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2009 JUN 2 ... single run is described. The five specific probe substrates of caffeine, chlorzoxazone, tolbutamide, metoprolol and midazolam, together with the internal standard diazepam, were extracted ...
2009 NOV 23 ... (Leu/Gln), but not the secretion stimulated by depolarizing agents such as KCl and tolbutamide, or Ca2+ channel opener Bay K8644. Genistein at a concentration of 50 mc M showed a ...
2009 NOV 16 ... he discovered diabetogenic mutant SUR1/KIR6.2 channels. Based on his analysis of the tolbutamide-sensitivity of ND-ABCC8/KCNJ11 recombinants, Babenko predicted which patients with ...
2009 FEB 2 ... that single L cells are electrically excitable and glucose responsive. Sensitivity to tolbutamide and low-millimolar concentrations of glucose and alpha-methylglucopyranoside, assessed ...
2009 FEB 9 ... expression is additionally induced by treatment of MIN6 pancreatic beta-cells with tolbutamide, a compound that triggers a closure of ATP-dependent potassium channels, K(ATP), in the ...
2009 AUG 31 ... Somatostatin secretion from human islets was stimulated by glucose and tolbutamide and inhibited by diazoxide. Human delta cells generated bursting or sporadic electrical ...
2009 MAY 18 ... was greatly increased than that in normal tissues. Treatment of glioma cells with tolbutamide, K(ATP) channels inhibitor, suppressed the proliferation of glioma cells and blocked ...
2009 AUG 3 ... unknown." "In 130 volunteers, CYP2C9 activity was measured in vivo using tolbutamide as a probe drug. Tolbutamide was administered orally, ...
2009 JUL 13 ... after oral and intravenous glucose challenges (P < 0.01) but not after injection of tolbutamide. In elderly twins, the G-allele associated with hepatic insulin resistance (P = 0.017). ...
2009 SEP 7 ... to the K-ATP channel opener diazoxide, and to the selective blockers glibenclamide and tolbutamide, did not differ between groups. In large neurons, selective inhibition of whole-cell ...
2009 AUG 24 ... and an increase in whole-cell K-ATP currents, explaining the diabetes of the patient. Tolbutamide block was only slightly reduced in the simulated heterozygous state, suggesting that the ...
2009 MAY 4 ... substrates: celecoxib, diclofenac, S-flurbiprofen, losartan, S-phenprocoumon, phenytoin, tolbutamide, torsemide, and S-warfarin. These predicted values, either using the intrinsic clearance ...
2009 FEB 16 ... P450 isoforms 1A2 (CYP1A2) and 2C9 (CYP2C9). Probe substrates, phenacetin (CYP1A2), and tolbutamide (CYP2C9) were incubated with human liver microsomes and the metabolites were analyzed by ...
2009 MAR 2 ... in pancreatic beta cells to inhibition by ATP or glucose. In contrast, the sulfonylurea tolbutamide, a specific blocker of K-ATP channels, closed K-ATP channels, elevated intracellular ...
2009 NOV 16 ... In contrast, activity of CYP2A6 (p = 0.001) and CYP2C9 (diclofenac, p = 0.0001; tolbutamide, p = 0.004) was significantly increased with NAFLD progression. Increased expression of ...
2009 FEB 23 ... partially mimicked by alpha-methylglucopyranoside, suggesting the involvement of SGLT1. Tolbutamide triggered secretion under basal conditions, whereas diazoxide suppressed responses in ...
2009 MAR 30 ... of the encapsulated pseudoislets was restored Oil Stimulation with the sulfonylurea drug tolbutamide. Our results indicate that the reason for the attenuated first phase of release is the ...
2009 JAN 26 ... on [Ca2+]c and insulin secretion. Kir6.2KO islets were insensitive to diazoxide and tolbutamide. In fresh adult Kir6.2KO islets, basal [Ca2+]c and insulin secretion were marginally ...
2009 SEP 1 ... and in vivo in mice lacking Epac2, and the glucose-lowering effect of the sulfonylurea tolbutamide was decreased in these mice. Epac2 thus contributes to the effect of sulfonylureas to ...
2009 JUL 28 ... calculated from a frequent sampling intravenous glucose tolerance test (FSIGT) with tolbutamide (n = 74) or from the homeostasis model assessment of insulin resistance (HOMA-IR) (n = ...
