investigative Ophthalmology & Visual Science (FAK and p38-MAP Kinase-Dependent Activation of Apoptosis and Caspase-3 in Retinal Endothelial Cells by alpha ...
2009 NOV 16 ... States report. "Proliferation and migration rates were determined by [H-3]-thymidine incorporation and scratch wound healing assay, respectively. EGF induced increases in ... migration is dependent on the duration and magnitude of extracellular signal-regulated kinase (Erk)1/2 activation. Western blot analysis evaluated the phosphorylation status of ...
2009 NOV 16 ... cells into the tumor microenvironment, and an Ad expressing herpes simplex virus-1-thymidine kinase (TK), which kills proliferating tumor cells in the presence of ganciclovir. This ...
2009 NOV 16 ... S. aureus is antagonized by thymidine through uptake and conversion to thymidylate by thymidine kinase." "Unlike with humans, for whom thymidine levels are low, thymidine ...
2009 OCT 12 ... uridine homeostasis. C. elegans UP homologous protein (UPP-1) exhibited both uridine and thymidine phosphorylase activity in vitro. Knockdown of other pyrimidine biosynthesis enzyme ... of other pyrimidine biosynthesis enzyme homologs, such as uridine monophosphate kinase and uridine monophosphate synthetase, also resulted in 5-FU resistance. Uridine ...
2009 OCT 12 ... and showed a high inducible response to exogenous H2O2. Transient expression of the thymidine kinase (TK) gene driven by the chimeric promoter, followed by gancyclovir (GCV) administration, ...
2009 OCT 5 ... diagnosis despite intensive therapy. The aim of this study was to investigate the serum thymidine kinase 1 (TK1) concentration in Chinese patients with CLL and its correlation with ...
2009 NOV 16 ... related signal cascades in this study. BMP-4 significantly increased the level of [H-3]-thymidine incorporation in time- (>= 8 hours) and dose-( >= 10 ng/ml) dependent manners. ... activation and cyclin D1 expression were attenuated by phosphatidyl inositol 3-kinase (PI3K) siRNA and Akt inhibitor. Additionally, downregulation of Smad4, Wnt1, and PI3K ...
2009 SEP 21 ... after tumor resection and short incubation time (0-120 min) with [methyl-H-3]-thymidine," researchers in Stockholm, Sweden report. "A 9-77% inhibition of DNA ... "The effect of genistein, a protein tyrosine kinase and topoisomerase II inhibitor, on the DNA synthesis rate was studied in 21 human glioma ...
2009 SEP 28 ... the existence of other important 5' sequences. Induction disappears if a minimal T81 thymidine kinase promoter replaces the ovine FSHB TATA box and 3' exon/intron. The study reported here ...
2009 OCT 19 ... kinase, when compared with 5HT alone. In addition, MVIC mitogenesis per H-3-thymidine ((3)HTdR) demonstrated a 5HT dose-dependent increase, with no effect of Fen alone. In ...
2009 SEP 28 ... a 6-fold higher activity for the NA and a 20-fold k(cat)/K-M preference for ddT over thymidine, an overall 10 000-fold change in substrate specificity. The contributions of individual ... (dNKs). We herein report the directed evolution and characterization of an orthogonal NA kinase for 3'-deoxythymidine (ddT), using a new FACS-based screening protocol in combination ...
