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2009 AUG 18 ... phase II studies for Celgene. The first study compared Amrubicin to topotecan, a common and approved treatment for SCLC, in patients with extensive-disease SCLC who ...
2009 AUG 17 ... phase II studies for Celgene. The first study compared Amrubicin to topotecan, a common and approved treatment for SCLC, in patients with extensive-disease SCLC who ...
2009 SEP 14 ... site 5'-TG. We observed that the selection of 5'-TG by human topoisomerase I and topotecan depends to a large extent on the specific flanking sequences, and that the presence of a ...
2009 JUL 13 ... People's Republic of China, "The aim of this study was to investigate the effect of topotecan (TPT) on cancer cell migration. Growth inhibition of TPT was analyzed by MTT assay, and ...
2009 NOV 23 ... liposomal formulation that can be used to encapsulate both the topoisomerase I inhibitor topotecan (topoCED ™) and paramagnetic gadodiamide (gadoCED ™), providing an ideal ...
2009 SEP 14 ... activity of bevacizumab, either alone or in combination with the HIF-1 alpha inhibitor topotecan, was evaluated in U251-HRE xenografts. Tumor tissue was collected at the end of ...
2009 AUG 31 ... "This study was to investigate whether the topoisomerase (Top) I inhibitor topotecan and the Top II inhibitor etoposide could modulate the hypoxia-induced HIF-1 alpha ...
2009 SEP 14 ... According to recent research published in the journal Cancer Research, "Topotecan is a substrate of the ATP-binding cassette transporters P-glycoprotein (P-gp/MDR1) and ...
2009 SEP 28 ... "Preclinical studies have shown that the combination of topotecan and carboplatin is synergistic. To evaluate the schedule dependency of this interaction, ...
2009 NOV 16 ... activity assays. Additive growth inhibitory properties of miR-34a in combination with topotecan were determined by cell growth assay. miR-34a targets in RB cells were identified by ...
2009 JUL 6 ... According to recent research from Mexico, "Topotecan is active in advanced or metastatic cervical cancer even in patients who have received ...
2009 JUL 6 ... incorporated gemcitabine, methoxypolyethylene glycosylated liposomal doxorubicin, or topotecan compared with carboplatin and paclitaxel." "The primary end point was ...
2009 NOV 9 ... gemcitabine 1,000 mg/m2 day 1 and 8 plus Cis 50 mg/m(2) day 1 every 3 weeks (GC); or topotecan 0.75 mg/m(2) days 1, 2, and 3 plus Cis 50 mg/m(2) day 1 every 3 weeks (TC)." ...
2009 AUG 3 ... in Rome, Italy conducted a study "To evaluate the clinical benefit of a 3-day topotecan schedule in heavily pretreated recurrent ovarian cancer patients scheduled for ...
2009 JUL 20 ... developed resistance to daunorubicin, mitoxantrone, etoposide, vinblastine, paclitaxel, topotecan, gemcitabine, and 5-fluorouracil; as a result drug-induced apoptosis was impaired. ...
2009 AUG 31 ... with lesions up to 2 cm in diameter. She received eighteen weekly cycles of topotecan which led to a complete clinical response confirmed by CT. Forty-three months after the ...
2009 OCT 12 ... "To report a prospective, randomized, Phase II trial of radiotherapy with and without topotecan for the treatment of glioblastoma. Inclusion criteria were histology of glioblastoma, ...
2009 OCT 5 ... (r(2) = 0.846, P = 0.008), and %NGFR(+) vs daunorubicine (r(2) = 0.672, P = 0.047) and topotecan (r(2) = 0.792, P = 0.011). In contrast, inverse correlations were observed between: EGFR ...
2009 AUG 10 ... of liposomes and wheat germ agglutinin (WGA) was conjugated to the liposomes' surface. Topotecan was then loaded into the above liposomes. In vitro,...
2009 AUG 3 ... cells were 3.1-, 15-, 8-, and 6.8-fold resistant to becatecarin, mitoxantrone, SN-38 and topotecan, respectively. A549 Bec150 cells transported the ABCG2 substrates pheophorbide a, ...
