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2009 OCT 13 ... plasmid that lacks an active partitioning system. Plasmid stability is enhanced by a toxin-antitoxin (TA) system known as pas (plasmid addiction system) that is located within the ... within the replicon between the repB (primase) and the repA (helicase) and repC (DNA-binding) genes," scientists in Matieland, South Africa report. "The discovery of ...
2009 NOV 2 ... domains of whole rLF and rEF occur and have been identified; however, the major anthrax toxin-neutralizing humoral responses to these antigens are constituted by non-cross-reactive ... and Immunity, "Anthrax lethal and edema toxins (LeTx and EdTx, respectively) form by binding of lethal factor (LF) or edema factor (EF) to the pore-forming moiety protective antigen ...
2009 NOV 1 ... been extensively studied in the context of exposure to bacterial exotoxins. The alpha-toxin of Clostridium septicum is a beta-barrel pore-forming toxin and a potent cytotoxin; ... levels, and dramatically reduced levels of ATP. Finally, the immunostimulatory histone binding protein HMGB1 was found to be released from the nuclei of alpha-toxin-treated cells. ...
2009 OCT 19 ... was evaluated in vivo. Although no single mAb completely protected mice from toxin, they both could prolong time to death when challenged with 20 LD(50). (50% lethal ... a fully synthetic human antibody library. The 2 antibodies can effectively inhibit the binding between BoNT/A-Hc and differentiated PC-12 cells in vitro, and the neutralization was ...
2009 NOV 9 ... "Cry11Aa is the most active Bacillus thuringiensis israelensis toxin against Aedes aegypti larvae. Ae. aegypti alkaline phosphatase (ALP) was previously ... that specifically binds the midgut ALP-Cry11Aa receptor, An anti-ALP1 antibody inhibited binding to brush border membrane vesicles and toxicity of Cry11Aa in isolated cultured guts. Two ...
2009 NOV 24 ... and a B subunit (StxB), which is a nontoxic homopentameric protein responsible for toxin binding and internalization into target cells by interacting with the glycolipid, ...
2009 NOV 9 ... of Clostridium sordellii cause gangrenous myonecrosis in humans. The released lethal toxin (TcsL) and hemorrhagic toxin (TcsH) are regarded as the major virulence factors." ... the major virulence factors." "TcsL inactivates low molecular weight GTP-binding proteins of the Rho/Ras subfamilies by monoglucosylation. In cultured cell lines, ...
2009 NOV 9 ... study from the United States, "Protective antigen (PA), the binding subunit of anthrax toxin, is the major component in the current anthrax vaccine, but the fine antigenic structure ...
2009 NOV 2 ... publish new data in the report 'Binding and internalization of Clostridium botulinum C2 toxin.' "Clostridium botulinum C2 toxin is a binary toxin composed of an enzymatic component ...
2009 NOV 27 ... a molecular mass of 515 kDa. We examined whether these modi. cations interfere with the toxin-BtR175 interaction as a result of steric hindrance. 5-Iodoacetamidofluorescein modi. ... According to recent research from Koganei, Japan, "The determination of the receptor-binding region of Cry toxins produced by Bacillus thuringiensis is expected to facilitate an ...
2009 NOV 23 ... stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.' According to a study from Falmer, the United Kingdom, "Galectin-1, ... Falmer, the United Kingdom, "Galectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented ...
2009 OCT 19 ... between two peptides containing this scaffold, drosomycin and a truncated scorpion beta-toxin, has prompted us to examine and compare their biological effects." ... Drosophila melanogaster immune response. A truncated scorpion beta-toxin is capable of binding and inducing conformational alteration of voltage-gated sodium channels. Here, we show ...
2009 NOV 23 ... the only known substrate of the proteolytic A subunit (SubA) of a novel bacterial AB(5) toxin." "Here, we report that an engineered fusion protein, epidermal growth ... that manages ER stress. Glucose-regulated protein 78/immunoglobulin heavy-chain binding protein (GRP78/BiP) is an ER-resident protein that plays a central role in the ER stress ...
2009 OCT 20 ... Current study results from the report, 'Enhancement of toxin- and virus-neutralizing capacity of single-domain antibody fragments by ... their toxin-and virus-neutralizing capacity." "We isolated 27 VHHs binding Escherichia coli heat-labile toxin and expressed these in Saccharomyces cerevisiae. The ...
2009 NOV 9 ... and Immunity, "Three chimpanzee Fabs reactive with lethal factor (LF) of anthrax toxin were isolated and converted into complete monoclonal antibodies (MAbs) with human gamma ... with a 0.5 submolar ratio relative to LT. LF11H, on the other hand, had a slightly lower binding affinity to LF ( dissociation constant of 7.4 nM) and poor neutralization of LT in vitro ...
2009 NOV 2 ... "The anthrax protective antigen (PA) is the receptor-binding subunit common to lethal toxin (LT) and edema toxin (ET), which are responsible for the high mortality rates associated ...
2009 NOV 24 ... A report, 'The brain uncoupling protein UCP4 attenuates mitochondrial toxin-induced cell death: role of extracellular signal-regulated kinases in bioenergetics ... bioenergetics adaptation but also reduced the activation of cAMP-responsive element-binding (CREB) protein suggesting that CREB protein signaling contributes in part to ...
2009 NOV 1 ... and colleagues published their study in Biological & Pharmaceutical Bulletin (Shiga Toxin Kills Epithelial Cells Isolated from Distal but not Proximal Part of Mouse Colon. ... colonizing the human and cattle intestines. We previously demonstrated that recombinant binding subunits (Stx1B) bound to the mucosal epithelium of the distal but not that of the ...
