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2009 NOV 9 ... with the inactivation of STAT3. Expression of both CTTN and p-STAT3 was reduced in tumor cells following incubation with the JAK-specific inhibitor, AG490. Chromatin ... Investigators publish new data in the report 'Calreticulin promotes cellmotility and enhances resistance to anoikis through STAT3-CTTN-Akt pathway in esophageal ...
2009 NOV 9 ... Research, Kinase, Oncology, Protein Expression, Protein Kinase C, Proteins, Proteomics, Tumor Vascularization, Manchester Metropolitan University. This article was ... single knock-down inhibited low molecular weight hyaluronan (o-HA)-induced endothelial cell tube formation in Matrigel, but no change in the control, epidermal growth ... to knockdown the hyaluronan (HA) receptors CD44 and the receptor for hyaluronan-mediated motility (RHAMM) in vascular endothelial cells to investigate their role in angiogenesis. We ...
2009 NOV 9 ... by disulfide bonds, making it an excellent model to study overactivation of HER2 during tumor progression and metastasis." "Here we show that expression of 611-CTF ... and metastasis." "Here we show that expression of 611-CTF increases cellmotility in a variety of assays. Since cellmotility is frequently regulated by ...
2009 NOV 9 ... element-binding protein (CREB). However, the mechanism by which CREB contributes to tumor progression and metastasis remains unclear." "Here, we demonstrate that ... we demonstrate that stably silencing CREB expression in two human metastatic melanoma cell lines, A375SM and C8161-c9, suppresses tumor growth and experimental metastasis. ... of matrix metalloproteinase-2. Furthermore, its overexpression decreased melanoma cell motility and invasion through Matrigel, which was abrogated by silencing CCN1/CYR61 in low ...
2009 NOV 23 ... kinase belonging to the MEKK/STE11 subgroup of the MAPKKK family and plays a key role in tumor metastasis. However, it remains unclear about its functions in pancreatic cancer." ... siRNA. We observed that the activity of MMP2 was decreased in the MEKK1 depletion cell line (P < 0.05), accompanied with decreased phosphorylated ERK1/2. Our results ... and determined its role in BxPC3 cells via RNAi experiment. The abilities of invasion, motility, and adhesion of BxPC3 cells were detected by transwell assay, wound healing assay and ...
2009 NOV 2 ... with distant metastasis (p=0.002), lymph node involvement (p=0.032), and advanced tumor stage (p <0.001). Moreover, patients with PIK3CA copy number gain have a significant ... 3-kinases) are lipid kinases that regulate signalling pathways involved in cell proliferation, motility, and adhesion. Somatic mutations and amplification of the PIK3CA ...
2009 OCT 27 ... represents two distinct functions of p27, both necessary for it to fully act as a tumor suppressor," wrote S. Berton and colleagues. The researchers concluded: ... worse prognosis, suggesting that p27 levels could represent an important determinant in cell transformation and cancer development. Using a mouse model system based on v-src-induced ... from an elongated to a rounded cell shape, accompanied by amoeboid-like morphology and motility. Importantly, the acquisition of the amoeboid motility is associated with a greater ...
2009 NOV 23 ... in metastatic tumors and is involved in filopodia formation as well as promotion of tumor metastasis. Thus, Ezrin may serve as a potential target for anti-metastatic therapy." ... that berberine reduces filopodia formation of a nasopharyngeal carcinoma (NPC) cell line, 5-8F, at non-cytotoxic concentrations. Furthermore, invasion and motility of 5-8F ...
2009 NOV 16 ... "The identification of lung tumor-initiating cells and associated markers may be useful for optimization of therapeutic ... antigen-positive (CD133(+) ESA(+)) population is increased in primary nonsmall cell lung cancer (NSCLC) compared with normal lung tissue and has higher tumorigenic ... potential in SCID mice and expression of genes involved in stemness, adhesion, motility, and drug efflux than the CD133-counterpart. Cisplatin treatment of lung cancer cells in ...
2009 NOV 16 ... "Glioblastoma multiforme (GBM) is the most common and most malignant adult brain tumor. A characteristic of GBM is their highly invasive nature, making complete surgical ... myristoylated alanine-rich protein kinase C substrate (MARCKS), previously implicated in cell adhesion and motility, contributes to EGFR-mediated invasion of human GBM cells. ...
2009 NOV 9 ... in 76.4% of pancreatic carcinoma tissues and its expression level was associated with tumor size and lymphatic infiltration. Down-regulated LIV-1 cells showed significant ... by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in 9 cultured cell lines (8 carcinoma and I normal duct cell lines) and 24 pancreatic tissues (12 carcinoma ... significant inhibition of anchorage-dependent or -independent proliferation and cell motility in vitro and reduction of tumor growth and metastasis in vivo. Furthermore, nuclear ...
2009 NOV 16 ... correlated with poor patient survival. In vitro, FBP-1 predominantly induced tumorcell proliferation, while FBP-2 primarily supported migration in different HCC cell ... novel and frequent pro-tumorigenic mechanism promoting proliferation (tumor growth) and motility (dissemination) of human liver cancer cells. FBPs promote tumor-relevant functions by at ...
2009 NOV 16 ... study in Cancer Research (Melanoma Proteoglycan Modifies Gene Expression to Stimulate Tumor Cell Motility, Growth, and Epithelial-to-Mesenchymal Transition. Cancer Research, ...
2009 NOV 2 ... fusion proteins; however, its loss led to compromised homing and invasiveness of the tumor cells. Mef2c-dependent targets included several genes encoding matrix metalloproteinases ... Interferon, Mutagenesis, Myelomonocytic Leukemia, Myeloproliferation, Oncology, Stem Cell Research. This article was prepared by Hematology Week editors from staff ... chemokine ligands and receptors, providing a mechanistic link to increased homing and motility," wrote M. Schwieger and colleagues. The researchers concluded: "Thus, ...
2009 NOV 30 ... little or no pigment and high levels of Brn2::GFP expression are motile in the primary tumor and enter the vasculature. Significantly, the less differentiated state of motile and ... pigmented cells. Furthermore, TGF beta signaling induced hypopigmentation and increased cellmotility. Thus, a subset of less differentiated cells exits the primary tumor but ...
2009 NOV 2 ... from patients treated with radiotherapy. In contrast, ZEB1 was rarely expressed in tumor tissues; and E-cadherin status did not correlate with the patients' survival. SIP1 ... studied. Here, we performed a comparative study of SIP1 and ZEB1 proteins in cancer cell lines and in one form of human malignancy, carcinoma of the bladder. Whereas ZEB1 ... in all E-cadherin-negative carcinoma cell lines, being in part responsible for the high motility of bladder cancer cells, SIP1 was hardly ever detectable in carcinoma cells in culture. ...
2009 NOV 23 ... "Mouse models have markedly improved our understanding of cancer development and tumor biology. However, these models have shown limited efficacy as tractable systems for ... These experiments have identified a central role for regulators of actin dynamics and cellmotility in lymphoma cell homeostasis in vivo. Validation experiments confirmed that ...
2009 NOV 16 ... Fresh data on cholangio cancer are presented in the report 'Fascin is involved in tumor necrosis factor-alpha-dependent production of MMP9 in cholangiocarcinoma.' "Fascin is ... of MMP9 in cholangiocarcinoma.' "Fascin is an actin-binding protein involved in the cellmotility. Recently, aberrant expression of fascin in carcinoma cells was reported to ...
2009 NOV 2 ... subcutaneously into the dorsal region of SCID mice (five mice in each group). After a tumor was visualized, animals were assigned to either the ALB6 treatment group or the control ... and has been shown to be involved in a variety of cellular activities such as motility, cell signaling, proliferation, adhesion, and metastasis. However, very little is known about ...
2009 NOV 16 ... remains low at 10% to 40% due to late diagnosis, metastasis, and resistance of the tumor to radiotherapy and chemotherapy," scientists writing in the journal Molecular Cancer ... Cancer Therapeutics report. "NF-kappa B is involved in the regulation of cell growth, survival, and motility, but little is known about the role of this signaling ...
