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2009 NOV 9 ... M-1(2+) and M-2(2+), we individually mutated each of these acidic amino acid residues in topoisomerase I lot to either cysteine or alanine. Mutant enzymes displayed a marked loss of catalytic ...
2009 NOV 17 ... "Naphthoquinones have been studied extensively due to their activity as topoisomerase inhibitors. These enzymes are critical to DNA replication in cells," scientists in ...
2009 NOV 9 ... Enzymes, Enzymology, Molecular Modeling, Proteins, Proteomics, Therapy, Topoisomerase, Topoisomerase I, Treatment. This article was prepared by Biotech Business Week editors from ...
2009 NOV 17 ... of 1 (2-5 and 7-13) were synthesized based on docking studies and tested for their topoisomerase I and II alpha inhibitory activity," scientists in the United States report. ...
2009 NOV 16 ... a common sexually transmitted protozoan parasite, is increasing worldwide, and DNA topoisomerase II may provide a new target for anti-trichomonal drug development. In this study, T. ...
2009 NOV 23 ... M.D., both of Mersana, and provided an overview of XMT-1001 in the context of other topoisomerase I inhibitors conjugated to polymers or encapsulated in liposomes. XMT-1001 is ...
2009 NOV 23 ... to possess anticancer activities and to induce G(2)-M arrest through inhibiting topoisomerase II accompanied by Chk1 degradation. The current study was designed to precisely dissect ...
2009 NOV 30 ... According to recent research from New Delhi, India, "DNA gyrase is the only topoisomerase that can introduce negative supercoils into the DNA at the cost of ATP hydrolysis. Some ...
2009 NOV 23 ... convectable non-PEGylated liposomal formulation that can be used to encapsulate both the topoisomerase I inhibitor topotecan (topoCED ™) and paramagnetic gadodiamide (gadoCED ™), ...
2009 NOV 30 ... has been identified as the key enzyme in the metabolic activation of irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors," scientists in Harbin, ...
2009 NOV 16 ... the emergence of a highly mobile qnr genotype that, in the absence of mutation within topoisomerase genes, confers the nontypical quinolone resistance phenotype in S. enterica isolates. ...
2009 NOV 30 ... Oncology, Phosphodiesterase Inhibitor, Proteomics, Stem Cell Research, Therapy, Topoisomerase, Treatment This article was prepared by Biotech Business Week editors from ...
2009 NOV 24 ... nick at a single genomic site in Saccharomyces cerevisiae and thus mimics a stabilized topoisomerase I-DNA cleavage complex. We took advantage of a mutant Flp recombinase that can introduce a ...
2009 NOV 16 ... "Quinazoline-2,4-diones, such as PD 0305970, are new DNA gyrase and topoisomerase IV (topo IV) inhibitors with potent activity against gram-positive pathogens, including ...
2009 NOV 23 ... of AMA or sp100 status, there was an association of anticentromere B (CENP-B) and anti-topoisomerase antibodies (ATA) with higher alkaline phosphatase levels (p = 0.051 and p = 0.003, ...
2009 NOV 16 ... apoptosis induced by camptothecin or etoposide. Tunicamycin neither modified the topoisomerase levels nor inhibited the ATM activation caused by camptothecin and etoposide. The data ...
2009 NOV 9 ... to recent research from Nanjing, People's Republic of China, "A novel series of topoisomerase I (Top I) inhibitors were designed on the basis of camptothecin using scaffold ...
2009 NOV 23 ... According to recent research from the United States, "Human topoisomerase I binds DNA in a topology-dependent fashion with a strong preference for supercoiled DNAs ...
2009 NOV 1 ... Enzymology, Oncology, Pharmaceuticals, Proteins, Proteomics, Therapy, Topoisomerase, Topoisomerase I, Treatment, Women's Health, Medical University of Bialystok. This article ...
2009 NOV 16 ... plasmids arising as a result of DNA replication in Escherichia coli cells whose topoisomerase IV activity was inhibited," scientists writing in the journal Nucleic Acids Research ...
